Search results for "Sequence"

Receptor-mediated uptake of boron-rich neuropeptide y analogues for boron neutron capture therapy.

2014

Peptidic ligands selectively targeting distinct G protein-coupled receptors that are highly expressed in tumor tissue represent a promising approach in drug delivery. Receptor-preferring analogues of neuropeptide Y (NPY) bind and activate the human Y1 receptor subtype (hY1 receptor), which is found in 90% of breast cancer tissue and in all breast-cancer-derived metastases. Herein, novel highly boron-loaded Y1 -receptor-preferring peptide analogues are described as smart shuttle systems for carbaboranes as (10) B-containing moieties. Various positions in the peptide were screened for their susceptibility to carbaborane modification, and the most promising positions were chosen to create a mu…

Brown Dwarfs in ChaI Dark Cloud

2004

We present the results of a multiband survey for brown dwarfs in the Chamaeleon I dark cloud with the Wide Field Imager (WFI) camera at the ESO/MPG 2.2-m telescope on La Silla (Chile) on 28-May to 03-Jun 1999. The survey has revealed a substantial population of brown dwarfs in this southern star-forming region. Candidates were selected from R, I and H{alpha} imaging observations. We also observed in two medium-band filters, M855 and M915, for spectral type determination. The former filter covers a wavelength range containing spectral features characteristic of M-dwarfs, while the latter lies in a relatively featureless wavelength region for these late-type objects. A correlation was found b…

VCNS II. The IR-excess-selected population

2015

We performed a deep wide-field (6.76 square-degrees) near-infrared survey with the VISTA telescope that covers the entire extent of the Carina nebula complex. Complementing the VISTA near-infrared catalog with Spitzer IRAC mid-infrared photometry improves the situation of the background contamination considerably. We find that a (J-H) versus (Ks-[4.5]) color-color diagram is well suited to tracing the population of YSO-candidates (cYSOs) by their infrared excess. We identify 8781 sources with strong infrared excess, which we consider as cYSOs. This sample is used to investigate the spatial distribution of the cYSOs with a nearest-neighbor analysis. The surface density distribution of cYSOs …

Evolutionary Study of Disorder in Protein Sequences

2020

Intrinsically disordered proteins (IDPs) contain regions lacking intrinsic globular structure (intrinsically disordered regions, IDRs). IDPs are present across the tree of life, with great variability of IDR type and frequency even between closely related taxa. To investigate the function of IDRs, we evaluated and compared the distribution of disorder content in 10,695 reference proteomes, confirming its high variability and finding certain correlation along the Euteleostomi (bony vertebrates) lineage to number of cell types. We used the comparison of orthologs to study the function of disorder related to increase in cell types, observing that multiple interacting subunits of protein comple…

A New Feature Selection Methodology for K-mers Representation of DNA Sequences

2015

DNA sequence decomposition into k-mers and their frequency counting, defines a mapping of a sequence into a numerical space by a numerical feature vector of fixed length. This simple process allows to compare sequences in an alignment free way, using common similarities and distance functions on the numerical codomain of the mapping. The most common used decomposition uses all the substrings of a fixed length k making the codomain of exponential dimension. This obviously can affect the time complexity of the similarity computation, and in general of the machine learning algorithm used for the purpose of sequence analysis. Moreover, the presence of possible noisy features can also affect the…

Sustainable Working Life Patterns in a Swedish Twin Cohort : Age-Related Sequences of Sickness Absence, Disability Pension, Unemployment, and Prematu…

2022

We aimed to investigate sustainable working life via age-related sequences of sickness absence (SA), disability pension (DP), unemployment (UE), premature death, and the influence of individual characteristics, accounting for familial confounding. The sample included monozygotic (MZ) and dizygotic (DZ) same-sexed twin pairs with register data (n = 47,450) that were followed for 10 years in four age cohorts: 26–35 (n = 9892), 36–45 (n = 10,620), 46–55 (n = 12,964) and 56–65 (n = 13,974). A sequence analysis was done in a 7-element state space: 1. “Sustainable working life”: SA/DP 0–30 days and UE 0–90 days; 2. “Unemployment >90 days”: SA/DP 0–30 days and UE > 90 days; 3. “Moderate SA/DP”: SA…

Molecular Cytogenetic Characterization of the Sicilian Endemic Pond Turtle Emys trinacris and the Yellow-Bellied Slider Trachemys scripta scripta (Te…

2020

Turtles, a speciose group consisting of more than 300 species, demonstrate karyotypes with diploid chromosome numbers ranging from 2n = 26 to 2n = 68. However, cytogenetic analyses have been conducted only to 1/3rd of the turtle species, often limited to conventional staining methods. In order to expand our knowledge of the karyotype evolution in turtles, we examined the topology of the (TTAGGG)n telomeric repeats and the rDNA loci by fluorescence in situ hybridization (FISH) on the karyotypes of two emydids: the Sicilian pond turtle, Emys trinacris, and the yellow-bellied slider, Trachemys scripta scripta (family Emydidae). Furthermore, AT-rich and GC-rich chromosome regions were detected …

Konsekwencje przyjęcia chrześcijaństwa dla państwa Mieszka I : głos w jubileuszowej dyskusji

2016

Przeżywany w Polsce jubileusz 1050-lecia chrztu Polski stanowi okazję do naukowej refleksji nad znaczeniem tegoż wydarzenia w historii naszego narodu. Co tak istotnego wydarzyło się, że akt chrztu władcy Polan – księcia Mieszka w 966 r. stał się tak ważny, że określany jest również początkiem istnienia państwa polskiego, kiedy to Polska wyszła z dziejowej prehistorii, a zaczęła istnieć historycznie? Autor snuje historiozoficzną interpretację skutków chrztu Mieszka, o których wydaje się, że sam władca wprost nie myślał i raczej ich nie zakładał. Dla władcy, który przeżywszy osobiste nawrócenie chciał przekazać światło wiary swoim poddanym, liczył się głównie element duchowy, nadprzyrodzony. …

Statistical analysis of life sequence data

2016

Clinical significance of the polymerase chain reaction (PCR) assay in chronic HBV carriers

1992

PCR was evaluated as a clinical tool for use in accurate identification of the specific etiologic agent in chronic HBV carriers. The method was found to be valuable in diagnosis and for monitoring therapy, as well as for elucidation of genotypic variants of HBV in chronic HBV cases. By this means an HBV defective variant with alterations in the preSl/preS2 sequence was detected and is consequently described here.