Search results for "Sial"

Pränatale Diagnostik der Sialidose, eines Defektes des lysosomalen Enzyms Neuraminidase

1988

Die Sialidose, eine lysosomale Speicherkrankheit aus der Gruppe der Oligosaccharidosen, ist ein genetischer Enzymdefekt mit stark eingeschrankter Lebenserwartung des betroffenen Kindes. Nach vorheriger Geburt eines an dieser Erkrankung verstorbenen Kindes gelang mit Hilfe der biochemischen Analyse von Amnionzellen der korrekte pranatale Ausschlus einer Sialidose unter Voraussage eines heterozygoten Ubertragerstatus. Aus nicht geklarter Ursache war das Wachstum sowohl der Amnionzellen als auch der postnatal untersuchten Fibroblasten deutlich vermindert. Diese Beobachtung sollte bei weiteren pranatalen Untersuchungen uberpruft werden. Die Moglichkeit der pranatalen Diagnostik einer Sialidose …

Lymphoid lesions of salivary glands : malignant and Benign

2007

Lesions of salivary glands with a prominent lymphoid component are a heterogeneous group of diseases that include benign reactive lesions and malignant neoplasms. Occasionally, these pathologic entities present difficulties in the clinical and pathological diagnosis and prognosis. Lymphoepithelial sialadenitis, HIV-associated salivary gland disease, chronic sclerosing sialadenitis, Warthin tumor, and extranodal marginal zone B-cell lymphoma are examples of this pathology that are sometimes problematic to differentiate from one another. In this paper the author reviewed the main clinical, pathological and prognostic features of these lesions.

A Russian Radical Conservative Challenge to the Liberal Global Order : Aleksandr Dugin

2019

The chapter examines Russian political theorist Aleksandr Dugin’s (b. 1962) challenge to the Western liberal order. Even though Dugin’s project is in many ways a theoretical epitome of Russia’s contemporary attempt to profile itself as a regional great power with a political and cultural identity distinct from the liberal West, Dugin can also be read in a wider context as one of the currently most prominent representatives of the culturally and intellectually oriented international New Right. The chapter introduces Dugin’s role on the Russian right-wing political scene and his international networks, Russian neo-Eurasianism as his ideological footing, and his more recent “fourth political t…

The asialoglycoprotein receptor mediates hepatic binding and uptake of natural hepatitis B virus particles derived from viraemic carriers.

1994

As a putative mechanism of hepatitis B virus (HBV) uptake into hepatocytes the interaction between HBV and the hepatic, human-derived asialoglycoprotein receptor (ASGPR) was investigated. Sera from patients with different variations of hepatitis B surface antigen-(HBsAg) positive chronic hepatitis, HBV particles isolated from HBV carriers with high-titre viraemia and commercial HBsAg served as sources of HBV. ASGPR was affinity-purified from human liver. HBV that had bound to isolated ASGPR was either detected by radio-immunoassay using solid-phase bound ASGPR or enzyme immunoassay with biotin-ASGPR bound to immobilized HBV. Furthermore, binding and uptake of purified, 125I-labelled HBV par…

The asialoglycoprotein receptor as target structure in autoimmune liver diseases.

1991

Immunohistochemical localization of polysialic acid in tissue sections: differential binding to polynucleotides and DNA of a murine IgG and a human I…

1990

For immunolocalization of alpha(2-8)-linked polysialic acid, which forms part of the neural cell adhesion molecule (N-CAM), two monoclonal antibodies, MAb735 and IgMNOV, were employed. Both antibodies have previously been shown to bind the extremely low immunogenic capsular polysaccharide of group B meningococci, which also consists of alpha(2-8) polysialic acid, but not to other, even closely related forms of polysialic acid. Despite the identical polysaccharide specificity of these two MAb, we observed marked differences of the staining pattern in tissue sections. We showed that these differences in immunostaining were due to the crossreactivity of IgMNOV with polynucleotides and DNA. MA…

Emosjonelt arbeid blant frontlinjeansatte : Hvordan opplever og håndterer nav-ansatte det emosjonelle arbeidet de utøver på jobb?

2017

Masteroppgave Sosiologi og sosialt arbeid ME522 - Universitetet i Agder 2017 Formålet med denne oppgaven er å få en forståelse for det emosjonelle arbeidet som frontlinjeansatte på nav utøver. Fokuset er å belyse både hvordan de opplever og hvordan de håndterer ulike situasjoner de kommer opp i. Oppgaven er basert på intervjuer og observasjoner av totalt 13 ansatte på et lokalt nav-kontor som arbeider tett med brukere innenfor ulike avdelinger. Med utgangspunkt i datamaterialet, analyseres innholdet først før det blir drøftet opp mot teori. Teoriene til Erving Goffman og Arlie Hochschild blir brukt bevisst gjennom hele oppgaven for å få frem ulike momenter ved emosjonsarbeidet og selve møte…

Demokraattisen kokeilullisuuden puolesta, kapitalismia vastaan

2019

Kirja-arvostelu teoksesta Axel Honneth, Sosialismin idea (Die Idee des Sozialismus, 2015). Suom. Arto Kuusterä & Jussi Palmusaari. Gaudeamus, Helsinki 2018. 224 s. nonPeerReviewed

Problemi di giurisdizione nel contrasto al traffico di migranti via mare

2018

I trafficanti di esseri umani si avvalgono con sempre più insistenza di ben collaudati protocolli operativi. Questi ultimi consentono loro di sottrarsi alla giurisdizione penale italiana che non si radica qualora – in ossequio ai criteri di cui all’art. 6 c.p.ed in conformità alla Convenzione sull’Alto Mare– l’azione illecita avvenga in acque internazionali.Così, premesse alcune linee concettuali sui limiti spaziali alla efficacia della legge penale, l’indagine si sofferma sulla soluzione ermeneutica offerta dallaCassazione che, apparentemente in modo sbrigativo e per esigenze di effettività della risposta punitiva, ha fatto ricorso alla controversa figura dell’autore mediato per sanzionare condott…

Reduction of clozapine-induced hypersalivation by pirenzepine is safe.

2004

Introduction Hypersalivation is known as a frequent, disturbing, and socially stigmatizing side effect of therapy with the atypical antipsychotic clozapine. It has been shown that the addition of the anticholinergic pirenzepine is able to reduce clozapine-induced hypersalivation, probably by blocking M4-receptors. Nevertheless, a pharmacokinetic interaction between both compounds cannot be excluded. Methods In this pilot study, 29 schizophrenic patients (ICD-10; 51.7 % female; age: 36.7 +/- 8.7 years [mean +/- SD]) were included. Serum concentrations of clozapine and its pharmacologically active metabolite N-desmethylclozapine were determined under steady-state conditions by automated HPLC …