Search results for "Sial"
showing 10 items of 626 documents
Brain Control of Plasma Cholesterol Involves Polysialic Acid Molecules in the Hypothalamus
2017
IF 3.566; International audience; The polysialic acid (PSA) is a large glycan that is added to cell-surface proteins during their post-translational maturation. In the brain, PSA modulates distances between cells and controls the plasticity of the nervous system. In the hypothalamus, PSA is involved in many aspects of energy balance including food intake, osmoregulation, circadian rhythm, and sleep. In this work, we investigated the role of hypothalamic PSA in the regulation of plasma cholesterol levels and distribution. We report that HFD consumption in mice rapidly increased plasma cholesterol, including VLDL, LDL, and HDL-cholesterol. Although plasma VLDL-cholesterol was normalized withi…
Effects of PSA Removal from NCAM on the Critical Period Plasticity Triggered by the Antidepressant Fluoxetine in the Visual Cortex.
2016
Neuronal plasticity peaks during critical periods of postnatal development and is reduced towards adulthood. Recent data suggests that windows of juvenile-like plasticity can be triggered in the adult brain by antidepressant drugs such as Fluoxetine. Although the exact mechanisms of how Fluoxetine promotes such plasticity remains unknown, several studies indicate that inhibitory circuits play an important role. The polysialylated form of the neural cell adhesion molecules (PSA-NCAM) has been suggested to mediate the effects of Fluoxetine and it is expressed in the adult brain by mature interneurons. Moreover, the enzymatic removal of PSA by neuroaminidase-N not only affects the structure of…
Lack of Hypothalamus Polysialylation Inducibility Correlates With Maladaptive Eating Behaviors and Predisposition to Obesity
2018
This original research article (6 p.) is part of the research topic . Specialty section: This article was submitted to Neuroenergetics, Nutrition and Brain Health, a section of the journal Frontiers in Nutrition.; International audience; High variability exists in individual susceptibility to develop overweight in an obesogenic environment and the biological underpinnings of this heterogeneity are poorly understood. In this brief report, we show in mice that the vulnerability to diet-induced obesity is associated with low level of polysialic acid-neural cell adhesion molecule (PSA-NCAM), a factor of neural plasticity, in the hypothalamus. As we previously shown that reduction of hypothalami…
Synthesising the shifting terminology of community health: A critiquing review of agent-based approaches
2021
The field of community health promotion encompasses a wide range of approaches, including bottom-up approaches that recognise and build on the agency and strengths of communities to define and pursue their health goals. Momentum towards agent-based approaches to community health promotion has grown in recent years, and several related but distinct conceptual and methodological bodies of work have developed largely in isolation from each other. The lack of a cohesive collection of research, practice, and policy has made it difficult to learn from the innovations, best practices, and shortcomings of these approaches, which is exacerbated by the imprecise and inconsistent use of related terms.…
Socio-demographic, personal, environmental and behavioral correlates of different modes of transportation to work among Norwegian parents
2016
Abstract Background Cycling and brisk-walking to work represents an opportunity to incorporate sustainable transport related moderate- to- vigorous physical activity (MVPA) into daily routine among adults, and thus, may make an important contributing to health. Despite the fact that walking and cycling is an option for many commuters and also brings a number of benefits, a considerable proportion of commuters choose to use other means of transport when cycling and walking would be a highly appropriate transport mode. The object of this study was to assess the associations between modes of commuting to the workplace among parental adults; taking socio-demographic, personal, environmental and…
Guidelines for the Direct Detection ofAnaplasmaspp. in Diagnosis and Epidemiological Studies
2017
The genus Anaplasma (Rickettsiales: Anaplasmataceae) comprises obligate intracellular Gram-negative bacteria that are mainly transmitted by ticks, and currently includes six species: Anaplasma bovis, Anaplasma centrale, Anaplasma marginale, Anaplasma phagocytophilum, Anaplasma platys, and Anaplasma ovis. These have long been known as etiological agents of veterinary diseases that affect domestic and wild animals worldwide. A zoonotic role has been recognized for A. phagocytophilum, but other species can also be pathogenic for humans. Anaplasma infections are usually challenging to diagnose, clinically presenting with nonspecific symptoms that vary greatly depending on the agent involved, th…
The king who came down from the mountain : the image and the cult of personality of the "eternal president" Kim Il-Sung in official state propaganda …
2017
Tutkielma käsittelee Korean Demokraattisen Kansantasavallan (KDKT) ensimmäisen päämiehen ja johtajan Kim il-Sungin henkilökultin luomistyötä, sekä esikuvia, joita hän propagandakoneistonsa kanssa käytti henkilökulttinsa luomiseen. Tarkasteltu ajanjakso sijoittuu vuodesta 1945 noin vuoden 1962 loppuun. Alun perin Neuvostoliiton asevoimien tuella valtaan noussut nuori johtaja ryhtyi pian kehittämään itselleen omanlaistaan henkilökulttia, jonka esikuvina toimivat niin Neuvostoliiton Josef Stalin kuin myös kansallissosialistisen Saksan Adolf Hitler. Molemmat edellä mainitut diktaattorit toimivat Kim il-Sungille esimerkkinä monilla kulttuurin ja propagandan saroilla, niin esimerkiksi maalaustait…
Radikaalisti sukupuolesta : naisten asemaa tutkiva komitea politiikan uudistajana 1960-luvulla
2022
Sanna Marinin johtama hallitus on herättänyt keskustelua intersektionaalista feminismiä edustavalla poliittisella profiilillaan. Akateemisen keskustelun käyttö politiikan muutosvoimana ei kuitenkaan ole uutta, vaan näkyi jo 1960-luvulla muotoillussa tasa-arvopolitiikassa. nonPeerReviewed
Radical sex role ideology and the Finnish gender role movement in the late 1960s
2022
An active discussion of gender roles and the need to renegotiate them took place in the late 1960s in Finland. While previous studies have associated this ‘sex role debate’ with the independent civic organisation Association 9, this article focuses on the wider gender role movement. The article analyses the interplay and differences among the Finnish Women’s Democratic League, the Committee for Women’s Status, and Association 9’s grassroots activism between 1965 and 1970. It demonstrates that similar ideas about sex roles were presented simultaneously in two public spheres: the dominant public, where the ideas were promoted by Association 9, and the people’s democratic counterpublic, which …