6533b872fe1ef96bd12d3839
RESEARCH PRODUCT
Lack of Hypothalamus Polysialylation Inducibility Correlates With Maladaptive Eating Behaviors and Predisposition to Obesity
Selma Ben FradjAmélie LaderrièreVeronique DouardCaroline RigaultGaëlle BoudryDanae NuzzaciLuc PénicaudAlexandre BenaniEmmanuelle NédélecAleth LemoineFabienne LiénardXavier Brenachotsubject
0301 basic medicineobesityfood intakePSA-NCAMEndocrinology Diabetes and Metabolismmedia_common.quotation_subject[SDV]Life Sciences [q-bio][SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiologybrainmaladaptive eating behaviorlcsh:TX341-641BiologyOverweightEnergy homeostasis03 medical and health sciencesNeuroplasticitymedicineFood and Nutritionhypothalamusmedia_commonNutritionOriginal ResearchNutrition and Dieteticssynaptic plasticitycomportement alimentairepolysialylation[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/NeurobiologyNeurosciencesAppetitemedicine.diseaseprise alimentaireObesity3. Good health[SDV] Life Sciences [q-bio]food intake;obesity;maladaptive eating behavior;synaptic plasticity;PSA-NCAM;polysialylation;brain;hypothalamusEating disordersobésité030104 developmental biologynervous systemHypothalamusNeurons and CognitionSynaptic plasticityAlimentation et Nutritionplasticité synaptiquecerveaumedicine.symptomlcsh:Nutrition. Foods and food supplyNeuroscienceFood Sciencedescription
This original research article (6 p.) is part of the research topic . Specialty section: This article was submitted to Neuroenergetics, Nutrition and Brain Health, a section of the journal Frontiers in Nutrition.; International audience; High variability exists in individual susceptibility to develop overweight in an obesogenic environment and the biological underpinnings of this heterogeneity are poorly understood. In this brief report, we show in mice that the vulnerability to diet-induced obesity is associated with low level of polysialic acid-neural cell adhesion molecule (PSA-NCAM), a factor of neural plasticity, in the hypothalamus. As we previously shown that reduction of hypothalamic PSA-NCAM is sufficient to alter energy homeostasis and promote fat storage under hypercaloric pressure, inter-individual variability in hypothalamic PSA-NCAM might account for the vulnerability to diet-induced obesity. These data support the concept that reduced plasticity in brain circuits that control appetite, metabolism and body weight confers risk for eating disorders and obesity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-12-01 | Frontiers in Nutrition |