Search results for "Sideritis"

Kaurane diterpenoids from three Sideritis species

2005

Some kaurane diterpenoids were isolated from 3 species of the genus Sideritis (Lamiaceae) growing in the Eastern Mediterranean region. Sideritis libanotica subsp. libanotica contained siderol 2 and sideridiol 3. Sideritis erythrantha var. erythrantha yielded sideridiol 3. Sideritis perfoliata gave siderol 2, sideridiol 3 and sideritriol 4. The products are known as they occur in another species of Sideritis growing in Italy and in other species growing also in Turkey. The products are isolated for the first time from these 3 species. The taxonomic significance of these results is discussed.

Anti-HIV Agents Derived from the ent-Kaurane Diterpenoid Linearol

2002

Twenty-six semisynthetic ent-kaurane derivatives of linearol (1) have been investigated for their anti-HIV effects. Five compounds (4, 7, 11, 25, and 26) showed significant activity against HIV replication in H9 lymphocyte cells with EC(50) values in the range <0.1-3.11 microg/mL. With TI values of 163 and 184, compounds 4 and 25 are especially promising for further development as potential anti-HIV agents.

Anti-inflammatory compounds from Sideritis javalambrensis n-hexane extract.

1989

The anti-inflammatory activities of the n-hexane extract of Sideritis javalambrensis and several purified fractions were investigated using the carrageenan mouse paw edema test. Progressive fractionation led to the isolation of the active principles ent-16-hydroxy-13-epimanoyl oxide [1] and esters of tyrosol with palmitic, stearic, behenic, and lignoceric acids.

Antibacterial and antioxidant activities in Sideritis italica (Miller) Greuter et Burdet essential oils

2006

Sideritis italica (Miller) Greuter et Burdet is a widespread Lamiacea in the Mediterranean region used in traditional medicine. Essential oils were antibacterial against nine ATCC and as many clinically isolated Gram-positive and Gram-negative bacterial strains. Antibacterial activity was also found against Helicobacter pylori: a dose-dependant inhibition was shown between 5 and 25 microg/ml. The antibacterial activity of the oils was expressed as MICs (minimum inhibitory concentrations) and MBCs (minimum bactericidal concentrations). At a concentration between 3.9 and 250 microg/ml the oils showed a significant antibacterial effect against both Gram-negative and Gram-positive bacteria. In …

Flavone Glycosides of Sideritis incana

1986

Eubotriol and eubol, new diterpenes fromSideritis euboea

1977

2 new diterpenes Eubotriol (ent-kaur-16-ene-7α, 15β, 18triol) (I), and eubol (ent-kaur-16-ene-7α-acetoxy-15β, 18 diol) (II) have been isolated from Sideritis euboea Helder.

Essential Oil from Sideritis funkiana

1986

Anti-Inflammatory Activity of a Flavone from Sideritis leucantha.

1986

Studies on the gastric anti-ulcer activity of hypolaetin-8-glucoside

1988

The gastric anti-ulcer activity of hypolaetin-8-O-β-D-glucoside (H-8-G), a flavonoid isolated from Sideritis leucantha, has been studied in rats. This compound significantly reduced gastric lesions induced by ethanol or acetylsalicylic acid (ASA), with an increase in mucus production. In the pylorus-ligated rat, H-8-G did not affect the volume of gastric secretion but decreased its acidity and peptic activity. The anti-ulcer activity of this flavonoid does not depend on stimulation of cell proliferation in the rat gastric mucosa. Our results suggest that H-8-G activity is related to its cytoprotective effects [mediated by endogenous prostaglandins (PGs) and associated to an increase in gast…

Seasonal variation of hypolaetin 8-glucoside inSideritis mugronensis borja

1990

A quantitative analysis of the antiinflammatory flavonoid hypolaetin 8-glucoside from Sideritis mugronensis during an annual growth cycle was carried out. After an irregular increase in spring, the maximum levels were reached and maintained in early summer samples.