Search results for "Sigma"
showing 10 items of 346 documents
"Table 3" of "Measurement of the nuclear modification factor for inclusive jets in Pb+Pb collisions at $\sqrt{s_\mathrm{NN}}=5.02$ TeV with the ATLAS…
2018
No description provided.
Search for a common baryon source in high-multiplicity pp collisions at the LHC
2020
Physics letters / B B811, 135849 (2020). doi:10.1016/j.physletb.2020.135849
Scattering Studies with Low-Energy Kaon-Proton Femtoscopy in Proton-Proton Collisions at the LHC
2020
The study of the strength and behaviour of the antikaon-nucleon ($\mathrm{\overline{K}N}$) interaction constitutes one of the key focuses of the strangeness sector in low-energy Quantum Chromodynamics (QCD). In this letter a unique high-precision measurement of the strong interaction between kaons and protons, close and above the kinematic threshold, is presented. The femtoscopic measurements of the correlation function at low pair-frame relative momentum of (K$^+$ p $\oplus$ K$^-$ $\overline{\mathrm{p}}$) and (K$^-$ p $\oplus$ K$^+$ $\overline{\mathrm{p}}$) pairs measured in pp collisions at $\sqrt{s}$ = 5, 7 and 13 TeV are reported. A structure observed around a relative momentum of 58 Me…
Antidepressive-like Behavior-Related Metabolomic Signatures of Sigma-1 Receptor Knockout Mice
2022
Sigma-1 receptor (Sig1R) has been proposed as a therapeutic target for neurological, neu-rodegenerative, and psychiatric disorders, including depression and anxiety. Identifying metabolites that are affected by Sig1R absence and cross-referencing them with specific mood-related behaviors would be helpful for the development of new therapies for Sig1R-associated disorders. Here, we examined metabolic profiles in the blood and brains of male CD-1 background Sig1R knockout (KO) mice in adulthood and old age and correlated them with the assessment of depression-and anxiety-related behaviors. The most pronounced changes in the metabolic profile were observed in the plasma of adult Sig1R KO mice.…
Antipsychotic effects and tolerability of the sigma ligand EMD 57445 (panamesine) and its metabolites in acute schizophrenia: an open clinical trial.
2000
Antipsychotic efficacy and side effects of the selective sigma ligand EMD 57445 (panamesine) were investigated in 12 patients (6 males, 6 females) who met DSM-III-R criteria for schizophrenia. A 4-week open clinical study revealed only modest effects of EMD 57445 and its metabolites on positive and negative symptoms of schizophrenia. Extrapyramidal and other side effects were moderate, although a significant increase in mild dyskinetic movements was found. Five patients, four of whom were females, completed the trial. Dropouts were mainly due to treatment failure. Antipsychotic effects were significantly greater in female than male patients.
Occupancy of striatal D 2 -like dopamine receptors after treatment with the sigma ligand EMD 57445, a putative atypical antipsychotic
1999
Rationale: EMD 57445 (panamesine) is a high affinity sigma ligand with the profile of an atypical antipsychotic in animal studies. It has been reported recently to have antipsychotic activity in schizophrenia. However, its metabolite, EMD 59983, binds also to D2 and D3 dopamine (DA) receptors. Objectives: The aim of this study was to test, using single photon emission computed tomography (SPECT) and [123I]iodobenzamide (IBZM) as the radiotracer, whether EMD 59983 would pass the blood-brain barrier and to what extent it would contribute to the effects of EMD 57445 in schizophrenia. Methods: Two IBZM SPECT-scans were performed in five neuroleptic-free schizophrenic patients (DSM IV), one befo…
Ādas mezenhimālo cilmes šūnu fenotipa raksturojums pēc neirotrofo faktoru inducētas neirodiferenciācijas
2015
Ādas mezenhimālās cilmes šūnas (Ā-MCš), pakļautas specifiskiem faktoriem, spēj diferencēties par neironiem un glijas šūnām. Maģistra darba mērķis bija analizēt Ā-MCš fenotipu pēc neirotrofo faktoru inducētas neirodiferenciācijas. Neiroektodermas gēnu ekspresiju Ā-MCš analizēja ar qPCR, cilmes šūnu pluripotences un mezenhimālo marķieru ekspresiju ar plūsmas citometriju, Sigma-1 receptora ekspresiju (SigmaR1) ar qPCR un IF, kā arī BDNF sekrēciju ar ELISA. Ā-MCš fenotipu salīdzināja ar ReNcell CX šūnām. Retīnskābes indukcijas barotnē novēroja nervu kores gēnu ekspresijas pieaugumu. Cilmes šūnu marķieru ekspresija pēc diferenciācijas kritās. Mezenhimālo marķieru ekspresija samazinājās vienā no …
Chiral coupled channel dynamics of theΛ(1520)and theK−p→π0π0Λreaction
2005
We study the $\ensuremath{\Lambda}(1520){D}_{03}$ in a chiral coupled channel approach. This resonance appears to be dynamically generated from the interaction of the decuplet of baryons and the octet of mesons in s wave, and its treatment is improved here with the phenomenological inclusion of the $\overline{K}N$ and $\ensuremath{\pi}\ensuremath{\Sigma}$ channels in d wave. Since the most important building block in $\ensuremath{\Lambda}(1520)$ is the $\ensuremath{\pi}{\ensuremath{\Sigma}}^{*}(1385){P}_{13}$ channel, we study the ${K}^{\ensuremath{-}}p\ensuremath{\rightarrow}\ensuremath{\pi}{\ensuremath{\Sigma}}^{*}(1385)({\ensuremath{\pi}}^{0}\ensuremath{\Lambda})$ reaction in the region …
Measurements of baryon pair decays of chi(cJ) mesons
2013
Using 106 $\times 10^{6}$ $\psi^{\prime}$ decays collected with the BESIII detector at the BEPCII, three decays of $\chi_{cJ}$ ($J=0,1,2$) with baryon pairs ($\llb$, $\ssb$, $\SSB$) in the final state have been studied. The branching fractions are measured to be $\cal{B}$$(\chi_{c0,1,2}\rightarrow\Lambda\bar\Lambda) =(33.3 \pm 2.0 \pm 2.6)\times 10^{-5}$, $(12.2 \pm 1.1 \pm 1.1)\times 10^{-5}$, $(20.8 \pm 1.6 \pm 2.3)\times 10^{-5}$; $\cal{B}$$(\chi_{c0,1,2}\rightarrow\Sigma^{0}\bar\Sigma^{0})$ = $(47.8 \pm 3.4 \pm 3.9)\times 10^{-5}$, $(3.8 \pm 1.0 \pm 0.5)\times 10^{-5}$, $(4.0 \pm 1.1 \pm 0.5) \times 10^{-5}$; and $\cal{B}$$(\chi_{c0,1,2}\rightarrow\Sigma^{+}\bar\Sigma^{-})$ = $(45.4 \pm…
Λ(1520)andΣ(1385)in the nuclear medium
2006
Recent studies of the {lambda}(1520) resonance within chiral unitary theory with coupled channels find the resonance as a dynamically generated state from the interaction of the decuplet of baryons and the octet of mesons, essentially a quasibound state of {pi}{sigma}{sup *}(1385) in this case, although the coupling of the {lambda}(1520) to the KN and {pi}{sigma} makes this picture only approximate. The {pi}{sigma}{sup *}(1385) decay channel of the {lambda}(1520) is forbidden in free space for the nominal mass of the {sigma}{sup *}(1385), but the coupling of the {pi} to ph components in the nuclear medium opens new decay channels of the {lambda}(1520) in the nucleus and produces a much larg…