Search results for "Signal"

Self-Organizing Architectures for Digital Signal Processing

2013

A New SOM Initialization Algorithm for Nonvectorial Data

2008

Self Organizing Maps (SOMs) are widely used mapping and clustering algorithms family. It is also well known that the performances of the maps in terms of quality of result and learning speed are strongly dependent from the neuron weights initialization. This drawback is common to all the SOM algorithms, and critical for a new SOM algorithm, the Median SOM (M-SOM), developed in order to map datasets characterized by a dissimilarity matrix. In this paper an initialization technique of M-SOM is proposed and compared to the initialization techniques proposed in the original paper. The results show that the proposed initialization technique assures faster learning and better performance in terms…

Measurement of the forward-backward asymmetry of e(+)e(-)-]z-]b(b)over-bar using prompt leptons and a lifetime tag

1995

The forward-backward asymmetry of the process e+e-→Z→b {Mathematical expression} has been measured using events collected by the DELPHI experiment during the 1991 and 1992 LEP runs. This data sample corresponded to 884 000 hadronic Z decays at a centre-of-mass energy {Mathematical expression}. The tagging of b-quark events was performed using two approaches; the first was based on the semileptonic decay channels b→X+μ and b→X+e, the second used a lifetime tag with jet-charge reconstruction. The results of these two methods were combined to give {Mathematical expression} With the semileptonic sample, the forward-backward asymmetry of the process e+e-→Z→ {Mathematical expression} was also mea…

Improved Upper Limit on the Neutrino Mass from a Direct Kinematic Method by KATRIN

2019

We report on the neutrino mass measurement result from the first four-week science run of the Karlsruhe Tritium Neutrino experiment KATRIN in spring 2019. Beta-decay electrons from a high-purity gaseous molecular tritium source are energy analyzed by a high-resolution MAC-E filter. A fit of the integrated electron spectrum over a narrow interval around the kinematic end point at 18.57 keV gives an effective neutrino mass square value of (−1.0−1.1+0.9) eV2. From this, we derive an upper limit of 1.1 eV (90% confidence level) on the absolute mass scale of neutrinos. This value coincides with the KATRIN sensitivity. It improves upon previous mass limits from kinematic measurements by almost a …

Attenuation of NF-κB Signaling Response to UVB Light during Cellular Senescence

1999

The ability of cells to adapt to environmental stresses undergoes a progressive reduction during aging. NF-kappaB-mediated signaling is a major defensive system against various environmental challenges. The aim of this study was to find out whether replicative senescence affects the response of the NF-kappaB signaling pathway to UVB light in human WI-38 and IMR-90 fibroblasts. The exposure of early passage fibroblasts to UVB light inhibited the proliferation and induced a flat phenotype similar to that observed in replicatively senescent fibroblasts not exposed to UVB light. The UVB radiation dose used (153 mJ/cm2) did not induce apoptosis in either early or late passage WI-38 fibroblasts. …

Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulatin…

2014

Senescence is a prominent solid tumor response to therapy in which cells avoid apoptosis and instead enter into prolonged cell cycle arrest. We applied a quantitative proteomics screen to identify signals that lead to therapy-induced senescence and discovered that Bcl2-associated athanogene 3 (Bag3) is up-regulated after adriamycin treatment in MCF7 cells. Bag3 is a member of the BAG family of co-chaperones that interacts with Hsp70. Bag3 also regulates major cell-signaling pathways. Mass spectrometry analysis of the Bag3 Complex revealed a novel interaction between Bag3 and Major Vault Protein (MVP). Silencing of Bag3 or MVP shifts the cellular response to adriamycin to favor apoptosis. We…

Relevance of Oxygen Concentration in Stem Cell Culture for Regenerative Medicine

2019

The key hallmark of stem cells is their ability to self-renew while keeping a differentiation potential. Intrinsic and extrinsic cell factors may contribute to a decline in these stem cell properties, and this is of the most importance when culturing them. One of these factors is oxygen concentration, which has been closely linked to the maintenance of stemness. The widely used environmental 21% O2 concentration represents a hyperoxic non-physiological condition, which can impair stem cell behaviour by many mechanisms. The goal of this review is to understand these mechanisms underlying the oxygen signalling pathways and their negatively-associated consequences. This may provide a rationale…

NECAB2 participates in an endosomal pathway of mitochondrial stress response at striatal synapses

2021

Synaptic signaling depends on ATP generated by mitochondria. Due to extensive connectivity, the striatum is especially vulnerable to mitochondrial dysfunction and thus requires efficient mitochondrial quality control. We found that the neuronal calcium-binding protein NECAB2 ensures synaptic function in the striatum by increasing mitochondrial efficiency. NECAB2 associates with early endosomes and mitochondria at striatal synapses. Loss of NECAB2 dysregulates proteins of the endosomal ESCRT machinery and oxidative phosphorylation. Mitochondria from NECAB2-deficient mice are more abundant but less efficient. These mitochondria exhibit increased respiration and superoxide production but produ…

Deconvolution filtering for nonlinear stochastic systems with randomly occurring sensor delays via probability-dependent method

2013

This paper deals with a robustH∞deconvolution filtering problem for discrete-time nonlinear stochastic systems with randomly occurring sensor delays. The delayed measurements are assumed to occur in a random way characterized by a random variable sequence following the Bernoulli distribution with time-varying probability. The purpose is to design anH∞deconvolution filter such that, for all the admissible randomly occurring sensor delays, nonlinear disturbances, and external noises, the input signal distorted by the transmission channel could be recovered to a specified extent. By utilizing the constructed Lyapunov functional relying on the time-varying probability parameters, the desired su…

Approximation Properties of the Modified Stancu Operators

2017

ABSTRACTIn this article we construct a sequence of Stancu-type operators that are based on a function τ. This function is any function on [0,1] continuously differentiable ∞ times, such that τ(0) =...