6533b7dafe1ef96bd126d9b5
RESEARCH PRODUCT
Relevance of Oxygen Concentration in Stem Cell Culture for Regenerative Medicine
Jose ViñaMarya El AlamiConsuelo BorrasJorge Sanz-rosMarta InglesCristina Mas BarguesAurora Román-domínguezJuan GambiniLucia Gimeno-mallenchJose Viña-almuniasubject
Senescencephysiological oxygen concentrationsenescencemedicine.medical_treatmentphysioxiaCellCell Culture TechniquesReviewBiologyRegenerative MedicineStem cell cultureRegenerative medicineCatalysisenvironmental oxygen concentrationlcsh:ChemistryInorganic ChemistryTissue engineeringmedicineAnimalsHumansCell Self RenewalPhysical and Theoretical Chemistrylcsh:QH301-705.5Molecular BiologyCellular SenescenceSpectroscopyTissue EngineeringStem CellsagingOrganic ChemistryCell DifferentiationGeneral MedicineStem-cell therapyComputer Science ApplicationsCell biologyOxygenmedicine.anatomical_structurelcsh:Biology (General)lcsh:QD1-999redoxLimiting oxygen concentrationStem cellOxidation-ReductionSignal Transductiondescription
The key hallmark of stem cells is their ability to self-renew while keeping a differentiation potential. Intrinsic and extrinsic cell factors may contribute to a decline in these stem cell properties, and this is of the most importance when culturing them. One of these factors is oxygen concentration, which has been closely linked to the maintenance of stemness. The widely used environmental 21% O2 concentration represents a hyperoxic non-physiological condition, which can impair stem cell behaviour by many mechanisms. The goal of this review is to understand these mechanisms underlying the oxygen signalling pathways and their negatively-associated consequences. This may provide a rationale for culturing stem cells under physiological oxygen concentration for stem cell therapy success, in the field of tissue engineering and regenerative medicine.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-03-01 | International Journal of Molecular Sciences |