Search results for "Signs"

showing 10 items of 314 documents

Changes in myocardial iron content following administration of intravenous iron (Myocardial‐IRON): Study design

2018

Treatment with intravenous ferric carboxymaltose (FCM) has been shown to improve symptoms, functional capacity, and quality of life in patients with heart failure and iron deficiency. However, the underlying mechanisms for these beneficial effects remain undetermined. The aim of this study is to quantify cardiac magnetic resonance changes in myocardial iron content after administration of intravenous FCM in patients with heart failure and iron deficiency and contrast them with parameters of heart failure severity. This is a multicenter, double-blind, randomized study. Fifty patients with stable symptomatic heart failure, left ventricular ejection fraction <50%, and iron deficiency will be r…

MaleTime FactorsMyocardial ironheart failure030204 cardiovascular system & hematologyFerric CompoundsSeverity of Illness IndexVentricular Function Left030218 nuclear medicine & medical imaginglaw.invention0302 clinical medicineiron deficiencyClinical ProtocolsQuality of lifeRandomized controlled triallawCardiac Magnetic Resonance Ferric Carboxymaltose Heart Failure Iron Deficiency Myocardial IronInfusions IntravenousEjection fractionAnemia Iron-DeficiencyGeneral MedicineIron deficiencyferric carboxymaltoseTreatment OutcomeResearch DesignCardiologyFemaleCardiology and Cardiovascular MedicineCardiac function curvemedicine.medical_specialtyTrial DesignsMagnetic Resonance Imaging CinePlacebocardiac magnetic resonance03 medical and health sciencesDouble-Blind MethodInternal medicinemedicineHumansMaltosemyocardial ironAgedHeart Failurebusiness.industryMyocardiumStroke VolumeRecovery of Functionmedicine.diseaseSpainHeart failureHematinicsQuality of Lifebusiness
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Testing physiologic monitor alarm customization software to reduce alarm rates and improve nurses’ experience of alarms in a medical intensive care u…

2018

BACKGROUND:Clinicians in intensive care units experience alarm fatigue related to frequent false and non-actionable alarms produced by physiologic monitors. To reduce non-actionable alarms, alarm settings may need to be customized for individual patients; however, nurses may not customize alarms because of competing demands and alarm fatigue. OBJECTIVE:To examine the effectiveness and acceptance of physiologic monitor software to support customization of alarms. METHODS:This pre/post intervention study was conducted in a 56-bed medical intensive care unit. IntelliVue® Alarm Advisor customization support software for alarm limit violations was installed on all monitors and education on its u…

MaleTime FactorsPolymersHealth Care ProvidersRespiratory Tract Diseaseslcsh:MedicineNursesBlood PressureSurveysPathology and Laboratory Medicine01 natural sciencesVascular MedicinePersonalization0302 clinical medicineSoftwareHeart RateSoftware DesignMedicine and Health SciencesMedicine030212 general & internal medicineMedical Personnellcsh:SciencePolyvinyl ChlorideMaterialsFatigueMultidisciplinarySoftware EngineeringMiddle AgedHospitalsProfessionsIntensive Care UnitsChemistryMacromoleculesResearch DesignClinical AlarmsPhysical SciencesEngineering and TechnologyEquipment FailureFemaleMedical emergencyResearch ArticleComputer and Information SciencesMaterials ScienceCardiologyResearch and Analysis MethodsCommunicable DiseasesSoftware implementation03 medical and health sciencesALARMSigns and SymptomsRespiratory RateDiagnostic MedicineIntensive careHumansIn patientArterial PressureGlasgow Coma Scale0101 mathematicsAgedMonitoring PhysiologicSurvey Researchbusiness.industrylcsh:R010102 general mathematicsGlasgow Coma Scalemedicine.diseasePolymer ChemistryHealth CareMedical intensive care unitHealth Care FacilitiesPeople and Placeslcsh:QPopulation GroupingsbusinessSoftwarePLoS ONE
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Umbilical cord blood transplantation from unrelated donors in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia

2014

Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; There are very few disease-specific studies focusing on outcomes of umbilical cord blood transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. We report the outcome of 45 patients with Philadelphia chromosome-positive acute lymphoblastic leukemia who underwent myeloablative single unit cord blood transplantation from unrelated donors within the GETH/GITMO cooperative group. Conditioning regimens were based on combinations of thiotepa, busulfan, cyclophospamide or fludarabine, and antithymocyte globulin. At the time of transplantation, 35 patients (78%) were in first complete remission, four (8%) …

MaleTransplantation Conditioning:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies [Medical Subject Headings]Leucemia-linfoma linfoblástico de células precursorasGraft vs Host Disease:Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]Supervivencia sin EnfermedadGastroenterology:Anatomy::Body Regions::Transplants::Allografts [Medical Subject Headings]:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents::Myeloablative Agonists [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]hemic and lymphatic diseasesMedicineCumulative incidenceTasa de SupervivenciaPhiladelphia ChromosomeChildCromosoma Filadelfia:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Chronic Disease [Medical Subject Headings]:Named Groups::Persons::Age Groups::Child::Child Preschool [Medical Subject Headings]ArticlesHematologyMiddle AgedPrecursor Cell Lymphoblastic Leukemia-LymphomaAllografts:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunosuppression::Transplantation Conditioning [Medical Subject Headings]FludarabineSurvival RateChild Preschool:Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings]:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Chromosome Aberrations::Translocation Genetic::Philadelphia Chromosome [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis::Disease-Free Survival [Medical Subject Headings]FemaleAcondicionamiento para el trasplanteCord Blood Stem Cell TransplantationTrasplante de células madre de la sangre del cordónmedicine.drugAloinjertosAdultmedicine.medical_specialtyAdolescent:Check Tags::Male [Medical Subject Headings]Cord Blood Stem Cell TransplantationPhiladelphia chromosomeEnfermedad injerto contra huéspedDisease-Free SurvivalEstudios retrospectivosInternal medicine:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings]:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]HumansPreschoolSurvival rate:Named Groups::Persons::Age Groups::Child [Medical Subject Headings]Retrospective Studies:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Survival Rate [Medical Subject Headings]business.industryUmbilical Cord Blood TransplantationEnfermedad crónicaAgonistas mieloablativosMyeloablative Agonistsmedicine.diseaseSettore MED/15SurgeryTransplantation:Diseases::Immune System Diseases::Graft vs Host Disease [Medical Subject Headings]:Diseases::Hemic and Lymphatic Diseases::Lymphatic Diseases::Lymphoproliferative Disorders::Leukemia Lymphoid::Precursor Cell Lymphoblastic Leukemia-Lymphoma [Medical Subject Headings]:Check Tags::Female [Medical Subject Headings]Estudios de SeguimientoChronic Disease:Analytical Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation::Cord Blood Stem Cell Transplantation [Medical Subject Headings]Adolescent; Adult; Allografts; Child; Child Preschool; Chronic Disease; Disease-Free Survival; Female; Follow-Up Studies; Graft vs Host Disease; Humans; Male; Middle Aged; Myeloablative Agonists; Retrospective Studies; Survival Rate; Cord Blood Stem Cell Transplantation; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transplantation ConditioningbusinessBusulfanFollow-Up Studies
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Validation of proposed diagnostic criteria (the "Budapest Criteria") for Complex Regional Pain Syndrome

2010

Current IASP diagnostic criteria for CRPS have low specificity, potentially leading to overdiagnosis. This validation study compared current IASP diagnostic criteria for CRPS to proposed new diagnostic criteria (the "Budapest Criteria") regarding diagnostic accuracy. Structured evaluations of CRPS-related signs and symptoms were conducted in 113 CRPS-I and 47 non-CRPS neuropathic pain patients. Discriminating between diagnostic groups based on presence of signs or symptoms meeting IASP criteria showed high diagnostic sensitivity (1.00), but poor specificity (0.41), replicating prior work. In comparison, the Budapest clinical criteria retained the exceptional sensitivity of the IASP criteria…

MaleValidation studymedicine.medical_specialtyDatabases FactualSigns and symptomsDiagnostic accuracySensitivity and SpecificityArticleDiagnosis DifferentialmedicineRegional pain syndromeHumansOverdiagnosisPain Measurementbusiness.industryReproducibility of ResultsComplex Regional Pain Syndrome Reflex sympathetic dystrophy CRPS RSD Diagnosis Validation reflex sympathetic dystrophy syndrome type-i signs crpsmedicine.diseaseSurgeryAnesthesiology and Pain MedicineComplex regional pain syndromeNeurologyPhysical therapyFemaleNeurology (clinical)businessComplex Regional Pain Syndromes
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Effect of mountain ultramarathon distance competition on biochemical variables, respiratory and lower-limb fatigue

2020

The study aimed at assessing the acute physiological effects of running a 65-km vs a 107- km mountain ultramarathon. Nineteen athletes (15 males and 4 females) from the shorter race and forty three athletes (26 males and 17 females) from the longer race were enrolled. Body weight, respiratory and lower limb strength were assessed before and after the race. Blood samples were obtained before, after and 24-h post-race. Body weight loss did not differ between races. A decrease in squat jump height (p<0.01; d = 1.4), forced vital capacity (p<0.01; d = 0.5), forced expiratory volume in 1 s (p<0.01; d = 0.6), peak inspiratory flow (p<0.01; d = 0.6) and maximal inspiratory pressure (p<0.01; d = 0.…

MaleVital capacityPhysiologyVital CapacitySocial Sciences030204 cardiovascular system & hematologyBiochemistryRunning0302 clinical medicineForced Expiratory VolumeMedicine and Health SciencesPsychologyRespiratory systemCreatine KinaseLungImmune ResponseMusculoskeletal SystemFatiguemeasurement_unitMultidisciplinarybiologyMusclesQRSports ScienceTroponinRespiratory Function TestsCorredors (Esports)Lower ExtremityCreatininemeasurement_unit.measuring_instrumentCardiologyMedicineFemaleAnatomyResearch ArticleSportsGlomerular Filtration RateAdultmedicine.medical_specialtyScienceImmunologyRenal functionBody weightLower limb03 medical and health sciencesSigns and SymptomsInternal medicinemedicineHumansMuscle StrengthPeak flow meterCardiac MusclesInflammationBehaviorRenal Physiologybusiness.industryBiological LocomotionBiology and Life SciencesProteins030229 sport sciencesRenal SystemTroponinCytoskeletal ProteinsAthletesPulmonsbiology.proteinPhysical EnduranceRecreationCreatine kinaseClinical MedicinebusinessBiomarkers
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Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact…

2022

Funder: European society of Intensive Care Medicine

Malebloodstream infections:Other subheadings::Other subheadings::/epidemiology [Other subheadings]Critical IllnessCOVID-19 (Malaltia) - EpidemiologiaRESISTANT ENTEROCOCCIBacteremiaBloodstream infectionCritical Care and Intensive Care Medicine:Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Critical Illness [DISEASES]Cohort Studies:afecciones patológicas signos y síntomas::procesos patológicos::atributos de la enfermedad::enfermedad crítica [ENFERMEDADES]Sepsis:virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES]Medicine and Health SciencesHumansNCT03937245Unitats de cures intensivesAgedCross InfectionMalalties bacterianes:infecciones bacterianas y micosis::infección::infección hospitalaria [ENFERMEDADES]Research:Otros calificadores::Otros calificadores::/epidemiología [Otros calificadores]Bacteremia; Bloodstream infection; COVID-19; Enterococcus; ICU-acquiredCOVID-19:Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES]:Bacterial Infections and Mycoses::Infection::Cross Infection [DISEASES]Intensive Care UnitsNCTICURNAICU-acquiredEnterococcus
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Effects of Constant and Doublet Frequency Electrical Stimulation Patterns on Force Production of Knee Extensor Muscles

2016

International audience; This study compared knee extensors' neuromuscular fatigue in response to two 30-minute stimulation patterns: constant frequency train (CFT) and doublet frequency train (DFT). Fifteen men underwent two separate sessions corresponding to each pattern. Measurements included torque evoked by each contraction and maximal voluntary contractions (MVC) measured before and immediately after the stimulation sessions. In addition, activation level and torque evoked during doublets (Pd) and tetanic contractions at 80-Hz (P80) and 20-Hz (P20) were determined in six subjects. Results indicated greater mean torque during the DFT stimulation session as compared with CFT. But, no dif…

MalecontractionsMuscle PhysiologyCritical Care and Emergency MedicineContraction (grammar)Knee JointRefractory Period ElectrophysiologicalPhysiologyRefractory periodKneeslcsh:MedicineStimulationKnee JointsIsometric exerciseElectromyographyPathology and Laboratory MedicineEndoplasmic Reticulum0302 clinical medicineNuclear magnetic resonanceMedicine and Health Scienceslcsh:ScienceSpinal Cord InjuryMusculoskeletal SystemTrauma MedicinePhysicsSecretory PathwayMultidisciplinarymedicine.diagnostic_test[ SDV.MHEP.PHY ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]PhysicsClassical MechanicsAnatomyNeurologyCell ProcessesPhysical SciencesMuscle FatigueLegsspinal-cord-injuryAnatomyCellular Structures and Organellesmedicine.symptomadaptationsTraumatic InjuryindividualsResearch ArticleMuscle ContractionMuscle contractionAdulthuman skeletal-muscleSurgical and Invasive Medical ProcedurestrainsMotion03 medical and health sciencesSigns and SymptomsDiagnostic MedicineIsometric ContractionSarcoplasmic Reticula[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]medicineHumansFunctional electrical stimulationMuscle SkeletalpotentiationFunctional Electrical StimulationMuscle fatigueElectromyographylcsh:RLimbs (Anatomy)Biology and Life SciencesCell Biology030229 sport sciencesElectric StimulationJoints (Anatomy)Torquerecruitmentresponseslcsh:Qfatigue030217 neurology & neurosurgery
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Sudden sensorineural hearing loss associated with inner ear lesions detected by magnetic resonance imaging.

2017

Although recent advances in magnetic resonance imaging (MRI) techniques have contributed to the detection of tiny lesions in the internal auditory canal (IAC) that may be responsible for sudden sensorineural hearing loss (SSNHL), there have been relatively few studies on the clinical characteristics of intra-labyrinthine hemorrhage (ILH) and labyrinthitis versus those regarding IAC tumors. Our purpose was to investigate the frequency of those IAC lesions on MRI and their clinical characteristics. Initial MRIs of 200 patients with SSNHL (93 men, 107 women; mean age = 48.61 years, range: 18-84 years), as well as detailed clinical histories, audiological examinations, and thyroid function, lip…

Malelcsh:MedicineOtologyAudiologyDeafnessPathology and Laboratory MedicineVascular MedicineDiagnostic Radiology0302 clinical medicineVertigoMedicine and Health Sciences030223 otorhinolaryngologylcsh:ScienceHearing DisordersParesisAged 80 and overMultidisciplinarymedicine.diagnostic_testbiologyRadiology and ImagingAudiologyMiddle AgedPrognosisMagnetic Resonance ImagingInner EarVertigoFemaleRadiologymedicine.symptomThyroid functionAnatomyResearch ArticleAdultmedicine.medical_specialtyBenign paroxysmal positional vertigoAdolescentHearing lossImaging TechniquesHearing Loss SensorineuralHemorrhageResearch and Analysis Methods03 medical and health sciencesLabyrinthitisYoung AdultSigns and SymptomsDiagnostic Medicinemedicineotorhinolaryngologic diseasesHumansAgedbusiness.industrylcsh:RBiology and Life SciencesMagnetic resonance imagingbiology.organism_classificationmedicine.diseaseOtorhinolaryngologyEarsEar InnerLesionslcsh:QAudiometrybusinessHead030217 neurology & neurosurgeryPloS one
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Socio-demographic, health-related, and individual correlates of diagnostic self-testing by lay people: Results from a representative survey in Germany

2017

Introduction A broad range of self-tests (testing for e.g. HIV, cancer, hepatitis B/C) have become available and can be conducted by lay consumers without the help of a health professional. The aims of this study were to (a) investigate the prevalence of self-testing, (b) identify the most frequently used self-tests, and (c) explore the associations between socio-demographic, health-related and individual factors with self-testing. Methods A face-to-face plus paper-pencil cross-sectional survey was conducted. The sample consisted of 2.527 respondents who were representative of the German population in terms of the age, sex, and residence. Basic descriptive statistics and univariate logistic…

Malelcsh:MedicinePathology and Laboratory MedicineLogistic regressionGeographical locationsEndocrinology0302 clinical medicineSurveys and QuestionnairesGermanyDiagnosisMedicine and Health Sciences030212 general & internal medicineComputer Networkslcsh:ScienceFatigueMultidisciplinary030503 health policy & servicesAttendanceEuropeLaypersonOncologyFemaleAnatomy0305 other medical sciencePsychologyResearch ArticleAdultComputer and Information SciencesEndocrine Disorders03 medical and health sciencesSigns and SymptomsDiagnostic MedicineMental Health and PsychiatryCancer Detection and DiagnosisDiabetes MellitusHumansEuropean UnionDemographyColorectal CancerInternetDescriptive statisticslcsh:RUnivariateCancers and NeoplasmsBiology and Life SciencesLife satisfactionKidneysRenal SystemSelf CareSocial ClassMetabolic Disorderslcsh:QResidencePeople and placesRural areaDemographyPLOS ONE
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Orthostatic Changes in Blood Pressure and Cognitive Status in the Elderly: The Progetto Veneto Anziani Study.

2016

We studied a cohort of 1408 older subjects to explore whether postural changes in blood pressure (BP; defined as orthostatic hypo- or hypertension) can predict the onset of cognitive deterioration. Orthostatic hypotension was defined as a drop of 20 mm Hg in systolic or 10 mm Hg in diastolic BP and orthostatic hypertension as a rise of 20 mm Hg in systolic BP. Orthostatic BP values were grouped into quintiles for secondary analyses. Two cognitive assessments were considered: (1) cognitive impairment, that is, Mini-Mental State Examination scores ≤24/30, and (2) cognitive decline (CD), that is, a 3-point decrease in Mini-Mental State Examination score from the baseline to the follow-up. At t…

Malemedicine.medical_specialtyAgingPostureDiastoleBlood Pressure030204 cardiovascular system & hematologyNeuropsychological TestselderlyRisk AssessmentNOorthostatic hypotension03 medical and health sciencesOrthostatic vital signsHypotension Orthostatic0302 clinical medicineCognitionInternal medicinemedicineInternal MedicinePrevalenceHumansCognitive DysfunctionCognitive declinecognitive impairmentAgedorthostatic hypertensionPsychiatric Status Rating Scalesbusiness.industryConfoundingBlood Pressure DeterminationOdds ratioPrognosisBlood pressureItalyCohortHypertensionCardiologyPhysical therapyFemaleblood pressure; cognition; cognitive impairment; elderly; orthostatic hypertension; orthostatic hypotension; Internal MedicineOrthostatic hypertensionmedicine.symptombusinessCognition Disorders030217 neurology & neurosurgeryHypertension (Dallas, Tex. : 1979)
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