Search results for "Silent"
showing 10 items of 53 documents
Silent and symptomatic atrial fibrillation,during the acute phase of myocardial infarction : determinants and role of arginine methylated and oxidati…
2015
Atrial fibrillation (AF) is a frequent complication of acute myocardial infarction (AMI) with a poorer prognosis. Silent atrial fibrillation has been suggested to be frequent after AMI. However, most part of the studies has targeted only paroxysmal or persistent AF. Thus, Reduced Nitric Oxide availability and endothelial dysfunction has been recently recognized as a possible contributor to altered prognosis in AF. Asymmetric dimethylarginine (ADMA) can inhibit nitric oxide synthase and leads to endothelial dysfunction, inflammation and oxidative stress in multiple cardiovascular diseases. However, any study has addressed the relationship between ADMA levels and the occurrence of AF in AMI.W…
Systematic screening for mutations in the promoter and the coding region of the 5-HT1A gene.
1995
In the present study we sought to identify genetic variation in the 5-HT{sub 1A} receptor gene which through alteration of protein function or level of expression might contribute to the genetic predisposition to neuropsychiatric diseases. Genomic DNA samples from 159 unrelated subjects (including 45 schizophrenic, 46 bipolar affective, and 43 patients with Tourette`s syndrome, as well as 25 healthy controls) were investigated by single-strand conformation analysis. Overlapping PCR (polymerase chain reaction) fragments covered the whole coding sequence as well as the 5{prime} untranslated region of the 5-HT{sub 1A} gene. The region upstream to the coding sequence we investigated contains a …
Genetic manipulation of longevity-related genes as a tool to regulate yeast life span and metabolite production during winemaking
2013
Abstract Background Yeast viability and vitality are essential for different industrial processes where the yeast Saccharomyces cerevisiae is used as a biotechnological tool. Therefore, the decline of yeast biological functions during aging may compromise their successful biotechnological use. Life span is controlled by a variety of molecular mechanisms, many of which are connected to stress tolerance and genomic stability, although the metabolic status of a cell has proven a main factor affecting its longevity. Acetic acid and ethanol accumulation shorten chronological life span (CLS), while glycerol extends it. Results Different age-related gene classes have been modified by deletion or o…
Ābrahāma klusēšana Sērena Kirkegora darbā "Bailes un trīsas"
2022
Sērena Kirkegora darbs “Bailes un trīsas” varētu būt viens no lasītākajiem Kirkegora darbiem. Kaut arī tā interpretācijas ir dažādas, ko autors nodrošina, nesniedzot tiešus skaidrojumus tam, kā būtu saprotams viņa darbs, tomēr kā vienu no darba mērķiem varam lasīt: “saprast Ābrahāmu”. Būtiska loma, tuvojoties šādai izpratnei, ir Ābrahāma klusēšanai — tā ir tēma, kas caurvij visu Kirkegora darbu un pat nonāk darba noslēdzošās nodaļas — “III problēma: Vai ir ētiski attaisnojams tas, ka Ābrahāms noklusēja savu darāmo no Sāras, no Ēliēzera, no Īzāka?” — nosaukumā. Šī pētījuma iecere ir uzrādīt un analizēt dažādos veidus, kā darbā “Bailes un trīsas” tiek runāts par klusēšanu, lai pamatotu to, ka…
Effects of caffeine on neuromuscular function in a non‐fatigued state and during fatiguing exercise
2020
New findings What is the central question of the study? What are the effects of caffeine on neuromuscular function in a non-fatigued state and during fatiguing exercise? What is the main finding and its importance? In a non-fatigued state, caffeine decreased the duration of the silent period evoked by transcranial magnetic stimulation. Caffeine-induced reduction of inhibitory mechanisms in the central nervous system before exercise was associated with an increased performance. Individuals who benefit from caffeine ingestion may experience lower perception of effort during exercise and an accelerated recovery of M-wave amplitude postfatigue. This study elucidates the mechanisms of action of …
Central alterations of neuromuscular function and feedback from group III-IV muscle afferents following exhaustive high-intensity one-leg dynamic exe…
2015
The aims of this investigation were to describe the central alterations of neuromuscular function induced by exhaustive high-intensity one-leg dynamic exercise (OLDE, study 1) and to indirectly quantify feedback from group III-IV muscle afferents via muscle occlusion (MO, study 2) in healthy adult male humans. We hypothesized that these central alterations and their recovery are associated with changes in afferent feedback. Both studies consisted of two time-to-exhaustion tests at 85% peak power output. In study 1, voluntary activation level (VAL), M-wave, cervicomedullary motor evoked potential (CMEP), motor evoked potential (MEP), and MEP cortical silent period (CSP) of the knee extensor…
Priming the Motor Cortex With Anodal Transcranial Direct Current Stimulation Affects the Acute Inhibitory Corticospinal Responses to Strength Trainin…
2019
Frazer, AK, Howatson, G, Ahtiainen, JP, Avela, J, Rantalainen, T, and Kidgell, DJ. Priming the motor cortex with anodal transcranial direct current stimulation affects the acute inhibitory corticospinal responses to strength training. J Strength Cond Res 33(2): 307-317, 2019-Synaptic plasticity in the motor cortex (M1) is associated with strength training (ST) and can be modified by transcranial direct current stimulation (tDCS). The M1 responses to ST increase when anodal tDCS is applied during training due to gating. An additional approach to improve the M1 responses to ST, which has not been explored, is to use anodal tDCS to prime the M1 before a bout of ST. We examined the priming effe…
Motor intracortical inhibition in PD: L-DOPA modulation of high-frequency rTMS effects
2007
Dopaminergic drugs and deep brain stimulation restore cortical inhibition in Parkinson disease (PD) patients. High-frequency rTMS was also found to increase cortical inhibition in PD but its therapeutic effect is still controversial. Here we hypothesize that, if dopaminergic drugs reverse to normal cortical excitability in M1, the effect of high-frequency (hf)-rTMS in PD patients could depend on whether they are in a medicated or unmedicated state. The present study aims to explore the lasting effects of sub-threshold hf rTMS trains over M1 on cortical inhibition in patients with "on" and without "off" L-DOPA treatment. Fourteen PD patients were examined twice while "on" and "off" medicatio…
Simultaneous identification of campylobacters and prediction of quinolone resistance by comparative sequence analysis.
1997
Comparative sequence analysis of a 30-bp segment in the quinolone resistance-determining region of campylobacters not only allows for the detection of base changes associated with resistance but also is a powerful tool for species identification based on silent mutations.
Silent music reading: Amateur musicians' visual processing and descriptive skill
2013
This article addresses the silent reading of music notation, combining eye-movement measures with a semantic analysis of readers’ verbal descriptions of the notated music. A group of musical novices ( n = 16) and two groups of musical amateurs (less experienced n = 11 and more experienced n = 10) participated in three separate measurement sessions during a nine-month-long university music course designed for future primary-school teachers. In each session they viewed a notated folk song for 30 s and then described what they had seen. Greater musical experience was found to be connected with shorter fixation durations, more linear scanning of the notated music, and more accurate and integra…