Search results for "Simulation"
showing 10 items of 5095 documents
On Fuzzy Stochastic Integral Equations—A Martingale Problem Approach
2011
In the paper we consider fuzzy stochastic integral equations using the methods of stochastic inclusions. The idea is to consider an associated martingale problem and its solutions in order to obtain a solution to the fuzzy stochastic equation.
Studies on a new potential dopaminergic agent: in vitro BBB permeability, in vivo behavioural effects and molecular docking evaluation.
2015
2-Amino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-phenyl-propionamide (DA-PHEN) has been previously synthesized to obtain a potential prodrug capable of release dopamine (DA) into CNS. However, DA-PHEN could act per se as a dopaminergic drug. In this study, the permeability transport (Pe), obtained by parallel artificial permeability assay (PAMPA), indicated a low passive transcellular transport (Pe = 0.32 ± 0.01 × 10(-6 )cm/s). Using the Caco-2 cell system, the Papp AP-BL in absorptive direction (3.36 ± 0.02 × 10(-5 )cm/s) was significantly higher than the Papp BL-AP in secretive direction (1.75 ± 0.07 × 10(-5 )cm/s), suggesting a polarized transport. The efflux ratio (Papp AP-BL/Papp BL-AP = 0…
Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and Downregulation of c-Myc.
2021
11 p.-9 fig.-4 tab.
Mindfulness, inattention and performance in a driving simulator
2015
The following study will explore the link between mindfulness, driver inattention and a number of driving performance variables that were tested using the SIMUVEG driving simulator. 67 subjects between the ages of 19 and 27 completed the mindful attention awareness scale, attention-related driving errors scale and attention-related cognitive errors scale questionnaires, and were evaluated in two driving performance measures: time to line-crossing and mean speed. The results did not show a correlation between driving performance and mindfulness measures; they did show low but significant correlations with driver inattention measures. A regression analysis suggested that the specific measure …
Effect of cultivation techniques on the hydrodynamic and mechanical behaviour of the "Lauragais-terreforts"
1993
The effect of various seed bed preparations on hydrodynamic and mechanical parameters was studied experimentally by simulated rainfall on clayeyloamy soils Lauragais, which had developed on chalky molasse on a slope greater than 12 %. The level of soaked up rain ("pluie d'imbibition", Pi) is closely connected to the inital degree of saturation of the soil ; it varies from 10 to 24 mm when the soil is humid and increases when the soil is dry (14 to 47 mm). But when the soil surface is crusted the Pi is less and seems to be no longer controlled by the degree of water in the soil. Treatments with fine structural elements show the fewest possibilities of infiltration during the soaking up stage…
Simulated raindrop's characteristic measurements. A new approach of image processing tested under laboratory rainfall simulation
2018
Abstract The size of the drops determines soil erosion and runoff rates, and then the fate of ecosystems. Various raindrop measurement techniques and tools have been developed to determine natural and simulated raindrop size distributions and mean drop size. There is a need to improve the procedure to determine the raindrop properties, and this is why we develop a new technique to analyze drop size distribution and fall velocity. For this purpose a rainfall simulator with two oscillating Veejet 80100 nozzles in laboratory condition, and high speed imaging technique and edge detection approach in image processing was applied to identify and measure drop size and calculate drop velocity. The …
Protocol for rational design of covalently interacting inhibitors.
2014
The inhibition potencies of covalent inhibitors mainly result from the formation of a covalent bond to the enzyme during the inhibition mechanism. This class of inhibitors has essentially been ignored in previous target-directed drug discovery projects because of concerns about possible side effects. However, their advantages, such as higher binding energies and longer drug-target residence times moved them into the focus of recent investigations. While the rational design of non-covalent inhibitors became standard the corresponding design of covalent inhibitors is still in its early stages. Potent covalent inhibitors can be retrieved from large compound libraries by covalent docking approa…
Pharmacogenomic and molecular docking studies on the cytotoxicity of the natural steroid wortmannin against multidrug-resistant tumor cells
2014
Wortmannin is a cytotoxic compound derived from the endophytic fungi Fusarium oxysporum, Penicillium wortmannii and Penicillium funiculosum that occurs in many plants, including medicinal herbs. The rationale to develop novel anticancer drugs is the frequent development of tumor resistance to the existing antineoplasic agents. Therefore, it is mandatory to analyze resistance mechanisms of novel drug candidates such as wortmannin as well to bring effective drugs into the clinic that have the potential to bypass or overcome resistance to established drugs and to substantially increase life span of cancer patients. In the present project, we found that P-glycoprotein-overexpressing tumor cells…
Computer simulations for bioequivalence trials: selection of analyte in BCS drugs with first-pass metabolism and two metabolic pathways.
2010
The objective of this work is to use a computer simulation approach to define the most sensitive analyte for in vivo bioequivalence studies of all types of Biopharmaceutics Classification System (BCS) drugs undergoing first-pass hepatic metabolism with two metabolic pathways. A semi-physiological model was developed in NONMEM VI to simulate bioequivalence trials. Four BCS classes (from Class I to IV) of drugs, with three possible saturation scenarios (non-saturation, saturation and saturation of only the major route of metabolism), two (high or low) dose schemes, and six types of pharmaceutical quality for the drug products were simulated. The number of investigated scenarios was 144 (4 × 3…
Computer simulations of bioequivalence trials: selection of design and analyte in BCS drugs with first-pass hepatic metabolism: linear kinetics (I).
2008
Modeling and simulation approaches are useful tools to assess the potential outcome of different scenarios in bioequivalence studies. The aim of this study is to propose a new and improved semi-physiological model for bioequivalence trial simulations and apply it for all BCS (Biopharmaceutic Classification System) drug classes with non-saturated first-pass hepatic metabolism. The semi-physiological model was developed in NONMEM VI to simulate bioequivalence trials. Parent drug and metabolite levels for both reference and test were simulated. Eight types of drugs (with high or low permeability and high or low solubility (class I to IV) and high or low intrinsic clearance) were considered in …