Search results for "Single"

showing 10 items of 4920 documents

Dynamics of Polar Clusters in PMN Ceramics: Comparison with PMN Single Crystal

2006

The dielectric permittivity of PMN ceramics was measured in the frequency range from 20 Hz to 37 GHz. From the frequency dependence of the real and imaginary parts of dielectric permittivity, the distribution of relaxation times f(τ) was calculated. The f(τ) function broadens significantly, and the second maximum appears below the 270 K temperature. The dielectric response and also relaxation time distribution of PMN ceramics was compared with the previous results of PMN single crystal. The results showed that dynamics of polar nano regions in PMN ceramics is suppressed due to the small size of grains in the ceramics.

PermittivityMaterials scienceCondensed matter physicsRelaxation (NMR)Dynamics (mechanics)Condensed Matter PhysicsGrain sizeElectronic Optical and Magnetic Materialsvisual_artNano-visual_art.visual_art_mediumPolarCeramicSingle crystalFerroelectrics
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Monte Carlo Simulations of Semi-Flexible Polymers

2005

We present Monte Carlo simulations on the phase behavior of semiflexible macromolecules. For a single chain this question is of biophysical interest given the fact that long and stiff DNA chains are typically folded up into very tight compartments. So one can ask the question how the state diagram of a semiflexible chain differs from the coilglobule behavior of a flexible macromolecule. Another effect connected with rigidity of the chains is their tendency to aggregate and form nematically ordered structures. As a consequence one has two competing phase transitions: a gas-liquid and an isotropic-nematic transition potentially giving rise to a complicated phase diagram.

Persistence lengthchemistry.chemical_classificationQuantitative Biology::BiomoleculesPhase transitionChemistryMonte Carlo methodSingle chainPolymerQuantitative Biology::Subcellular ProcessesCondensed Matter::Soft Condensed MatterRigidity (electromagnetism)Statistical physicsMacromoleculePhase diagram
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PERSPECTIVE RESTITUTION FROM VIEW CAMERAS PHOTOS

2022

Abstract. The paper aims at discussing the accuracy of perspective restitution from view camera photos; view cameras are non-standard cameras frequently used in the past century for on field shooting of buildings and urban sites; this is why the reconstruction of lost buildings often deals with photos taken with a view camera. The case study chosen for the proposed experiment is an urban complex built in Palermo in the ‘50s. The site features a very regular layout with surfaces at right angle, that supports the graphic reconstruction of photos’ inner and outer orientation. The site has been surveyed with a laser scanner; the point cloud provided the metric information needed for the evaluat…

Perspective restitution Single image photogrammetry Period photos View Camera Virtual reconstruction.ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISIONSettore ICAR/17 - DisegnoThe International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
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Fine Structure of the Tunic ofCiona intestinalisL. II. Tunic morphology, cell distribution and their functional importance

1981

Ciona intestinalis L. tunic architecture and cell distribution were investigated with the electron microscope. The observations showed that the ascidian covering is formed by a thin outer cuticle, a subcuticle of variable width and a large single layer of ground substance. “Large granule”, morula, phagocyte and granulocyte are the cellular types encountered; they appear mainly in highly vacuolated states and are distributed throughout the whole tunic. The “large granule” cells, however, are mainly seen in the cuticle layer and the morula cells appear mostly in the outer zone of the ground substance. The role of these cells in tunic construction, repair and regeneration as well as their scav…

PhagocyteCellGranule (cell biology)Ground substanceCell BiologyAnatomyBiologybiology.organism_classificationCell biologylaw.inventionmedicine.anatomical_structureFunctional importancelawembryonic structuresmedicineAnimal Science and ZoologyCiona intestinalisElectron microscopeEcology Evolution Behavior and SystematicsSingle layerActa Zoologica
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Synthesis and photocytotoxic activity of [1,2,3]triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines

2018

Abstract [1,2,3]Triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines were synthesized with the aim to investigate their photocytotoxic activity. Upon irradiation, oxazolo-naphtapyridines induced light-dependent cell death at nanomolar/low micromolar concentrations (EC50 0.01–6.59 μM). The most photocytotoxic derivative showed very high selectivity and photocytotoxicity indexes (SI = 72–86, PTI>5000), along with a triplet excited state with exceptionally long lifetime (18.0 μs) and high molar absorptivity (29781 ± 180 M−1cm−1 at λmax 315 nm). The light-induced production of ROS promptly induced an unquenchable apoptotic process selectively in tumor cells, with mitoch…

Pharmaceutical ScienceApoptosisMitochondrionPhotochemiotherapy; Photosensitizing agents; Reactive oxygen species; [123]Triazolo[45-h][16]naphthyridines; [13]oxazolo[54-h][16]naphthyridines; Pharmacology; Drug Discovery; Pharmaceutical Science; Organic Chemistry01 natural sciencesMedicinal chemistry[13]oxazolo[54-h][16]naphthyridinechemistry.chemical_compoundDrug Discovery6]naphthyridineschemistry.chemical_classification0303 health sciencesTumorPhotosensitizing AgentsCell DeathSinglet OxygenSinglet oxygenPhotochemiotherapy; Photosensitizing agents; Reactive oxygen species; [1; 2; 3]Triazolo[4; 5-h][1; 6]naphthyridines; [1; 3]oxazolo[5; 4-h][1; 6]naphthyridines; Apoptosis; Cell Death; Cell Line; Tumor; Humans; Lysosomes; Mitochondria; Naphthyridines; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; Singlet OxygenGeneral MedicineLysosomeMitochondriaExcited stateReactive oxygen specie5-h][1HumanProgrammed cell death2NaphthyridinePhotochemiotherapy3]Triazolo[4Cell Line03 medical and health sciences4-h][1Cell Line TumorHumansNaphthyridines030304 developmental biologyPharmacologyReactive oxygen speciesPhotosensitizing agent010405 organic chemistryOrganic ChemistryApoptosi0104 chemical sciences3]oxazolo[5chemistryPhotochemotherapyCell cultureApoptosis[123]Triazolo[45-h][16]naphthyridine[1LysosomesReactive Oxygen SpeciesDerivative (chemistry)
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Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study

2011

Genetic variants of the alcohol-metabolizing enzyme ADH4, located on chromosome 4q22-4q23, have been related to alcohol dependence (AD) risk in previous research. The aim of this association study in a large multicenter sample of alcohol-dependent individuals and controls is to confirm ADH4 single nucleotide polymorphism (SNP) and haplotype association with AD and relevant related phenotypes. One thousand, six hundred and twenty-two (1622) inpatient subjects and 1469 control subjects with DSM-IV. AD from four addiction treatment centres were included. Characteristics of AD and related phenotypes including alcohol withdrawal, Cloninger's type I and II and first ages of drinking, regular drin…

PharmacologyGeneticsPsychiatry and Mental healthADH4HaplotypeAlcohol dependenceMedicine (miscellaneous)SNPADH1BSingle-nucleotide polymorphismBiologyPhenotypeALDH2Addiction Biology
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Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster

2011

Alcohol dependence (AD) is an important contributory factor to the global burden of disease. The etiology of AD involves both environmental and genetic factors, and the disorder has a heritability of around 50%. The aim of the present study was to identify susceptibility genes for AD by performing a genome-wide association study (GWAS). The sample comprised 1333 male in-patients with severe AD according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, and 2168 controls. These included 487 patients and 1358 controls from a previous GWAS study by our group. All individuals were of German descent. Single-marker tests and a polygenic score-based analysis to assess the …

PharmacologyGeneticsPsychiatry and Mental healthLinkage disequilibriumPolymorphism (computer science)Gene clusterMedicine (miscellaneous)SNPADH1BSingle-nucleotide polymorphismGenome-wide association studyBiologyHeritabilityAddiction Biology
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Die Wirkung von Harmalin auf die Konzentration von Noradrenalin und Adrenalin im Herzen

1959

A single injection of harmaline increases the noradrenaline and adrenaline concentration in the rat heart. The maximum effect is obtained after about 40 min.

PharmacologyHeart pharmacologyChemistryCell BiologyRat heartSingle injectionPharmacologyCellular and Molecular NeuroscienceHarmalinechemistry.chemical_compoundEpinephrine metabolismMolecular MedicineNorepinephrine metabolismMolecular BiologyExperientia
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Renale Wasser- und Elektrolytausscheidung durstender Ratten innerhalb von 32 Stunden nach einmaliger intraven�ser Gabe von Chlormerodrin oder Mersalyl

1959

At the beginning of a period of hunger and thirst, rats received 3 or 4,5 to 5 mg.Hg/kg. as chlormerodrine or mersalyl. The optimal dose of 3mg Hg/kg.as chlormerodrine or 4,5mg. Hg/kg. as mersalyl was effective for more than 32 hours after a single injection.

PharmacologyIntravenous dosebusiness.industryGeneral MedicineSingle injectionPharmacologyElectrolyte excretionMersalylThirstchemistry.chemical_compoundchemistryChlormerodrineRenal physiologyMedicineChlormerodrinmedicine.symptombusinessNaunyn-Schmiedeberg's Archiv f�r Experimentelle Pathologie und Pharmakologie
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Ketorolac beats ketoprofen: lower photodecarboxylation, photohemolysis and phototoxicity

2013

Ketorolac shows reduced photohemolytic activity and low phototoxicity against human skin fibroblasts when compared to ketoprofen. The low decarboxylation quantum yield together with the efficient non-radiative deactivation of the triplet and singlet excited states of ketorolac are believed to be responsible for this behaviour.

PharmacologyKetoprofenDecarboxylationChemistryOrganic ChemistryPharmaceutical ScienceQuantum yieldHuman skinPharmacologyPhotochemistryBiochemistryKetorolacExcited stateDrug DiscoverymedicineMolecular MedicineSinglet statePhototoxicitymedicine.drugMedChemComm
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