6533b85afe1ef96bd12b8b20
RESEARCH PRODUCT
Ketorolac beats ketoprofen: lower photodecarboxylation, photohemolysis and phototoxicity
Chiara FascianiJosé Carlos Netto-ferreiraJosé Carlos Netto-ferreiraMaría González-béjarDaniel Roca-sanjuánChristopher D. MctiernanEmilio I. Alarconsubject
PharmacologyKetoprofenDecarboxylationChemistryOrganic ChemistryPharmaceutical ScienceQuantum yieldHuman skinPharmacologyPhotochemistryBiochemistryKetorolacExcited stateDrug DiscoverymedicineMolecular MedicineSinglet statePhototoxicitymedicine.drugdescription
Ketorolac shows reduced photohemolytic activity and low phototoxicity against human skin fibroblasts when compared to ketoprofen. The low decarboxylation quantum yield together with the efficient non-radiative deactivation of the triplet and singlet excited states of ketorolac are believed to be responsible for this behaviour.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-01 | MedChemComm |