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Real-time detection of BRAF V600E mutation from archival hairy cell leukemia FFPE tissue by nanopore sequencing
2018
The MinION is a miniaturized high-throughput next generation sequencing platform of novel conception. The use of nucleic acids derived from formalin-fixed paraffin-embedded samples is highly desirable, but their adoption for molecular assays is hurdled by the high degree of fragmentation and by the chemical-induced mutations stemming from the fixation protocols. In order to investigate the suitability of MinION sequencing on formalin-fixed paraffin-embedded samples, the presence and frequency of BRAF c.1799T > A mutation was investigated in two archival tissue specimens of Hairy cell leukemia and Hairy cell leukemia Variant. Despite the poor quality of the starting DNA, BRAF mutation was su…
Single tube optimisation of APOE genotyping based on melting curve analysis
2008
Objectives: To develop and validate a single-tube protocol for APOE genotyping using fluorescent probes. Design and methods: We have designed and validated a hybrid, single-tube, SimpleProbe/FRET probe protocol that takes advantage of the different probe wavelength emissions. Results: Our method offers high quality outcomes, minimum interferences between probe signals and is 100% concordant with the reference protocol. Conclusions: This method is cheaper, faster and more reliable and versatile than other alternatives proposed. © 2008 Elsevier Inc. All rights reserved.
A novel oxalate-based three-dimensional coordination polymer showing magnetic ordering and high proton conductivity
2017
A novel three-dimensional (3D) coordination polymer with the formula (C3N2H5)4[MnCr2(ox)6]·5H2O (2), where ox = oxalate and C3N2H5 = imidazolium cation, is reported. Single crystal X-ray diffraction reveals that this porous coordination polymer adopts a chiral three-dimensional quartz-like architecture, with the guest imidazolium cations and water molecules being hosted in its pores. This novel multifunctional material exhibits both a ferromagnetic ordering at TC = 3.0 K, related to the host MnCr2 network, and high proton conductivity [1.86 × 10−3 S cm−1 at 295 K and 88% relative humidity (RH)] due to the presence of the acidic imidazolium cations and free water molecules. The similarity of…
"Table 1" of "Search for supersymmetry with jets, missing transverse momentum and at least one hadronically decaying $\tau$ lepton in proton-proton c…
2012
Distribution of the missing transverse energy before final selection requirement on the effective mass. Tabulated are the observed Data events, the Standard Model predictions and the expected rates for two signal scenarios with Lambda=30TeV / tan(beta) = 20 and Lambda=40GeV / tan(beta)=30 respectively.
"Table 2" of "Search for squarks and gluinos with the ATLAS detector in final states with jets and missing transverse momentum using 4.7 fb^-1 of sqr…
2012
The meff_incl distribution in Signal Region Ap.
"Table 1" of "Search for squarks and gluinos with the ATLAS detector in final states with jets and missing transverse momentum using 4.7 fb^-1 of sqr…
2012
The meff_incl distribution in Signal Region A.
"Table 5" of "Search for squarks and gluinos with the ATLAS detector in final states with jets and missing transverse momentum using 4.7 fb^-1 of sqr…
2012
The meff_incl distribution in Signal Region D.
"Table 4" of "Search for squarks and gluinos with the ATLAS detector in final states with jets and missing transverse momentum using 4.7 fb^-1 of sqr…
2012
The meff_incl distribution in Signal Region C.
"Table 6" of "Search for squarks and gluinos with the ATLAS detector in final states with jets and missing transverse momentum using 4.7 fb^-1 of sqr…
2012
The meff_incl distribution in Signal Region E.
"Table 3" of "Search for squarks and gluinos with the ATLAS detector in final states with jets and missing transverse momentum using 4.7 fb^-1 of sqr…
2012
The meff_incl distribution in Signal Region B.