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On the origin of mongrels: evolutionary history of free-breeding dogs in Eurasia

2015

Although a large part of the global domestic dog population is free-ranging and free-breeding, knowledge of genetic diversity in these free-breeding dogs (FBDs) and their ancestry relations to pure-breed dogs is limited, and the indigenous status of FBDs in Asia is still uncertain. We analyse genome-wide SNP variability of FBDs across Eurasia, and show that they display weak genetic structure and are genetically distinct from pure-breed dogs rather than constituting an admixture of breeds. Our results suggest that modern European breeds originated locally from European FBDs. East Asian and Arctic breeds show closest affinity to East Asian FBDs, and they both represent the earliest branching…

AsiaPopulationPolymorphism Single NucleotideGeneral Biochemistry Genetics and Molecular BiologyDogsGenetic variationAnimalsEast AsiaeducationResearch ArticlesGeneral Environmental ScienceGenetic diversityeducation.field_of_studyMiddle EastGeneral Immunology and MicrobiologyC182 EvolutionGenetic VariationGeneral MedicineBiological EvolutionGenealogyEuropePhylogeographyPhylogeographyGenetics PopulationAncient DNAGeographyEvolutionary biologyGenetic structureGeneral Agricultural and Biological SciencesGenome-Wide Association StudyProceedings of the Royal Society B: Biological Sciences

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In silico and in vitro comparative analysis to select, validate and test SNPs for human identification.

2007

Abstract Background The recent advances in human genetics have recently provided new insights into phenotypic variation and genome variability. Current forensic DNA techniques involve the search for genetic similarities and differences between biological samples. Consequently the selection of ideal genomic biomarkers for human identification is crucial in order to ensure the highest stability and reproducibility of results. Results In the present study, we selected and validated 24 SNPs which are useful in human identification in 1,040 unrelated samples originating from three different populations (Italian, Benin Gulf and Mongolian). A Rigorous in silico selection of these markers provided …

Asialcsh:QH426-470lcsh:BiotechnologyIn silicoPolymorphism Single Nucleotide; Heterozygote Detection; Gene Frequency; Humans; Africa; Europe; Computational Biology; Sequence Analysis DNA; Forensic Anthropology; Asia; Chromosome MappingSingle-nucleotide polymorphismBiologyHeterozygote DetectionGenomePolymorphism Single NucleotideGene Frequencylcsh:TP248.13-248.65GeneticsHumansPolymorphismAllele frequencySelection (genetic algorithm)GeneticsGenetic Carrier ScreeningChromosome MappingComputational BiologySingle NucleotideDNASequence Analysis DNAHuman geneticsEuropelcsh:GeneticsSettore MED/03 - Genetica MedicaAfricaSNPs HUMAN IDENTIFICATION comparative analysisForensic AnthropologyHuman genomeDNA microarraySequence AnalysisBiotechnologyResearch ArticleBMC genomics

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The mitochondrial‐derived peptide MOTS ‐c: a player in exceptional longevity?

2015

Mitochondrial-derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA-c (MOTS-c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS-c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people. 5.760 JCR (2015) Q1, 36/187 Cell biology, 3/49 Geriatrics & gerontology UEM

Asian Continental Ancestry GroupAgingMitochondrial DNAMitochondrial-Derived Peptide MOTS-cBiologíamedia_common.quotation_subjectLongevityMolecular biology of agingmitochondrial DNAGenética humanaMitochondrionBiologyDNA MitochondrialPolymorphism Single Nucleotidelongevity geneOpen Reading FramesAsian PeopleJapanCentenariansHumansmolecular biology of agingBiología humanaHumaninmedia_commonGeneticsBiología molecularGenMitochondrial DNA abnormalitiesLongevityCell Biologylongevity regulationLongevity geneMitochondrial DNAmitochondrial DNA abnormalitiesMitochondriaLongevity regulationOpen reading frameRNA RibosomalCommentaryAsian populationcentenariansPeptidesAging Cell

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Dentatorubral-pallidoluysian atrophy: haplotype of Asian origin in 2 Italian families.

2011

Asian originMaleNerve Tissue ProteinsBiologyDentatorubral-pallidoluysian atrophyPolymorphism Single NucleotideGeneticAsian PeoplePolymorphism (computer science)medicineHumansGenetic Association StudiesFamily healthGeneticsFamily HealthDentatorubral-pallidoluysian atrophyHaplotypemedicine.diseaseMyoclonic Epilepsies ProgressiveItalian familiesNeurologyHaplotypesItalySettore MED/26 - NeurologiaFemaleNeurology (clinical)Microsatellite RepeatsMovement disorders : official journal of the Movement Disorder Society

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Electroweak baryogenesis from a dark sector

2017

Adding an extra singlet scalar $S$ to the Higgs sector can provide a barrier at tree level between a false vacuum with restored electroweak symmetry and the true one. This has been demonstrated to readily give a strong phase transition as required for electroweak baryogenesis. We show that with the addition of a fermionic dark matter particle $\chi$ coupling to $S$, a simple UV-complete model can realize successful electroweak baryogenesis. The dark matter gets a CP asymmetry that is transferred to the standard model through a $CP\ portal\ interaction$, which we take to be a coupling of $\chi$ to $\tau$ leptons and an inert Higgs doublet. The CP asymmetry induced in left-handed $\tau$ lepto…

Astrophysics and AstronomyParticle physicsCosmology and Nongalactic Astrophysics (astro-ph.CO)standard model of particle physicsPhysics beyond the Standard ModelSTANDARD MODELFOS: Physical sciences01 natural sciences7. Clean energy114 Physical sciencesdark matterHiggs sectorStandard Modelpimeä aineHigh Energy Physics - Phenomenology (hep-ph)Baryon asymmetry0103 physical sciencesSINGLET010306 general physicsParticle Physics - PhenomenologyPhysicsta114010308 nuclear & particles physicsElectroweak interactionHigh Energy Physics::Phenomenologyhiukkasfysiikan standardimalliRADIATIVE NEUTRINO MASShep-phSphaleronBaryogenesisHigh Energy Physics - Phenomenologyastro-ph.COHiggs bosonPHASE-TRANSITIONHigh Energy Physics::ExperimentMATTERAstrophysics - Cosmology and Nongalactic Astrophysics

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