Search results for "Small"
showing 10 items of 2441 documents
Competence needs of older worker in small and medium size enterprises
2000
Ethical Behavior and Organizational Innovation: Analysis of Small and Medium-Sized Enterprises in Latvia
2018
Abstract Innovations can provide small and medium-sized enterprises (SMEs) a significant competitive advantage considering the ambiguous business environment. SMEs may face lower capacity and more constrained funding for long-term investments, however, understanding innovation in a broader sense and looking into organizational structures, behaviors and processes, SMEs have an opportunity to become more competitive. This study analyzes the impact of ethical behavior as a part of an organizational culture on organizational innovation performance in SMEs. Six hundred SMEs in Latvia were surveyed to assess whether employees follow the principles of business ethics in their work and what is the …
Expressing perception in parallel ways. Sentential Small Clauses in German and Romance
2021
This chapter compares Pseudo-relatives (‘PRs’), a construction found in most Romance languages, with ‘Subject-wieclauses’ (‘SWs’), a German construction in which the subject of an embedded wie-clause precedes the complementizer wie (‘how’; e.g. Ich sah Maria, wie sie sang, lit. “I saw Mary, how she sung”, i.e. ‘I saw Mary singing’). We show that both constructions mainly occur with perception verbs, and that they have a very similar syntactic behaviour; e.g., they can be coordinated with adjectival or prepositional small clauses and have anaphoric tense. Furthermore, they both have a clausal nature but can modify a DP. We thus propose to extend Casalicchio’s (2016) analysis of PRs to SWs: t…
Zakres informacyjny uproszczonego sprawozdania finansowego jednostki małej
2015
W związku z implementacją zapisów nowej dyrektywy rachunkowości celem artykułu jest prezentacja zmian wprowadzonych w nowelizacji ustawy o rachunkowości z dnia 23 września 2015 r. Autorka określa ich wpływ na zakres informacyjny uproszczonego sprawozdania finansowego jednostki małej. Do rozwiązania przedstawionego problemu badawczego wykorzystano metodę analizy treści regulacji prawnych (krajowych i międzynarodowych) oraz metody porównań i wnioskowania. Nowelizacja ustawy o rachunkowości, wprowadzona w życie 23 września 2015 r., w myśl implementacji dyrektywy 2013/34/UE, ma na celu poprawę warunków wykonywania działalności gospodarczej oraz zniesienie bądź zminimalizowanie barier hamujących…
Current development of CFTR potentiators in the last decade
2020
Cystic fibrosis (CF) is a genetic disorder produced by the loss of function of CFTR, a main chloride channel involved in transepithelial salt and water transport. CFTR function can be rescued by small molecules called "potentiators" which increase gating activity of CFTR on epithelial surfaces. High throughput screening (HTS) assays allowed the identification of new chemical entities endowed with potentiator properties, further improved through medicinal chemistry optimization. In this review, the most relevant classes of CFTR potentiators developed in the last decade were explored, focusing on structure-activity relationships (SAR) of the different chemical entities, as a useful tool for t…
Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons
2011
Transport of mRNAs to diverse neuronal locations via RNA granules serves an important function in regulating protein synthesis within restricted sub-cellular domains. We recently detected the Huntington's disease protein huntingtin (Htt) in dendritic RNA granules; however, the functional significance of this localization is not known. Here we report that Htt and the huntingtin-associated protein 1 (HAP1) are co-localized with the microtubule motor proteins, the KIF5A kinesin and dynein, during dendritic transport of β-actin mRNA. Live cell imaging demonstrated that β-actin mRNA is associated with Htt, HAP1, and dynein intermediate chain in cultured neurons. Reduction in the levels of Htt, H…
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation
2008
The Werner syndrome helicase/3′-exonuclease (WRN) is a major component of the DNA repair and replication machinery. To analyze whether WRN is involved in the repair of topoisomerase-induced DNA damage we utilized U2-OS cells, in which WRN is stably down-regulated (wrn-kd), and the corresponding wild-type cells (wrn-wt). We show that cells not expressing WRN are hypersensitive to the toxic effect of the topoisomerase I inhibitor topotecan, but not to the topoisomerase II inhibitor etoposide. This was shown by mass survival assays, colony formation and induction of apoptosis. Upon topotecan treatment WRN deficient cells showed enhanced DNA replication inhibition and S-phase arrest, whereas af…
Els epítets dels artistes baixmedievals al servei dels poders reial i municipal
2021
Aquest article estudia els adjectius que van rebre els artistes que treballaren per al rei i per a les elits ciutadanes en els territoris de parla catalana durant els segles XIV i XV. En particular, se n’hi examinen dos: apte i subtil. Les notícies exhumades per uns altres especialistes fins al moment permeten comprendre’ls en el propi context documental. Ací es compara el seu significat amb uns altres exemples de la literatura baixmedieval de la Corona d’Aragó i es du a terme una aproximació històrica com a paraules que al·ludien a la perícia de l’artista i que van ser escollides amb una finalitat. Participaren i repercutiren, per tant, en la relació històrica de l’artista amb el client, …
Entrepreneurial strategies of Etna wine farms
2014
Viticulture, as well as agriculture in general, performs an environmental and landscaping function and it encourages rural development through the creation of income and job opportunities in the areas where wine is produced. The wine sector, in fact, is of great social and economic importance within the Sicilian agriculture and food industry, because of the job opportunities it provides and due to Sicilian pedoclimatic peculiarities, variety of grape wines cultivars and production process. The present study aims at assessing the competitiveness of small and medium-sized enterprises that cultivate wine grapes in the Etna area. In particular, it has been examined a sample of wine farms that p…
ACKERMANS et al.
2019
One reason for the mammalian clade’s success is the evolutionary diversity of their teeth. In herbivores, this is represented by high‐crowned teeth evolved to compensate for wear caused by dietary abrasives like phytoliths and grit. Exactly how dietary abrasives wear teeth is still not understood completely. We fed four different pelleted diets of increasing abrasiveness (L: Lucerne; G: grass; GR: grass and rice husks; GRS: grass, rice husks, and sand) to four groups of a total of 28 adult goats, all with completely erupted third molars, over a six‐month period. Tooth morphology was captured by medical computed tomography scans at the beginning and end of the controlled feeding experi…