Search results for "Small"

Business Models and Market Entry Mode Choice of Small Software Firms

2007

So far the critical choice of the entry mode for a target country has been examined ignoring the special features of firms. Particularly, the impact of the wide variation of business models of software firms has been ignored. This multi-case study investigates the relation between the business model and the entry mode of eight software firms. The results imply that the product strategy and the service and implementation model of a software firm are closely connected to the entry mode choice, while the distribution model of intangible software products does not seem to have impact on the operation mode. peerReviewed

Mécanisme d’absorption intestinale des acides gras à longue chaîne : rôle émergent du CD36

2012

International audience; Excessive lipid intake, associated with a qualitative imbalance, favors the development of obesity and associated diseases. Among the organs involved in lipid homeostasis, the small intestine remains the most poorly known although it is responsible for the lipid bioavailability and largely contributes to the regulation of postprandial hypertriglyceridemia. The mechanism of long chain fatty acid (LCFA) intestinal absorption is not totally elucidated. The synthesis of recent literature indicates that the intestine is able to adapt its absorption capacity to the fat content of the diet. This adaptation takes place through a fat-coordinated induction of LBP and apolipopr…

Novel Pharmaceutical and Nutraceutical-Based Approaches for Cardiovascular Diseases Prevention Targeting Atherogenic Small Dense LDL

2022

Compelling evidence supports the causative link between increased levels of low-density lipoprotein cholesterol (LDL-C) and atherosclerotic cardiovascular disease (CVD) development. For that reason, the principal aim of primary and secondary cardiovascular prevention is to reach and sustain recommended LDL-C goals. Although there is a considerable body of evidence that shows that lowering LDL-C levels is directly associated with CVD risk reduction, recent data shows that the majority of patients across Europe cannot achieve their LDL-C targets. In attempting to address this matter, a new overarching concept of a lipid-lowering approach, comprising of even more intensive, much earlier and lo…

Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches

2013

Small, dense low density lipoprotein (sdLDL) represents an emerging cardiovascular risk factor, since these particles can be associated with cardiovascular disease (CVD) independently of established risk factors, including plasma lipids. Obese subjects frequently have atherogenic dyslipidaemia, including elevated sdLDL levels, in addition to elevated triglycerides (TG), very low density lipoprotein (VLDL) and apolipoprotein-B, as well as decreased high density lipoprotein cholesterol (HDL-C) levels. Obesity-related co-morbidities, such as metabolic syndrome (MetS) are also characterized by dyslipidaemia. Therefore, agents that favourably modulate LDL subclasses may be of clinical value in t…

Extracellular Vesicles as Biological Shuttles for Targeted Therapies.

2019

The development of effective nanosystems for drug delivery represents a key challenge for the improvement of most current anticancer therapies. Recent progress in the understanding of structure and function of extracellular vesicles (EVs)—specialized membrane-bound nanocarriers for intercellular communication—suggests that they might also serve as optimal delivery systems of therapeutics. In addition to carrying proteins, lipids, DNA and different forms of RNAs, EVs can be engineered to deliver specific bioactive molecules to target cells. Exploitation of their molecular composition and physical properties, together with improvement in bio-techniques to modify their content are critical iss…

Essays on the economics of small business finance

2013

Biology of the sauropod dinosaurs: the evolution of gigantism

2010

The herbivorous sauropod dinosaurs of the Jurassic and Cretaceous periods were the largest terrestrial animals ever, surpassing the largest herbivorous mammals by an order of magnitude in body mass. Several evolutionary lineages among Sauropoda produced giants with body masses in excess of 50 metric tonnes by conservative estimates. With body mass increase driven by the selective advantages of large body size, animal lineages will increase in body size until they reach the limit determined by the interplay of bauplan, biology, and resource availability. There is no evidence, however, that resource availability and global physicochemical parameters were different enough in the Mesozoic to ha…

Yhdenvertaisuutta, omanarvontuntoa ja yhdessä tukemista : erityisen tuen moniammatillinen ohjausmalli lukivaikeuden kysymyksiin Mynämäen lukiossa : y…

2012

TIIVISTELMÄ Ala-Krekola-Suni, Anu Yhdenvertaisuutta, omanarvontuntoa ja yhdessä tukemista. Erityisen tuen moniammatillinen ohjausmalli lukivaikeuden kysymyksiin Mynämäen lukiossa. Yksin puurtamisesta kohti vertaistukea ja moniasiantuntijuutta. Jyväskylä: Jyväskylän yliopisto. Opettajankoulutuslaitos. Ohjauksen koulutus ja tutkimus, 2012, 63 s. Ohjauksen kehittämishankkeita ja käytänteitä. Lukiolaisten ja lukioon tulevien joukko on 2000-luvun aikana heterogeenistynyt. Lukioon hakeutuu yhä suurempi joukko opiskelijoita, joilla on oppimiseen liittyviä haasteita tai pulmia. Vuonna 2005 annettu asetus ylioppilastutkinnosta huomioi erityistä tukea tarvitsevat opiskelijat, esimerkiksi lukivaikeuti…

The effects of the anti-mafia entrepreneurial behavior on firm performance: an empirical study on southern Italian small-medium enterprises

2015

The organized crime is a relevant ethical, cultural, legal, sociologic and economic issue in many countries. In the last years there have been some positive signs of a reaction against the mafia like the successful experience of Addiopizzo, an anti-bribery association founded in Palermo in 2004 that today counts over 500 affiliated firms. Gambetta (1993) suggests the mafia could better be understood as a profit maximizing corporation in the marketplace for private protection. Despite this position has been criticized (Scalia, 2010), it highlights the crucial role of the pizzo for the mafia activities. In this study, we identify as “Anti-mafia Entrepreneurial Behaviour” (AEB) the choice of t…

Prediction and interpolation of time series by state space models

2015

Artikkeliväitöskirja. Sisältää yhteenveto-osan ja neljä artikkelia. Article dissertation. Contains an introduction part and four articles. A large amount of data collected today is in the form of a time series. In order to make realistic inferences based on time series forecasts, in addition to point predictions, prediction intervals or other measures of uncertainty should be presented. Multiple sources of uncertainty are often ignored due to the complexities involved in accounting them correctly. In this dissertation, some of these problems are reviewed and some new solutions are presented. A state space approach is also advocated for an e cient and exible framework for time series forecas…