Search results for "Small"
showing 10 items of 2441 documents
Trans -Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging
2020
Tumor targeting using agents with slow pharmacokinetics represents a major challenge in nuclear imaging and targeted radionuclide therapy as they most often result in low imaging contrast and high radiation dose to healthy tissue. To address this challenge, we developed a polymer-based targeting agent that can be used for pretargeted imaging and thus separates tumor accumulation from the imaging step in time. The developed targeting agent is based on polypeptide-graft-polypeptoid polymers (PeptoBrushes) functionalized with trans-cyclooctene (TCO). The complementary In-111-labeled imaging agent is a 1,2,4,5-tetrazine derivative, which can react with aforementioned TCO-modified PeptoBrushes i…
Business models, small firms, and performance in knowledge-intensive based services. A study in the private health sector
2020
During the last years, and due to social and economic changes, the demand for private health services (PHS) is growing. A more significant number of companies appeared under different business model formulas. Besides the traditionally independent professionals, other types of entrepreneurs appeared under associated business. As a result of these changes, there are differences in how these services are provided and their performance. OBJECTIVES: This work is proposed to study the business model effect on small private health service companies' activity and analyze institutions’ and intellectual capital's role in their performance. METHODOLOGY: A qualitative-quantitative mixed method was desi…
Aspetti della produzione dei piccoli ruminanti con impatto sulla salute umana
2011
Negli ultimi anni l’attenzione del consumatore si è sempre più orientata verso le caratteristiche nutrizionali degli alimenti. Queste proprietà sono di grande importanza anche per quanto riguarda le produzioni dei piccoli ruminanti. Il presente lavoro ha lo scopo di riassumere i principali risultati emersi dal progetto di ricerca “Aspetti della produzione dei piccoli ruminanti con particolare impatto sulla salute umana”. Sono stati analizzati mediante i metodi descritti in letteratura: 1) i polimorfismi genetici dei biopeptidi del latte dei piccoli ruminanti; 2) le attività di alcuni enzimi della membrana del globulo di grasso e la frazione lipidica del latte ovino; 3) la qualità nutriziona…
Onnistuminen työelämän tiimeissä
2018
In digitalized contemporary working life virtual teams have become increasingly ubiquitous. Teams are seen as platforms for synergy, productiveness, and efficacy. However, manifold organizational environments, technological developments, and extended working possibilities—as well as conceptual, methodological, and theoretical features—make successful teams complex to outline and examine. The focus of this doctoral dissertation is in examining working-life teams’ success in the times of digitalization and communication technology expansion. The study embraces a qualitative and inductive research agenda. This dissertation comprises four articles, including one systematic literature review and…
Kokonaisarkkitehtuurin laadun ja kypsyystason yhteys
2017
Tässä opinnäytetyössä tarkastellaan, onko kokonaisarkkitehtuurin kypsyystasolla ja kokonaisarkkitehtuurituotteen laadulla keskinäistä yhteyttä. Tämän selvittämiseksi valittiin kirjallisuuslähteistä ne artikkelit, joissa kokonaisarkkitehtuurin laatua tutkitaan laatuattribuuttien (quality attributes) kautta. Näiden artikkeleiden perusteella muodostettiin kahdeksan laatuattribuuttia. Näiden laatuattribuuttien kuvauksia verrattiin kolmen kypsyysmallin (JHKA:n kypsyystasomalli, EAMM, DyAMM) kypsyystasokuvauksiin. Näin haluttiin selvittää, kuuluvatko laatuattribuutit tietyille kypsyystasoille. Tämän tarkastelun perusteella näyttää siltä, että kokonaisarkkitehtuurituotteen laadulla ja kypsyystasol…
Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…
2006
Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…
Increased plasma resistin concentrations are associated with atherogenic small, dense low-density lipoproteins in patients with type-2 diabetes
2010
Inhibition of small G proteins of the Rho family by statins orClostridium difficiletoxin B enhances cytokine-mediated induction of NO synthase II
2000
In order to investigate the involvement of Ras and/or Rho proteins in the induction of the inducible isoform of nitric oxide synthase (NOS II) we used HMG-CoA reductase inhibitors (statins) and Clostridium difficile toxin B (TcdB) as pharmacological tools. Statins indirectly inhibit small G proteins by preventing their essential farnesylation (Ras) and/or geranylgeranylation (Rho). In contrast, TcdB is a glucosyltransferase and inactivates Rho-proteins directly. Human A549/8- and DLD-1 cells as well as murine 3T3 fibroblasts were preincubated for 18 h with statins (1–100 μM) or TcdB (0.01–10 ng ml−1). Then NOS II expression was induced by cytokines. NOS II mRNA was measured after 4–8 h by R…
Quantificazione del merito creditizio e costo del denaro per le imprese italiane: caratteristiche e simulazioni spaziali in Italia
2012
L’economia dei flussi di cassa è il Leitmotiv di questi anni, e il denaro condiziona i comportamenti individuali e collettivi. Economie tradizionalmente solide entrano in crisi se non riscuotono la fiducia dei mercati, e le famiglie, come le imprese, difficilmente riescono a programmare il proprio futuro senza le risorse finanziarie occorrenti per le proprie attività. Nel complesso periodo che stiamo vivendo, è opinione diffusa che l’uscita dalla crisi economica derivi da cambiamenti epocali nell’organizzazione dei sistemi produttivi e finanziari nonché negli stili di vita, rivisitando il significato stesso di sviluppo economico. In tale contesto la marginalità finanziaria, intesa come vant…
MbCo in Saccharide Solid Amorphous Systems: A Combined FTIR and SAXS Study
2011
Saccharides, and in particular trehalose, are known for their efficiency in protecting biostructures against environmental stress [1], although the preservation mechanism is still debated. Experiments and simulations [2,3] on carboxy-myoglobin (MbCO) showed that the protein dynamics is highly inhibited in dry trehalose matrices, the inhibition being dependent on the water content. In these conditions, a mutual protein-matrix structural and dynamic influence is observed.Here we report a combined FTIR and SAXS study on MbCO embedded in dry amorphous matrices of trehalose and sucrose. FTIR measurements were performed at different protein/sugar ratios, focussing on the stretching band of the bo…