Search results for "Small"
showing 10 items of 2441 documents
On overall sampling plan for small area estimation
2017
The time and budget restrictions in survey sampling can impose limits on the area sample sizes. This may reduce the possibility to obtain area-specific and population parameters estimates with adequate precision. Market research companies and institutes for producing official statistics face frequently this problem. Various models and methods for small area estimation (SAE) have been developed to solve this problem. The sample allocation must support the selected model and method to ensure efficient estimation and must be implemented in the design phase of the survey. The proposed allocation is developed by incorporating auxiliary information, a model, and an estimation method. The estimate…
Assessment of actual transpiration rate in olive tree field combining sap-flow, leaf area index and scintillometer measurements
2009
Kuldīgas pilsētas sarukšanas tendences un stratēģiskie risinājumi
2018
Pilsētu sarukšana un stratēģiskie risinājumi ir plaši izpētīti lielajās pilsētās, bet ir ļoti maz pētījumu, kā šis process izpaužas un ietekmē mazās pilsētas (ar iedzīvotāju skaitu līdz 25 000), kurām pieder arī Kuldīga. Kopš 1999.gada iedzīvotāju skaits Kuldīgā ir samazinājies par 18,6% jeb 2449 iedzīvotājiem. Līdz ar to par darba mērķi tika izvirzīts izstrādāt priekšlikumus Kuldīgas pilsētai, balstoties uz līdzšinējiem sociālekonomiskajiem procesiem un labās prakses piemēriem Eiropā un citviet pasaulē. Pētījuma ietvaros tika analizēta sarūkošo pilsētu stratēģisko risinājumu pieredze, sekundārie dati, kā arī tika veikta trīs spēkā esošo Kuldīgas novada teritorijas attīstības plānošanas dok…
Ohjelmistokehityksen muutos ja sen vaikutus ohjelmistoprojektin johtamiseen
2015
Tutkielman tarkoituksena oli selvittää, miten ja miksi ohjelmistokehittäminen on muuttunut viimeisen 10 vuoden aikana ja etenkin, kuinka tämä muutos on vaikuttanut ohjelmistokehitysprojektien johtamiseen. Aihetta lähestyttiin perinteisen ohjelmistokehittämisen vesiputousmallin ja ketterän kehittämisen scrum- menetelmän kautta. Esimerkkinä toimivista menetelmistä käytiin läpi perusteet toimintatavoista sekä johtamisesta. Kun menetelmiin oli tutustuttu, siirryttiin haasteisiin, joita yrityksissä kohdattiin perinteisestä ketterään kehitykseen siirryttäessä. Tämän jälkeen syvennyttiin vielä hieman tarkemmin johtamiseen liittyviin haasteisiin ja ominaisuuksiin, joita hyv…
Ajatteluriskit organisaatiomuutoksessa
2003
Polymeric nanoparticles for siRNA delivery: Production and applications
2017
Gene therapy through the use of siRNA and a polymeric carrier are becoming an efficient therapeutic option to conventional pharmaceutical formulations for the treatment of deadly diseases, such as cancer, pulmonary, ocular and neurodegenerative diseases. However, several considerations regarding the stability, formulation, and efficacy have to be faced up until these systems could be considered to be a marketable pharmaceutical products for to extend siRNA application to clinical practice. This review is focused on the key challenges of siRNA therapeutics, with special attention on the faced obstacles and on the formulation-related difficulties, providing a list of requirements needed for o…
Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.
2021
Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…
The small protein TrpM is involved in Streptomyces coelicolor differentiation
STARTUP, INNOVAZIONE E SOCIETA' AGRICOLE
2020
The work aims to identify advantageous solutions for agricultural companies that want to adhere to the discipline provided by the legislator for SMEs by comparing it with the discipline provided for Startups