Search results for "Small"
showing 10 items of 2441 documents
Dasymetric distribution of votes in a dense city
2017
[EN] A large proportion of electoral analyses using geography are performed on a small area basis, such as polling units. Unfortunately, polling units are frequently redrawn, provoking breaks in their data series. Previous electoral results play a key role in many analyses. They are used by political party workers and journalists to present quick assessments of outcomes, by political scientists and electoral geographers to perform detailed scrutinizes and by pollsters and forecasters to anticipate electoral results. In this paper, we study to what extent more complex geographical approaches (based on a proper location of electors on the territory using dasymetric techniques) are of value in…
User-cell association in heterogenous small cell networks: A context-aware approach
2015
Deploying small cells to complement the traditional cellular networks is foreseen as a major feature of the next generation of wireless networks. In this paper, a novel approach for addressing the cell association problem in heterogenous small cell networks is proposed. The presented approach exploits different types of information extracted from the user devices and environment to improve the way in which users are assigned to their serving small cell base stations (SBSs). We formulate the problem within the framework of matching theory, where the players, namely the users and SBSs, have interdependent preferences over the members of the opposite set. We also utilize the fuzzy synthetic ev…
Adaptive energy management strategy for sustainable voltage control of PV-hydro-battery integrated DC microgrid
2021
Abstract DC microgrid has relatively more advantages of power quality, not requirement of reactive power, higher operational efficiency compare to AC microgrid. DC microgrid can facilitate effective integration of distributed clean energy resources and efficient solution for providing electricity to remote areas (e.g. North Eastern States of India). Recently, India has commissioned small hydro, solar PV and battery storage integrated DC microgrids (MGs) to meet the locally increasing load demand of northeastern states. The sudden change in solar insolation during the load power dynamics can cause unbalanced power flow in such isolated MGs. Due to the slow response time of small hydro power …
Deine Sonia: A Reading from a Burned Letter by Reinhard Bölling, Translated by D. E. Rowe
2018
It was in January 1990. Finally, just two months after the Berlin Wall had fallen, I had the opportunity to spend a few days at the Mittag-Leffler Institute in Djursholm, a small town just northeast of Stockholm. The palatial villa that today houses the Institute is the former home of Gosta Mittag-Leffler (1846–1927), and on entering its doorway I felt as if I had taken a step back into the world in which he lived. For me, the Institute’s single greatest attraction lay in its archival holdings, and particularly the extensive correspondence that linked Mittag-Leffler with many of the era’s leading mathematicians. A former student of Karl Weierstrass (1815–1897), Mittag-Leffler sought to pres…
Verso una dimensione narrativa delle mappe
2021
Tra il pensiero e la costruzione dell’architettura il disegno ha un ruolo baricentrico per connettere i diversi protagonisti di una realizzazione e per coinvolgere la collettività facendo percepire inedite prospettive. La scrittura si rivela utile per esplicitare ciò che nella grafica è sotteso e per stabilire un ordine nuovo nel ragionamento progettuale. I rapporti fra segni e significati si moltiplicano nei sistemi informativi recenti in cui si ha la sensazione di poter dire moltissimo (dati numerici e spaziali) ma a volte sfugge quella sintesi indispensabile per una interpretazione concreta, finalizzata alla costruzione di possibili esperienze fisiche. Per l’esplorazione dell’uso di dive…
Choosing Optimal Seed Nodes in Competitive Contagion.
2019
International audience; In recent years there has been a growing interest in simulating competitive markets to find out the efficient ways to advertise a product or spread an ideology. Along this line, we consider a binary competitive contagion process where two infections, A and B, interact with each other and diffuse simultaneously in a network. We investigate which is the best centrality measure to find out the seed nodes a company should adopt in the presence of rivals so that it can maximize its influence. These nodes can be used as the initial spreaders or advertisers by firms when two firms compete with each other. Each node is assigned a price tag to become an initial advertiser whi…
De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments.
2013
Protein kinases constitute an attractive family of enzyme targets with high relevance to cell and disease biology. Small molecule inhibitors are powerful tools to dissect and elucidate the function of kinases in chemical biology research and to serve as potential starting points for drug discovery. However, the discovery and development of novel inhibitors remains challenging. Here, we describe a structure-based de novo design approach that generates novel, hinge-binding fragments that are synthetically feasible and can be elaborated to small molecule libraries. Starting from commercially available compounds, core fragments were extracted, filtered for pharmacophoric properties compatible w…
Recent advances in smart biotechnology: Hydrogels and nanocarriers for tailored bioactive molecules depot
2017
Over the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biotechnology offers considerable advantages compared to traditional therapeutic approaches, such as reducing side effects, specific treatments, higher patient compliance and therefore more effective treatments leading to lower healthcare costs. Within this sector, smart nanotechnology and colloidal self-assembling systems represent pivotal tools able to modulate the delivery of therapeutics. A comprehens…
Enzyme and lateral flow monoclonal antibody-based immunoassays to simultaneously determine spirotetramat and spirotetramat-enol in foodstuffs.
2021
Spirotetramat is employed worldwide to fight insect pests due to its high efficiency. This chemical is quickly metabolized by plants into spirotetramat-enol, so current regulations establish that both compounds must be determined in foodstuffs for monitoring purposes. Nowadays, immunochemical methods constitute rapid and cost-effective strategies for chemical contaminant analysis at trace levels. However, high-affinity binders and suitable bioconjugates are required. In this study, haptens with opposite functionalisation sites were synthesized in order to generate high-affinity monoclonal antibodies. A direct competitive enzyme-linked immunosorbent assay with an IC50 value for the sum of sp…
Development of Polyamine‐Substituted Triphenylamine Ligands with High Affinity and Selectivity for G‐Quadruplex DNA
2019
Currently, significant efforts are devoted to designing small molecules able to bind selectively to guanine quadruplexes (G4s). These noncanonical DNA structures are implicated in various important biological processes and have been identified as potential targets for drug development. Previously, a series of triphenylamine (TPA)-based compounds, including macrocyclic polyamines, that displayed high affinity towards G4 DNA were reported. Following this initial work, herein a series of second-generation compounds, in which the central TPA has been functionalised with flexible and adaptive linear polyamines, are presented with the aim of maximising the selectivity towards G4 DNA. The acid-bas…