6533b838fe1ef96bd12a5191

RESEARCH PRODUCT

Recent advances in smart biotechnology: Hydrogels and nanocarriers for tailored bioactive molecules depot

Filipe E. AntunesAna C. FonsecaBarbara DapasPaolo MarizzaBruno MedronhoGesmi MilcovichSilvia GiordaniFrancesca PerroneGabriele GrassiStefania LettieriJorge F. J. CoelhoRossella FarraMario Grassi

subject

Bioactive molecules02 engineering and technologyHepatocellular-carcinoma cells01 natural sciencesMiceColloid and Surface ChemistryDrug Delivery SystemsCarbon nano materialNanotechnologyMolecular Targeted TherapyTransgenesRNA Small InterferingPatient complianceTransfer radical polymerizationMicro/nanocarrierMedical treatmentMicro/nanocarriersBioactive molecule deliveryHydrogelsSurfaces and Interfaces021001 nanoscience & nanotechnologyLiposomeBiopharmaceuticalOral deliverySelf-healing hydrogelsIntercellular Signaling Peptides and Proteins0210 nano-technologyAssembling peptide hydrogelsSurfaces and InterfaceNucleic-acid deliveryPlasmidsDiagnostic ImagingSolid lipid nanoparticlesNanotechnology010402 general chemistryAntibodiesSmall Molecule LibrariesCarbon nano-onionsIn-vivoAnimalsHumansPhysical and Theoretical Chemistrybusiness.industryDrug-delivery0104 chemical sciencesBiotechnologyHydrogelSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoMolecular ProbesBioactive molecule delivery; Carbon nano materials; Hydrogels; Liposomes; Micro/nanocarriers; Surfaces and Interfaces; Physical and Theoretical Chemistry; Colloid and Surface ChemistryLiposomesNonviral gene deliveryCarbon nano materialsNanoparticlesBusinessNanocarriers

description

Over the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biotechnology offers considerable advantages compared to traditional therapeutic approaches, such as reducing side effects, specific treatments, higher patient compliance and therefore more effective treatments leading to lower healthcare costs. Within this sector, smart nanotechnology and colloidal self-assembling systems represent pivotal tools able to modulate the delivery of therapeutics. A comprehensive understanding of the processes involved in the self assembly of the colloidal structures discussed therein is essential for the development of relevant biomedical applications. In this review we report the most promising and best performing platforms for specific classes of bioactive molecules and related target, spanning from siRNAs, gene/plasmids, proteins/growth factors, small synthetic therapeutics and bioimaging probes. Istituto Italiano di Tecnologia (IIT) COST Action [CA 15107] People Program (Marie Curie Actions) of the European Union's Seventh Framework Program under REA [606713 BIBAFOODS] Portuguese Foundation for Science and Technology (FCT) [PTDC/AGR-TEC/4814/2014, IF/01005/2014] Fundacao para a Ciencia e Tecnologia [SFRH/BPD/99982/2014] Danish National Research Foundation [DNRF 122] Villum Foundation [9301] Italian Ministry of Instruction, University and Research (MIUR), PRIN [20109PLMH2] "Fondazione Beneficentia Stiftung" Vaduz Fondo di Ateneo FRA FRA info:eu-repo/semantics/publishedVersion

yearjournalcountryeditionlanguage
2017-11-01
10.1016/j.cis.2017.05.009https://hdl.handle.net/10400.1/12931