Search results for "Smooth"

Blind Robust 3-D Mesh Watermarking Based on Mesh Saliency and QIM Quantization for Copyright Protection

2019

International audience; Due to the recent demand of 3-D models in several applications like medical imaging, video games, among others, the necessity of implementing 3-D mesh watermarking schemes aiming to protect copyright has increased considerably. The majority of robust 3-D watermark-ing techniques have essentially focused on the robustness against attacks while the imperceptibility of these techniques is still a real issue. In this context, a blind robust 3-D mesh watermarking method based on mesh saliency and Quantization Index Modulation (QIM) for Copyright protection is proposed. The watermark is embedded by quantifying the vertex norms of the 3-D mesh using QIM scheme since it offe…

Multifibrillar bundles of a self-assembling hyaluronic acid derivative obtained through a microfluidic technique for aortic smooth muscle cell orient…

2018

A hyaluronic acid derivative that is able to physically crosslink in a saline aqueous environment was employed for the production of fibers with a mean diameter of 50 μm using a microfluidic technique. The microfibers were collected in a tailored rotating collector and assembled to form multifibrillar bundles. The orientation of the microfibers on the collected bundles was evaluated by microCT analysis. The bundles were biofunctionalized by physical addition of fibronectin or chemical tethering of a cyRGDC peptide to achieve control of Aortic Smooth Muscle Cell (AoSMC) attachment, elongation and alignment. The mechanical performances of these bundles were evaluated by elongation tests, rela…

Uncoupling of Endothelial Nitric Oxide Synthase in Cardiovascular Disease and its Pharmacological Reversal

2010

Publisher Summary This chapter discusses the role of oxidative stress in vascular dysfunction and atherogenesis, and strategies for its prevention. Endothelial dysfunction and oxidative stress have been identified as a common denominator of many cardiovascular risk factors. They support pro-inflammatory, prothrombotic, proliferative, and vasoconstrictor mechanisms that are involved in the initiation, progression, and complications of atherosclerosis. The pathophysiologic causes of oxidative stress involve changes in a number of different enzyme systems. Increased production of ROS by uncoupled eNOS is likely to contribute significantly to vascular oxidative stress and endothelial dysfunctio…

The hedgehog receptor patched is involved in cholesterol transport.

2011

International audience; BACKGROUND: Sonic hedgehog (Shh) signaling plays a crucial role in growth and patterning during embryonic development, and also in stem cell maintenance and tissue regeneration in adults. Aberrant Shh pathway activation is involved in the development of many tumors, and one of the most affected Shh signaling steps found in these tumors is the regulation of the signaling receptor Smoothened by the Shh receptor Patched. In the present work, we investigated Patched activity and the mechanism by which Patched inhibits Smoothened. METHODOLOGY/PRINCIPAL FINDINGS: Using the well-known Shh-responding cell line of mouse fibroblasts NIH 3T3, we first observed that enhancement …

Pauls rectifiable and purely Pauls unrectifiable smooth hypersurfaces

2020

This paper is related to the problem of finding a good notion of rectifiability in sub-Riemannian geometry. In particular, we study which kind of results can be expected for smooth hypersurfaces in Carnot groups. Our main contribution will be a consequence of the following result: there exists a -hypersurface without characteristic points that has uncountably many pairwise non-isomorphic tangent groups on every positive-measure subset. The example is found in a Carnot group of topological dimension 8, it has Hausdorff dimension 12 and so we use on it the Hausdorff measure . As a consequence, we show that any Lipschitz map defined on a subset of a Carnot group of Hausdorff dimension 12, with…

Towards an efficient meshfree solver

2016

In this paper we focus on the enhancement in accuracy approximating a function and its derivatives via smoothed particle hydrodynamics. We discuss about improvements in the solution by reformulating the original method by means of the Taylor series expansion and by projecting with the kernel function and its derivatives. The accuracy of a function and its derivatives, up to a fixed order, can be simultaneously improved by assuming them as unknowns of a linear system. The improved formulation has been assessed with gridded and scattered data points distribution and the convergence has been analyzed referring to a case study in a 2D domain.

Computational Techniques for the Analysis of Small Signals in High-Statistics Neutrino Oscillation Experiments

2020

The current and upcoming generation of Very Large Volume Neutrino Telescopes – collecting unprecedented quantities of neutrino events – can be used to explore subtle effects in oscillation physics, such as (but not restricted to) the neutrino mass ordering. The sensitivity of an experiment to these effects can be estimated from Monte Carlo simulations. With the high number of events that will be collected, there is a trade-off between the computational expense of running such simulations and the inherent statistical uncertainty in the determined values. In such a scenario, it becomes impractical to produce and use adequately-sized sets of simulated events with traditional methods, such as M…

Commentaries on Viewpoint: Airway smooth muscle and airway hyperresponsiveness in human asthma: have we chased the wrong horse?

2014

Tenascin gene expression in rat liver and in rat liver cells. In vivo and in vitro studies.

1991

Tenascin is a major glycoprotein constituent of the extracellular matrix with a strong affinity to fibronectin; its distribution is believed to be temporarily and spatially limited. Tenascin gene expression is increased during wound healing processes. As repair mechanisms in chronic liver diseases resemble wound healing we studied tenascin gene expression in rat liver and in isolated rat liver cells. In normal rat liver a tenascin specific antiserum stains sinusoidal cells with fiber-like prolongations, which at the same time are desmin-positive (ITO-cells). In the CCl4-acutely-damaged liver a strong tenascin staining is detected in cells located among the mononuclear cells of the inflammat…

Relaxation induced by N-terminal fragments of chromogranin A in mouse gastric preparations.

2007

Abstract A definitive role for chromogranin A (CGA)-derived fragments in the control of the gastrointestinal smooth muscle contractility has not been yet established. The purpose of the present study was to evaluate, in vitro , the effects of the recombinant vasostatin 1–78 (VS-1), CGA 7–57 and CGA 47–66 on the mouse gastric mechanical activity, recording the changes of intraluminal pressure. VS-1, CGA 7–57 and CGA 47–66 produced concentration-dependent relaxations. Mouse anti-vasostatin-1 monoclonal antibody 5A8, recognising the region 53–57, abolished the relaxation induced by VS-1, indicating the specificity of the effect. The relaxation was significantly reduced by tetrodotoxin (TTX), b…