Search results for "Smut"
showing 10 items of 493 documents
Intrinsic superoxide dismutase activity of MnO nanoparticles enhances the magnetic resonance imaging contrast
2020
Superoxide radicals are associated with the development of many severe diseases, such as cancer. Under nonpathogenic conditions, the natural enzyme superoxide dismutase (SOD) regulates the intracellular superoxide concentrations, but nearly all tumor tissues show reduced SOD levels. Selective imaging in early progression stages remains a key requirement for efficient cancer diagnosis and treatment. Magnetic resonance imaging (MRI) as a noninvasive tool with high spatial resolution may offer advantages here, but MRI contrast agents exhibiting a redox-triggered change in the image contrast towards superoxide radicals have not been reported so far. Here we show that manganese oxide (MnO) nanop…
Manganese(II) complexes of scorpiand-like azamacrocycles as MnSOD mimics.
2011
Mn(II) complexes of scorpiand-type azamacrocycles constituted by a tretrazapyridinophane core appended with an ethylamino tail including 2- or 4-quinoline functionalities show very appealing in vitro SOD activity. The observed behaviour is related to structural and electrochemical parameters.
Bismuta selenīda plāno kārtiņu elektroķīmisko īpašību raksturošana nātrija nitrāta ūdens elektrolītā
2021
Bakalaura darba ietvaros tika veikti elektroķīmiskie mērījumi bismuta slelenīda plānajām kārtiņām, izmantojot ciklisko voltamperometriju (CV) un elektroķīmisko impedances spektroskopiju (EIS), kā arī plāno kārtiņu raksturojums, izmantojot skenējošo elektronu mikroskopiju (SEM) un enerģijas dispersīvo rentgenstaru spektroskopiju (EDX). Iegūtie rezultāti statistiski apstrādāti, salīdzināti ar literatūru un izdarīti secinājumi par bismuta selenīdu veikstpēju nātrija nitrāta ūdens elektrolītā. Pētījuma rezultāti norāda uz Bi2Se3 plāno kārtiņu perspektīvu pielietojumu kā anoda elektrodu nātrija jonu baterijās ar ūdens elektrolītu (ASIB).
Piecpadsmitās grupas metālu halkogenīdu plāno kārtiņu sintēze, fizikālo īpašību raksturojums un pielietojums termoelektriskās ierīcēs
2019
Termoelektriskie ģeneratori ir ierīces, kuras, pastāvot temperatūras gradientam, spēj ražot elektrisko strāvu. Jeb vienkāršiem vārdiem sakot, šīs ierīces siltumu pārvērš elektrībā. Tas ir ērts veids, kā nelietderīgi radušos siltumu jebkuros citos procesos pārveidot vēlamā elektriskajā enerģijā. Taču mūsdienās šādas ietaises ir reti sastopamas to zemās lietderības un citu faktoru dēļ. Termoelektriskie ģeneratori visbiežāk sastāv no atsevišķu n un p tipa pusvadītāju elementu dažādiem slēgumiem, lai pēc nepieciešamības palielinātu izejas strāvu un spriegumu. Šajā gadījumā tiek apskatīts n tipa bismuta selenīda un p tipa antimona telurīda virknes slēgums dažādās konfigurācijās attiecībā pret te…
Exercise and Metformin Intervention Prevents Lipotoxicity-Induced Hepatocyte Apoptosis by Alleviating Oxidative and ER Stress and Activating the AMPK…
2022
Objective. Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) commonly coexist and act synergistically to drive adverse clinical outcomes. This study is aimed at investigating the effects of exercise intervention and oral hypoglycaemic drug of metformin (MET) alone or combined on hepatic lipid accumulation. To investigate if oxidative stress and endoplasmic reticulum stress (ERS) are involved in lipotoxicity-induced hepatocyte apoptosis in diabetic mice and whether exercise and/or MET alleviated oxidative stress or ERS-apoptosis by AMPK-Nrf2-HO-1 signaling pathway. Methods. Forty db/db mice with diabetes ( random blood glucose ≥ 250 mg / dL ) were randomly allocated i…
Postnatal overfeeding in rats leads to moderate overweight and to cardiometabolic and oxidative alterations in adulthood.
2011
In contrast to the masses of data on obesity, few data are available concerning the cardiometabolic and oxidative consequences of moderate overweight. The model of postnatal overfeeding (OF) induces an increase in body weight at weaning that remains during adult life. Litters of Wistar rats were either maintained at 12 pups (normal-fed group, NF), or reduced to 3 pups at birth in order to induce OF. At 6 months of age, metabolic parameters, circulating oxidative stress and aortic and coronary vasoreactivity were assessed. Cardiac susceptibility to ischemia-reperfusion injury was also evaluated ex vivo as were markers of cardiac remodeling. OF led to an increase in body weight at weaning (+5…
Antioxidant treatment for impaired hypoxic ventilatory responses in experimental diabetes in the rat
2018
Inflammation, tissue hypoxia, and impaired hypoxic ventilatory response (HVR) are the intricately entwined features of diabetes which perpetuate the disease and its sequelae. Hyperglycemia, notably, is an oxygen consuming process due to enhanced cellular metabolism. Oxidative stress underlies diabetic pathogenesis and also is a crucial modulator of the hypoxic chemoreflex. The present study seeks to determine if suppressed ventilation in diabetes could be improved by antioxidant treatment. The study was performed in streptozotocin-induced diabetes in awake rats. Two weeks into full-fledged diabetes, the rats were divided into mangiferin (potent natural antioxidant)-treated and untreated, wi…
Timing of Exercise Affects Glycemic Control in Type 2 Diabetes Patients Treated with Metformin
2018
Objective. The purpose of the study was to examine the acute effects of the timing of exercise on the glycemic control during and after exercise in T2D. Methods. This study included 26 T2D patients (14 women and 12 men) who were treated with metformin. All patients were tested on four occasions: metformin administration alone (Metf), high-intensity interval training (HIIT) performed at 30 minutes (EX30), 60 minutes (EX60), and 90 minutes (EX90) postbreakfast, respectively. Glucose, insulin, and superoxide dismutase (SOD) activity were examined. Results. Glucose decreased significantly after the exercise in EX30, EX60, and EX90. Compared with Metf, the decline in glucose immediately after th…
Fructose-enriched diet modifies antioxidant status and lipid metabolism in spontaneously hypertensive rats
2005
Abstract Objective High-fructose consumption in industrial countries has been shown to induce metabolic abnormalities or syndrome X. Changes in antioxidant defense are unknown in hypertension associated with metabolic disorders induced by high-fructose feeding. Methods Twenty spontaneously hypertensive rats were assigned to one of two groups; one received a fructose-enriched diet (60% fructose) and the other a starch diet. After a 13-wk diet period, total antioxidant status was assessed in the blood and liver by monitoring the rate of free radical-induced red blood cell hemolysis. Antioxidants (enzymes and vitamins) were determined in blood and liver. Gene expression of antioxidant enzymes …
Facilitation of Insulin Effects by Ranolazine in Astrocytes in Primary Culture
2022
Ranolazine (Rn) is a drug used to treat persistent chronic coronary ischemia. It has also been shown to have therapeutic benefits on the central nervous system and an anti-diabetic effect by lowering blood glucose levels and however, no effects of Rn on cellular sensitivity to insulin (Ins) have been demonstrated yet. The present study aimed to investigate the permissive effects of Rn on the actions of Ins in astrocytes in primary culture. Ins at 10-8 M, Rn (10-6 M) and Ins+Rn (10-8 M and 10−6 M respectively) were added to astrocytes during 24 h. In comparison to control cells, Rn and/or Ins caused modifications in cell viability and proliferation. p-AKT, p-ERK, p-eNOS, Mn-SOD, COX-2, and t…