Search results for "Sn"
showing 10 items of 3585 documents
Mindfulness, acceptance and value-based intervention for burnout : mediational roles of learning the elements of the intervention on outcomes
2015
The effects of mindfulness-based interventions and ACT on mindfulness and well-being have received a lot of interest, and their mechanisms of change have been studied recently, but still some mechanisms are missing the research attention. The mechanisms of the change that happens during an intervention with people who suffer from work related burnout, have been examined by only a couple of studies. The present study aimed to investigate these mechanisms by looking at the mediating effects of learning mindfulness, acceptance and value-based working (MAV) skills which were measured with a novel Learning Questionnaire developed for the present research project. The data of the present study wa…
Estimating the size of the loan sharking market in Italy
2014
In the current economic crisis, the risk is so high that entrepreneurs, commercial activities and even families may turn to the illegal market to obtain liquidity. This article proposes an estimate of the size of the usury credit market in Italy. The estimate is based on the assumption, provided by Guiso1, that before coming to a moneylender the borrower seeks to obtain credit through official channels. The results of our estimates confirm the seriousness of the problem, but provide much lower data than those reported periodically by the media. It is estimated that 372,000 economic activities may have been potentially involved in the usury market in 2012. The volume of loans disbursed in th…
Tiesnešu atsevišķās domas kā tiesību palīgavots. Augstākās tiesas Administratīvo lietu departamenta pieredze (2014.-2017.)
2018
Bakalaura darba tēmas nosaukums ir „Tiesnešu atsevišķās domas kā tiesību palīgavots. Augstākās tiesas Administratīvo lietu departamenta pieredze (2014.-2017.) ”. Tā kā tiesnešu atsevišķās domas nav bieži sastopamas, šī darba mērķis ir noskaidrot kādu ietekmi sniedz tiesneša atsevišķo domu institūts. Lai to noskaidrotu, darba autore analizē tiesību zinātnieku dažādos viedokļus par tiesnešu atsevišķo domu institūta esību. Autore klasificē tiesneša atsevišķo domu iedalījuma kritērijus un aplūko tiesnesim piešķirtās brīvības, vārda brīvību un neatkarību, tiesneša atsevišķo domu izpratnē. Salīdzinošā nolūkā tiek apskatīts ne tikai Latvijas, bet arī citu valstu normatīvais regulējums. Darba autor…
Anti-glomerular basement membrane antibody-mediated glomerulonephritis due to glue sniffing
1987
A 16-year-old girl developed rapidly progressive glomerulonephritis and renal failure. The disease was associated with high titres of antiglomerular basement membrane antibodies in serum, linear deposits of immunoglobulin G and diffuse epithelial crescents on renal biopsy. Past history revealed heavy smoking and deliberate sniffing of Pattex glue, a mixture of hydrocarbons which possibly may affect the structure of glomerular basement membrane. After treatment by repeated plasmapheresis and drug immunosuppression autoantibodies disappeared from serum but renal function was not influenced. Renal damage is a potential hazard for glue sniffing adolescents.
Congenital undifferentiated sarcoma associated to BCOR-CCNB3 gene fusion
2017
Small round cell sarcomas are aggressive bone and soft tissue tumors that predominantly affect children and young adults. A new group of sarcomas with a recurrent BCOR-CCNB3 gene fusion has been recently identified in previously unclassifiable small round cell sarcomas. BCOR-CCNB3 sarcomas share clinical and pathologic similarities with Ewing sarcoma, but show a stronger male predilection and less aggressiveness, as well as distinct gene expression profiling and pangenomic SNP array analyses. We report the unusual case of a congenital BCOR-CCNB3 retroperitoneal sarcoma in a female born at 34th gestational week, which was diagnosed in necropsy after 21hours of life. Immunohistochemical analy…
Validation of the SNACOR clinical scoring system after transarterial chemoembolisation in patients with hepatocellular carcinoma
2017
Abstract Background Transarterial chemoembolisation is the standard of care for intermediate stage (BCLC B) hepatocellular carcinoma, but it is challenging to decide when to repeat or stop treatment. Here we performed the first external validation of the SNACOR (tumour Size and Number, baseline Alpha-fetoprotein, Child-Pugh and Objective radiological Response) risk prediction model. Methods A total of 1030 patients with hepatocellular carcinoma underwent transarterial chemoembolisation at our tertiary referral centre from January 2000 to December 2016. We determined the following variables that were needed to calculate the SNACOR at baseline: tumour size and number, alpha-fetoprotein level,…
A Successful Aging Model Based on Personal Resources, Self-Care, and Life Satisfaction
2021
The most internationally studied models of successful aging defend that there are several pillars for a good aging: absence of disease, good cognitive and physical function, a high commitment and social activity, social capital, personal resources, life satisfaction, and spirituality. This study examines the relationships between personal resources, perceived social support, hope, spirituality, self-care and subjective well-being variables, as bases for a successful aging. One thousand and sixteen community-dwelling Spanish adults, aged 55-92 years, participated in the study. Information on variables assessed was collected using self-reported questionnaires. Confirmatory Factor Analyses and…
SHIP2: A “NEW” Insulin Pathway Target for Aging Research
2014
Strong evidence suggests that systemic inflammation and central adiposity contribute to and perpetuate metabolic syndrome. All of these alterations predispose individuals to type 2 diabetes mellitus (T2DM), cardiovascular disease, as well as Alzheimer's disease (AD), all characterized by chronic inflammatory status. On the other hand, extensive abnormalities in insulin and insulin-like growth factor I (IGF-I) and IGF-II signaling mechanisms in brains with AD have been demonstrated, suggesting that AD could be a third form of diabetes. The Src homology domain-containing inositol 5-phosphatase 2 (SHIP2) has an important role in the insulin pathway because its over-expression causes impairment…
Orosensory detection of bitter in fat-taster healthy and obese participants: Genetic polymorphism of CD36 and TAS2R38
2017
In Press, Corrected Proof — Note to users; International audience; Background & aimsWe assessed orosensory detection of a long-chain fatty acid, linoleic acid (LA), and a bitter taste marker, 6-n-propylthiouracil (PROP), and correlated lipid-taster subjects with PROP detection and polymorphism in genes encoding bitter and lipid taste receptors, respectively, TAS2R38 and CD36, in normal weight and obese subjects.DesignThe normal weight (n = 52, age = 35.3 ± 4.10 years, BMI = 23.22 ± 1.44 kg/m2) and obese (n = 52, age = 35.0 ± 5.43 years, BMI = 34.29 ± 5.31 kg/m2) participants were recruited to determine fat and bitter detection thresholds. The genomic DNA was used to determine single nucleot…
The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women.
2015
Recent studies have suggested that excessive intake of dietary fat is associated with obesity. Some obese subjects have been reported to exhibit high thresholds for the gustatory detection of lipids via lipid receptors, such as cluster of differentiation 36 (CD36). We studied lingual detection thresholds for emulsions containing oleic acid in obese Tunisian women (n203) using a three-alternative forced choice (3-AFC) method. Genotyping of theTNF-α(rs1800629),IL-6(rs1800795) andCD36(rs1761667) genes was performed to associate with lipid taste perception thresholds. TheCD36genotype distribution was as follows: GG (n42), AG (n102) and AA (n59). Women with theCD36GG genotype exhibited oral dete…