Search results for "SoMe"

showing 10 items of 5114 documents

Experimental study of isomeric intruder ½+ states 197,203At

2017

A newly observed isomeric intruder ½ + state [ T ½ = 3.5 ( 6 ) ms ] is identified in 203 At using a gas-filled recoil separator and fusion-evaporation reactions. The isomer is depopulated through a cascade of E 3 and mixed M 1 / E 2 transitions to the 9 / 2 − ground state, and it is suggested to originate from the π ( s ½ ) − 1 configuration. In addition, the structures above the ½ + state in 203 At and 197 At are studied using in-beam γ -ray spectroscopy, recoil-decay tagging, and recoil-isomer decay tagging methods. The ½ + state is fed from 3 / 2 + and 5 / 2 + states, and the origin of these states are discussed. peerReviewed

astatiiniisomersintruder states
researchProduct

Asymmetric Organocatalytic Wittig [2,3]-Rearrangement of Oxindoles

2016

A highly enantioselective organocatalytic [2,3]-rearrangement of oxindole derivatives is presented. The reaction was catalyzed by squaramide, and this provides access to 3-hydroxy 3-substituted oxindoles in high enantiomeric purities.

asymmetric organocatalytic wittigIndolesStereoisomerism010402 general chemistry01 natural sciencesBiochemistryCatalysisCatalysischemistry.chemical_compoundCombinatorial Chemistry TechniquesOrganic chemistryOxindolePhysical and Theoretical Chemistryta116Molecular Structure010405 organic chemistryOrganic ChemistrySquaramideEnantioselective synthesisStereoisomerismAmidesOxindoles0104 chemical scienceschemistryWittig reactionEnantiomerOrganic Letters
researchProduct

Autophagy

2012

Klionsky, Daniel J. et al.

autophagy assays[SDV]Life Sciences [q-bio]AutolysosomeAutophagosome maturationautophagosomeBioinformaticsstressChaperone-mediated autophagyModelsLC3MESH: Animalsguidelinesautolysosome autophagosome flux LC3 lysosome phagophore stress vacuoleSettore BIO/06 - Anatomia Comparata E CitologiaComputingMilieux_MISCELLANEOUSSettore BIO/17Autophagy databaseautolysosome3. Good healthddc:540lysosomeEnergy and redox metabolism Mitochondrial medicine [NCMLS 4]methods [Biological Assay]Biological AssaySettore BIO/17 - ISTOLOGIANeuroniMAP1LC3BHumanautophagygenetics [Autophagy]AutofagiaMESH: Autophagy*/genetics[SDV.BC]Life Sciences [q-bio]/Cellular BiologyAutofagia; Neuroni; istologiaBiologyModels BiologicalLC3; autolysosome; autophagosome; flux; lysosome; phagophore; stress; vacuoleddc:570AutophagyAnimalsHumansAutophagy-Related Protein 7[SDV.BC] Life Sciences [q-bio]/Cellular BiologyBiological Assay/methodsMolecular BiologyBiologyAutophagy; guidelines; autophagy assaysistologiaphagophoreMESH: HumansAnimals; Biological Assay; Humans; Models Biological; AutophagyvacuoleAnimal[ SDV.BC ] Life Sciences [q-bio]/Cellular BiologyMESH: Models BiologicalPathogenesis and modulation of inflammation Infection and autoimmunity [N4i 1]Cell BiologyBiologicalAutophagy/geneticsfluxAutophagosome membraneAutophagy Protein 5Human medicineMESH: Biological Assay/methods*Neuroscienceautolysosome; autophagosome; flux; LC3; lysosome; phagophore; stress; vacuoleAutophagy
researchProduct

Mitochondria and T2D: Role of Autophagy, ER Stress, and Inflammasome.

2020

Type 2 diabetes (T2D) is one of the main current threats to human health. Both T2D and its numerous clinical complications are related to mitochondrial dysfunction and oxidative stress. Over the past decade, great progress has been made in extending our knowledge about the signaling events regulated by mitochondria. However, the links among mitochondrial impairment, oxidative stress, autophagy, endoplasmic reticulum (ER) stress, and activation of the inflammasome still need to be clarified. In light of this deficit, we aim to provide a review of the existing literature concerning the complicated crosstalk between mitochondrial impairment, autophagy, ER stress, and the inflammasome in the mo…

autophagyMitochondrial DiseasesInflammasomesEndocrinology Diabetes and Metabolism030209 endocrinology & metabolismMitochondrionmedicine.disease_causeInflammasome03 medical and health sciences0302 clinical medicineEndocrinologyinflammasomemedicineAutophagyAnimalsHumansbusiness.industryEndoplasmic reticulumAutophagyMolecular pathogenesisInflammasomeType 2 diabetesEndoplasmic Reticulum StressCell biologyMitochondriamitochondriaCrosstalk (biology)Oxidative StressDiabetes Mellitus Type 2Unfolded protein responsetype 2 diabetesbusinessOxidative stressmedicine.drugTrends in endocrinology and metabolism: TEM
researchProduct

Novel Insights into the Cellular Localization and Regulation of the Autophagosomal Proteins LC3A, LC3B and LC3C

2020

Macroautophagy is a conserved degradative process for maintaining cellular homeostasis and plays a key role in aging and various human disorders. The microtubule-associated protein 1A/1B light chain 3B (MAP1LC3B or LC3B) is commonly analyzed as a key marker for autophagosomes and as a proxy for autophagic flux. Three paralogues of the LC3 gene exist in humans: LC3A, LC3B and LC3C. The molecular function, regulation and cellular localization of LC3A and LC3C have not been investigated frequently, even if a similar function to that described for LC3B appears likely. Here, we have selectively decapacitated LC3B by three separate strategies in primary human fibroblasts and analyzed the evoked e…

autophagysequestosome 1 (p62)LC3CATG8GABARAPGABARAPCellular homeostasisProtein lipidationsirtuin 1ArticleCell LineAntibody SpecificityHumansSirtuinsAmino Acid SequenceLC3BRNA Small InterferingLC3Alcsh:QH301-705.5PhylogenyCellular localizationCell NucleusBinding SitesbiologyChemistrySirtuin 1AutophagosomesAutophagy-Related Protein 8 FamilyGeneral MedicineFibroblastsLipidsCell biologyProtein Transportlcsh:Biology (General)Gene Knockdown TechniquesSirtuinbiology.proteinApoptosis Regulatory ProteinsMicrotubule-Associated ProteinsATG8MAP1LC3BSubcellular FractionsCells
researchProduct

Palladium(II)-Mediated Addition of Benzenediamines to Isocyanides: Generation of Three Types of Diaminocarbene Ligands Depending on the Isomeric Stru…

2016

Coupling of the palladium-bis(isocyanide) complexes cis-[PdCl2(CNR)2] (R = 2,6-Me2C6H3 1, 2-Cl-6-MeC6H3 2) with benzene-1,3-diamine (BDA1) leads to the diaminocarbene species cis-[PdCl2(CNR){C(NHR)═NH(1,3-C6H4NH2)}] (5 and 6, respectively). In this reaction, BDA1 behaves as a monofunctional nucleophile that adds to one of the RNC ligands by one amino group. By contrast, the reaction of 1 and 2 with benzene-1,4-diamine (BDA2) involves both amino functionalities of the diamine and leads to the binuclear species [cis-PdCl2(CNR){μ-C(NHR)═NH(1,4-C6H4)NH═C(NHR)}-(cis)-PdCl2(CNR)] (6 and 7) featuring two 1,4-bifunctional diaminocarbene ligands. The reaction of cis-[PdCl2(CNR)2] (R = cyclohexyl 3) …

benzenediamines010405 organic chemistryStereochemistryIsocyanideOrganic Chemistrychemistry.chemical_elementdiaminocarbenespalladium complexes010402 general chemistry01 natural sciences0104 chemical sciencesInorganic Chemistrychemistry.chemical_compoundchemistryNucleophileDiamineisomersPhysical and Theoretical ChemistryCarbeneta116PalladiumOrganometallics
researchProduct

Supplementary material 1 from: Heller K-G, Hemp C, Massa B, Kociński M, Warchałowska-Śliwa E (2018) Paraplangia sinespeculo, a new genus and species …

2019

Supplementary material 1 from: Heller K-G, Hemp C, Massa B, Kociński M, Warchałowska-Śliwa E (2018) Paraplangia sinespeculo, a new genus and species of bush-cricket, with notes on its biology and a key to the genera of Phaneropterinae (Orthoptera: Tettigonioidea) from Madagascar. Journal of Orthoptera Research 27(2): 143-153. https://doi.org/10.3897/jor.27.24243

bioacousticschromosomesduettingAmblycoryphiniOrophus
researchProduct

Supplementary material 2 from: Heller K-G, Hemp C, Massa B, Kociński M, Warchałowska-Śliwa E (2018) Paraplangia sinespeculo, a new genus and species …

2019

Supplementary material 2 from: Heller K-G, Hemp C, Massa B, Kociński M, Warchałowska-Śliwa E (2018) Paraplangia sinespeculo, a new genus and species of bush-cricket, with notes on its biology and a key to the genera of Phaneropterinae (Orthoptera: Tettigonioidea) from Madagascar. Journal of Orthoptera Research 27(2): 143-153. https://doi.org/10.3897/jor.27.24243

bioacousticschromosomesduettingAmblycoryphiniOrophus
researchProduct

Pheromone-binding proteins of scarab beetles.

1998

: We have characterized Pheromone binding proteins (PBPs) present in the antennae of several species of scarab beetles. In most cases there was only one class of PBP, which was expressed in both sexes. Both Anomala osakana and Popillia japonica possess a single PBP, highly homologous to each other. In each species the same PBP seems to recognize both enantiomers of japonilure, which have opposite biological functions, i.e., the sex Pheromone and the behavioral antagonist (stop signal). The purified PBP of A. osakana binds both enantiomers apparently with the same low affinity. Unexpectedly, these ligands were bound by moth PBPs, which utilize Pheromones with unrelated structures. These find…

biologyAnomala osakanaLigandGeneral Neurosciencebiochemical phenomena metabolism and nutritionbiology.organism_classificationGeneral Biochemistry Genetics and Molecular BiologyChemoreceptor CellsPheromonesColeopteraLow affinityHistory and Philosophy of ScienceBiochemistrySex pheromoneBotanyPopilliapolycyclic compoundsHomologous chromosomebacteriaAnimalsInsect ProteinsPheromone bindingEnantiomerAnnals of the New York Academy of Sciences
researchProduct

FISH mapping of 18S rDNA and (TTAGGG)n sequences in two pipefish species (Gasteroisteiformes: Syngnathidae).

2006

1Istituto di Scienze Marine, Sezione di Venezia, CNR, Castello 1364/a, 30122 Venezia, Italy 2Dipartimento di Biologia Animale, Universita di Palermo, Via Archirafi 18, 90123 Palermo, Italy 3Dipartimento di Scienze Ambientali, Universita “Ca’ Foscari”, Castello 2737/b 30122 Venezia, Italy 4Istituto di Ecologia e Biologia Ambientale, Universita di Urbino “Carlo Bo”, Via I. Maggetti 22, 61029 Urbino (PU), Italy

biologyBase SequenceZoologyChromosome MappingTelomerebiology.organism_classificationPipefishDNA RibosomalSmegmamorphaFisherySyngnathidaeGeneticsRNA Ribosomal 18SFish <Actinopterygii>Animals18s rdnaIn Situ Hybridization FluorescenceRepetitive Sequences Nucleic AcidJournal of genetics
researchProduct