Search results for "SoMe"
showing 10 items of 5114 documents
Individuality of responses to bilateral and unilateral volume equated hypertrophic strength training in physically active men
2019
Purpose. The purpose of the present study was to investigate possible differences between unilateral and bilateral strength training during ten weeks progressive hypertrophic strength training and six weeks detraining period. Furthermore, it was examined possible different individual responders in muscle hypertrophy during strength training and, how those different responders would behave during the detraining phase following the training period. Methods. The present intervention included ten weeks of progressive hypertrophic resistance training followed by six weeks of detraining in healthy young men (n=24). Ultrasound was used to measure vastus lateralis (VL) muscle cross-sectional area (…
Isometric force-time parameters in monitoring of strength training : with special reference to acute responses to different loading resistances
2017
The aim of the present series of studies was to investigate acute neuromuscular responses to (1) different strength training loadings and using (2) different external resistances. In addition, chronic adaptations and dynamic performances were compared to (3) the changes in isometric force-time parameters at the group level, and to (4) the individual timing of the improvement in the rate of force development (RFD) due to hypertrophic or maximum strength followed by power strength training periods. The latter one was achieved by systematic, repeated monitoring. Sixty-nine physically active men (20-35 yrs), but not experienced in resistance training, took part in the present series of studies.…
The Concordance between Teachers’ and Parents’ Perceptions of School Transition Practices: A Solid Base for the Future
2015
This study focuses on parents’ and teachers’ perceptions of practices aimed at easing the transition to formal schooling (e.g., familiarization with the school, discussions about the school entrants). A total of 230 preschool teachers, 131 elementary school teachers, and 2,662 mothers and fathers filled in a questionnaire containing items on how important they considered different preschool-school transition practices. The participants considered the various transition practices to be at least somewhat important. On average, familiarization with the school was considered to be most important, whereas teacher co-operation and joint writing of curricula were considered to be least important. …
Plant-herbivorous beetle networks : molecular characterization of trophic ecology within a threatened steppic environment
2015
DNA barcoding facilitates many evolutionary and ecological studies, including the examination of the dietary diversity of herbivores. In this study, we present a survey of ecological associations between herbivorous beetles and host plants from seriously threatened European steppic grasslands. We determined host plants for the majority (65%) of steppic leaf beetles (55 species) and weevils (59) known from central Europe using two barcodes (trnL and rbcL) and two sequencing strategies (Sanger for mono/oligophagous species and Illumina for polyphagous taxa). To better understand the ecological associations between steppic beetles and their host plants, we tested the hypothesis that leaf beetl…
ChemInform Abstract: Regioisomeric 5(3)-Aminomethyl-3(5)-phenylisoxazoles: Synthesis, Spectroscopic Discrimination, and Muscarinic Activity.
2010
The regioselective synthesis of isomeric 5(3)-aminomethyl-3(5)-phenyl isoxazoles using different methods is described. Spectroscopic data, especially mass spectrometric fragmentation, were used to identify and characterize the regioisomers. The muscarinic activity of these isoxazoles was assayed on isolated guinea-pig ileum and atria as well as on isolated rabbit vas deferens. Regioisomere 5(3)-Aminomethyl-3(5)-phenyl-isoxazole: Synthese, spektroskopische Unterscheidung und muskarinische Aktivitat Es werden verschiedene Verfahren zur regioselektiven Darstellung von 5(3)-Aminomethyl-3(5)-phenyl-isoxazolen beschrieben, die anhand ihrer spektroskopischen Daten, insbesondere der massenspektrosk…
Treatment of B-CLL Cells with Bortezomib and Rituximab Reduces Cell Viability In Vitro..
2004
Introduction : In B-CLL, somatic mutation of IgVH genes defines a group of patients with favorable prognosis, whereas the absence of IgVH mutations is correlated with a worse outcome. Our previous data suggested that BCL-6 mutations identify a subgroup of patients with high risk of progression despite the presence of mutated IgVH gene, but the clinical significance of this molecular alteration remains uncertain. New approaches are now being tested for the treatment of B-CLL. Proteasome inhibitor, Bortezomib (Btz), and monoclonal antibodies specific for surface antigens, Rituximab (Rtx), represent potential therapeutic strategy. Objetives : To study the effects of Btz and Rtx on viability of…
Proton magnetic resonance imaging with para-hydrogen induced polarization.
2012
A major challenge in imaging is the detection of small amounts of molecules of interest. In the case of magnetic resonance imaging (MRI) their signals are typically concealed by the large background signal of e.g. the body. This problem can be tackled by hyperpolarization which increases the NMR signals up to several orders of magnitude. However, this strategy is limited for (1)H, the most widely used nucleus in NMR and MRI, because the enormous number of protons in the body screens the small amount of hyperpolarized ones. Here, we describe a method giving rise to high (1)H MRI contrast for hyperpolarized molecules against a large background signal. The contrast is based on the J-coupling i…
Fine Mapping of Gene Ordering by Elongated Chromosome Methods
2006
Publisher Summary Fluorescence in situ hybridization (FISH) can be used to localize specific DNA sequences on metaphase chromosomes, interphase nuclei, and experimentally extended DNA or chromatin fibers. Depending on the hybridization target, FISH techniques show widely different levels of DNA resolution. Mechanically stretched or elongated chromosomes fill the resolution gap between metaphase FISH and fiber FISH, allowing the rapid and straightforward ordering and localization of clones along the length of an entire chromosome with a 100- to 200-kb resolution. Although various genome projects have provided very high-resolution physical maps of human and important animal genomes, FISH is s…
Entering the Nano-Cosmos of the Cell by Means of Spatial Position Determination Microscopy (SPDM): Implications for Medical Diagnostics and Radiation…
2013
During the last 20 years fluorescence light microscopy has made an enormous progress towards fluorescence nanoscopy in order to elucidate the nanostructural organization of cellular machineries beyond classical limits of resolution in light microscopy. One of these novel techniques is Spatial Position Determination Microscopy (SPDM), an approach of molecular localization microscopy based on the application of specific fluorescence labelling of cellular structures by means of dyes that undergo reversible photobleaching resulting in blinking effects during image acquisition. This blinking allows spectral separation of individual molecules and thus precise localization and distances measuremen…
Isolation and Characterization of Pathogen-Bearing Endosomes Enable Analysis of Endosomal Escape and Identification of New Cellular Cofactors of Infe…
2013
Many pathogens, including viruses, bacteria, as well as bacterial toxins, enter their target cells by endocytosis leading to accumulation of pathogenic and cellular proteins in endosomes. Here, we present detailed experimental instructions on isolation of endosomes after virus infection and their subsequent biomolecular characterization. The isolation of endosomes is based on discontinuous sucrose gradient centrifugation, where different endosomal compartments accumulate at a specific sucrose interface. This enables the enrichment and separation of the virus-interacting and co-internalized cell-surface receptors and membrane-associated proteins. The endosomal fractions can be further analyz…