ChemInform Abstract: Regioisomeric 5(3)-Aminomethyl-3(5)-phenylisoxazoles: Synthesis, Spectroscopic Discrimination, and Muscarinic Activity.

6533b81ffe1ef96bd1277a97

RESEARCH PRODUCT

ChemInform Abstract: Regioisomeric 5(3)-Aminomethyl-3(5)-phenylisoxazoles: Synthesis, Spectroscopic Discrimination, and Muscarinic Activity.

Stefan Laufer Gerd Dannhardt Günter Lambrecht Ernst Mutschler J. Schweiger

subject

medicine.anatomical_structure Stereochemistry Chemistry Muscarinic acetylcholine receptor Structural isomer Vas deferens medicine General Medicine Mass spectrometric

description

The regioselective synthesis of isomeric 5(3)-aminomethyl-3(5)-phenyl isoxazoles using different methods is described. Spectroscopic data, especially mass spectrometric fragmentation, were used to identify and characterize the regioisomers. The muscarinic activity of these isoxazoles was assayed on isolated guinea-pig ileum and atria as well as on isolated rabbit vas deferens. Regioisomere 5(3)-Aminomethyl-3(5)-phenyl-isoxazole: Synthese, spektroskopische Unterscheidung und muskarinische Aktivitat Es werden verschiedene Verfahren zur regioselektiven Darstellung von 5(3)-Aminomethyl-3(5)-phenyl-isoxazolen beschrieben, die anhand ihrer spektroskopischen Daten, insbesondere der massenspektroskopischen Fragmentierung, zuverlassig unterschieden werden konnen. Am isolierten Meerschweinchenileum bzw.-atrium sowie am isolierten Vas deferens des Kaninchens wird die muskarinische Aktivitat der phenylsubstituierten Aminomethylisoxazole gepruft.

year	journal	country	edition	language
2010-08-17	ChemInform

https://doi.org/10.1002/chin.199538164

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