Search results for "SoMe"
showing 10 items of 5114 documents
Taksometru pakalpojumu nozares novērtējuma “A” saimnieciskās darbības analīze
2017
Maģistra darba tēma ir “Taksometru pakalpojumu nozares uzņēmuma “A” saimnieciskās darbības analīze”. Maģistra darba mērķis ir izpētīt taksometru pakalpojumu nozares uzņēmuma “A” saimniecisko darbību un nozari, kurā tas darbojas, novērtēt finansiālo situāciju, izvērtēt attīstības iespējas un veikt uzņēmuma darbinieku aptauju un izstrādāt priekšlikumus uzņēmumu vadībai situācijas uzlabošanai. Maģistra darbs sastāv no 4 daļām: pirmajā - taksometru pārvadājumu nozares analīze; otrajā – uzņēmuma saimnieciskās darbības analīze; trešajā - finansiāla stāvokļa novērtējums, ceturtajā - bankrota iespējamības izvērtēšana. Darba apjoms ir 97 lpp., tajā ir ietvertas 6 tabulas, 53 attēli un 4 pielikumi.
Clostridium difficile Induced Inflammasome Activation and Coagulation Derangements
2022
C. difficile enterocolitis (CDAC) is the most common hospital infection, burdened by an increased incidence of coagulation-related complications such as deep vein thrombosis (DVT) and disseminated intravascular coagulation (DIC) as well as a significant sepsis-related mortality. In this review, we analyzed the available data concerning the correlation between coagulation complications related to C. difficile infection (CDI) and inflammasome activation, in particular the pyrin-dependent one. The little but solid available preclinical and clinical evidence shows that inflammasome activation increases the risk of venous thromboembolism (VTE). As proof of this, it has been observed that in vitr…
Microchimerism in multiple sclerosis: The association between sex of offspring and MRI features in women with multiple sclerosis
2023
AimsDuring pregnancy, fetal cells can migrate to the mother via blood circulation. A percentage of these cells survive in maternal tissues for decades generating a population of fetal microchimeric cells (fMCs), whose biological role is unclear. The aim of this study was to investigate the association between the sex of offspring, an indirect marker of fMCs, and magnetic resonance imaging (MRI) features in women with multiple sclerosis (MS).MethodsWe recruited 26 nulliparous MS patients (NPp), 20 patients with at least one male son (XYp), and 8 patients with only daughters (XXp). Each patient underwent brain MR scan to acquire 3D-T2w FLAIR FatSat and 3D-T1w FSPGR/TFE. Lesion Segmentation To…
Microchimerism and multiple sclerosis: a study on the impact of the sex of offspring on clinical, radiological, and paraclinical features of maternal…
2023
Background. Multiple sclerosis (MS) is a chronic autoimmune disorder characterised by inflammation and neurodegeneration and representing one of the most common causes of neurologic disability among young adults. Over the last 40 years, several authors have confirmed the existence of fetal cells in maternal blood and their pregnancy-related origin, demonstrating that pregnancy may establish a long-term, low-grade chimeric state in women. The biological and clinical significance of fetal microchimeric cells (fMCs) in maternal health is largely unknown, although a role in autoimmune diseases have been hypothesised. Aims. The overarching aim of my PhD dissertation was to investigate the role o…
Identification of a new nonsense mutation (Tyr129Stop) of the SRY gene in a newborn infant with XY sex-reversal.
2004
Point mutations and deletions of SRY gene have been described in several cases of XY gonadal dysgenesis. To date, most of these mutations affect the HMG domain of SRY which plays a central role in DNA binding activity of SRY. We report on a non-mosaic XY sex-reversed newborn girl (completely female external genitalia). The direct sequencing of SRY showed a new nonsense mutation in a codon of SRY gene flanking the 3' end of the HMG domain: a thymine is replaced by a guanine at position +387 in codon 129, resulting in the replacement of the amino acid tyrosine (TAT) by a stop codon (TAG). The new mutation of this patient provides further evidence to support the functional importance of the pu…
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
2009
We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, risk ratio [RR]=1.19; P=2.3×10−7), an association that was replicated in the German AF Network (odds ratio=1.44; P=1.6×10−11). Combining the discovery and replication results, rs2106261 was significantly associated with AF (RR=1.25; P=1.8×10−15).
Skin Immunomodulation during Regeneration: Emerging New Targets
2021
Adipose-Derived Stem Cells (ADSC) are present within the hypodermis and are also expected to play a pivotal role in wound healing, immunomodulation, and rejuvenation activities. They orchestrate, through their exosome, the mechanisms associated to cell differentiation, proliferation, and cell migration by upregulating genes implicated in different functions including skin barrier, immunomodulation, cell proliferation, and epidermal regeneration. ADSCs directly interact with their microenvironment and specifically the immune cells, including macrophages and T and B cells, resulting in differential inflammatory and anti-inflammatory mechanisms impacting, in return, ADSCs microenvironment and …
The Process of Selecting Influencers for Marketing Purposes in an Organisation
2023
Influencer marketing practices are growing on social media channels, while the usage of other mass-media channels is decreasing, prompting organisations to search for new tools with which to communicate efficiently with their target audiences. Influencers can affect purchase intentions if the audience identifies with them. For a successful collaboration with an influencer, an organisation needs to ensure that the brand fit is suitable, as the audience will become suspicious if the paid collaboration is too apparent. In addition, an organisation can ask an influencer to perform many roles during the collaboration. The objectives of this study, therefore, are to discover how organisations ens…
The Role of Social Media Influencers in Public Health Communication: Case COVID-19 Pandemic
2022
During public health crises, public organizations face a variety of strategic communication challenges, and the outbreak of the COVID-19 pandemic in 2020 is an extreme example. In Finland, the Prime Minister’s Office initiated a communication campaign that utilized social media influencers to communicate timely instructions regarding the pandemic. However, it is uncertain how social media influencers adapt to briefings of public organizations given that they typically work with brands that align with their own interests and expertise, which rarely is epidemiology. We use the two-step flow of communication model and social influence theory to analyze research data that consisted of 96 Instag…
Somevaikuttajat koronaviestinnässä : Faktaa koronasta -kampanjan analyysia
2021
Somevaikuttajat kutsuttiin mukaan valtioneuvoston koronaviestintään keväällä 2020. Vaikuttajien somepostausten ja seuraajien kommenttien analysointi kielii siitä, että Suomessa elettiin vielä pandemian alkutaipaleella yhtenäisyyden aikaa. nonPeerReviewed