Search results for "Soft tissue sarcoma"
showing 9 items of 49 documents
Optical coherence tomography and Raman spectroscopy for ex vivo characterization of canine skin and subcutaneous tumors: preliminary results
2021
Cancer is one of the leading causes of companion animal mortality. Up to 30% of all canine and feline tumors appear on or directly under the skin. To date, only a limited number of studies applied biophotonics techniques for optical characterization and detection of tumors in pets. In this work, we acquired ex vivo optical coherence tomography (OCT) images and Raman spectra of native skin and the most common canine and feline skin and subcutaneous tumors; lipomas, mast cell tumors, and soft tissues sarcomas. Lipomas exhibited the most distinctive tissue morphology (i.e., honeycomb structure) and biochemistry (lipid-related Raman peaks of 1063, 1301, and 1652 cm-1). Moreover, lipomas had sig…
Pulmonary metastasectomy in soft tissue sarcomas: a systematic review
2021
Background Soft tissue sarcoma (STS) tend to metastasis to the lungs. Pulmonary metastasectomy seems to be a common practice always when plausible. The objective of this article was to review systematically the results of a literature search on pulmonary metastasectomy for STSs published in the last ten years and to offer a brief overview about the current practice as well. Methods Eight retrospective studies published in the period 2010-2020, which included patients with pulmonary metastases and metastasectomy were selected. Indication for surgery, survival rate and factors influencing survival were the primary outcomes, while further interesting findings in the studies were also collected…
Soft tissue sarcoma in Italy: From epidemiological data to clinical networking to improve patient care and outcomes
2019
Sarcomas are rare malignant neoplasms that develop from mesenchymal cells and include a heterogeneous and large group of histological subtypes that may occur at any anatomical site. Soft tissue sarcomas (STS), the focus of this review, account for ≈70‒80% of sarcomas and represent <1% of all cancers. The heterogeneity of STS applies to both their topography and morphology, and 5-year survival can vary widely depending on disease stage and the complex interplay between anatomical site and histology for different STS subtypes. The rarity and heterogeneity of STS, together with other factors, such as the lack of clinical expertise often lead to difficulties and delays in making an accurate …
Tumor response assessment by modified Choi criteria in localized high-risk soft tissue sarcoma treated with chemotherapy.
2012
BACKGROUND. The objective of this study was to compare the prognostic relevance of Response Evaluation Criteria in Solid Tumors (RECIST) versus Choi criteria for the assessment of response in patients with high-risk soft tissue sarcoma of the extremities or trunk wall who received preoperative chemotherapy with or without radiotherapy in a phase 3 trial. METHODS. Patients received 3 cycles of preoperative epirubicin þ ifosfamide with or without radiotherapy. The diagnostic concordance between RECIST and Choi criteria and their correlation with overall survival (OS) and freedom from progression (FFP) were evaluated in a univariate Cox regression model. RESULTS. In 243 of 321 eligible patient…
CHEMO-RESISTANT SOFT-TISSUE SARCOMAS (STS). Experience of the Italian Cooperative Study (ICS)
1993
The purpose of this study is to evaluete the Italian experience about localized Fivrosarcomas (FS) and Neurogenic Darcomas (NS)
ROLE of SURGERY for NONMETASTATIC ABDOMINAL RRHABDOMYOSARCOMAS. A Report from the Italian and German Cooperative Groups Studies.
2003
In the current study, the Authors aim to evaluate clinical features and treatment results observed in patients from the German and Italian studies who had nonmetastatic abdominal rhabdomyosarcomas.
Initial surgery for localized rhabdomyosarcoma: a report from the italian Soft Tissue Sarcoma Cooperative Group Studies.
2005
Objective. Analysis of the initial surgical approach in patients with localized rhabdomyosarcoma, enrolled in Italian Studies (1979-2003). Methods. Surgical records of 587 patients were evaluated. As primary surgery, the excision was recommended if microscopically complete, otherwise biopsy was preferable. Results. The initial biopsy, performed in almost 50% of patients in RMS-79 protocol, has been adopted more often in the protocol RMS-88 and 96. However, the “complete resection” rate has remained quite stable through the years, as well as the percentage of microscopic residue. The macroscopic residue disease has been more important in RMS-88 study than in RMS-96. Most GUnBP tumors and abo…
Treatment challenges in and outside a network setting: Soft tissue sarcomas
2019
Patients with soft tissue sarcoma (STS) experienced better outcomes when treated according to existing clinical practice guidelines either at reference institution or dedicated treatment networks. Despite increasing evidence supporting referral to sarcoma specialised units, up to half of patients are not managed according to guidelines, particularly those in the early stage of their disease requiring surgery. Also, criteria to certify expertise of institutions, such as the treatment volume, are debated and health authorities have only recently started identification of these centres and creation of treatment networks in Europe as well as in several countries. This process have important imp…