Search results for "Solid"
showing 10 items of 3575 documents
Preparation and recrystallization behavior of spray-dried co-amorphous naproxen–indomethacin
2016
To improve the dissolution properties and the physical stability of amorphous active pharmaceutical ingredients, small molecule stabilizing agents may be added to prepare co-amorphous systems. The objective of the study was to investigate if spray-drying allows the preparation of co-amorphous drug-drug systems such as naproxen-indomethacin and to examine the influence of the process conditions on the resulting initial sample crystallinity and the recrystallization behavior of the drug(s). For this purpose, the process parameters inlet temperature and pump feed rate were varied according to a 2(2) factorial design and the obtained samples were analyzed with X-ray powder diffractometry and Fo…
Naringenin Nano-Delivery Systems and Their Therapeutic Applications
2021
Naringenin (NRG) is a polyphenolic phytochemical belonging to the class of flavanones and is widely distributed in citrus fruits and some other fruits such as bergamot, tomatoes, cocoa, and cherries. NRG presents several interesting pharmacological properties, such as anti-cancer, anti-oxidant, and anti-inflammatory activities. However, the therapeutic potential of NRG is hampered due to its hydrophobic nature, which leads to poor bioavailability. Here, we review a wide range of nanocarriers that have been used as delivery systems for NRG, including polymeric nanoparticles, micelles, liposomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), nanosuspensions, and nano…
Mediación y acuerdos reparatorios en la metamorfósica justicia penal del siglo XXI
2020
El siglo XXI ha supuesto la consolidación del sistema acusatorio en la mayor parte de los países occidentales. Este sistema no solo comporta un cambio de norma, sino también un cambio de cultura procesal. En esa nueva cultura se han incorporado procedimientos que permiten los acuerdos y pactos; por ejemplo, en unos casos con el Ministerio Público, como sucede con las conformidades; en otros, acuerdos entre víctima y victimario, que permiten trabajar desde y con las personas, y favorecen la reparación. En un panorama de ultrapunitivismo, la justicia restaurativa y la mediación, como cauces que favorecen el diálogo, se presentan como un retorno a las personas, una bocanada de aire fresco.
«Per non dar moto alle fabriche»: l'ingegnere regio Scipione Basta e la costruzione della cappella Roano nel duomo di Monreale
2015
«PER NON DAR MOTO ALLE FABBRICHE»: THE ROYAL ENGINEER SCIPIONE BASTA AND THE CONSTRUCTION OF THE ROANO CHAPEL IN THE CATHEDRAL OF MONREALE. In December 1686 the Royal Engineer Scipione Basta, a personality still largely to be investigated but which seems to portend a specific expertise in techno-constructive issues and in particular in structural reinforcement, was appointed by the Viceroyal Government to draw up a technical report concerning some delicate constructive aspects of the project of the architect fra Giovanni da Monreale for the chapel commissioned by the archbishop Roano for the cathedral. Due to the particular configuration of the building to be constructed –a domed octagonal …
Minimally invasive interval debulking surgery in ovarian neoplasm (MISSION trial–NCT02324595): a feasibility study
2016
Background Laparoscopy has acquired an increasing role in the management of ovarian cancer. Laparoscopic cytoreduction could represent a new frontier for selected patients after neoadjuvant chemotherapy (NACT). Objective We sought to assess feasibility and early complication rate of minimally invasive (MI) interval debulking surgery (IDS) in stage III-IV epithelial ovarian cancer (EOC) patients after NACT. Study Design This is a phase II multicentric study in advanced EOC cases with clinical complete response after NACT, according to Gynecologic Cancer Intergroup and Response Evaluation Criteria In Solid Tumors criteria. Institutional review board approval was obtained and all patients sign…
Automated parametric neutronics analysis of the Helium Cooled Pebble Bed breeder blanket with Be 12 Ti
2017
The Helium Cooled Pebble Bed (HCPB) breeder blanket is being developed as part of the European Fusion Programme. Part of the programme is to investigate blanket designs relevant for future demonstration fusion power plants. This paper presents neutronics analyses of the HCPB with an alternative neutron multiplier, Be12Ti which is incorporated into the design, replacing the current Be multiplier. A parameter study was performed for a range of geometries to identify the optimal heights of the lithium ceramic and neutron multiplier pebble beds. Automated creation of CAD models followed by conversion to constructive solid geometry (CSG) and unstructured mesh (UM) geometry allows the models to b…
Reaction Sequence in the Preparation of NiAl2O4 Spinel-Mullite Composites by Sol-Gel
2005
NiAl 2 O 4 spinel-mullite composites were prepared by simultaneous replacement of Al by Ti and/or Ni in 3:2 stoichiometric mullite. Specimens having nominal compositions 3(Al 2-2x Ni x Ti x O 3 ).2SiO 2 (x = 0, 0.025, 0.05, 0.2) and 3(Al 2-x M x O 3) .2SiO 2 (M = Ni 2+ or Ti 4+ and x = 0.05) were synthesized by sol-gel techniques, which provide homogeneous gels in the SiO 2 -Al 2 O 3 system. Gel structures investigated by infrared (IR) spectroscopy revealed the formation of Al-O-Si bonds in dried gels. The reaction sequence of gel-derived glasses, previously obtained by preheating gels at 750°C for 3 h, was evaluated by X-ray powder diffraction (XRD) and ultraviolet-visible (UV-vis) spectro…
X-ray absorption spectroscopy studies of the off-center Ni2+ions in Ni c Mg 1-c O solid solutions
1996
In this work we present the x-ray absorption spectroscopy study of NicMg1-cO (0.01 <EQ c <EQ 1) solid solutions. The extended x-ray absorption fine structure (EXAFS) above the Ni K-edge was analyzed using the multi-shell fitting procedure. It was found that nickel ions are located in a distorted environment and shift upon dilution to the off- center positions. This fact follows from two main results: (1) in the first shell, the average Ni- O distance increases linearly upon dilution; (2) in the second shell, the average Ni-Ni distance remains unchanged and decreases slightly at low nickel concentration while the dependence of the Ni-Mg distance has a break at c approximately equals 0.6 and …
Analysis of Nicotine and Its Oxidation Products in Nicotine Chewing Gum by a Molecularly Imprinted Solid-Phase Extraction
2000
Chromatographic stationary phases showing exceptional selectivity for nicotine can be prepared by the technique of molecular imprinting. Such phases were used in the search for a rapid cleanup step for nicotine and some of its oxidation products in chewing gum formulations. Thus, using an organic mobile phase, the nicotine analytes from chewing gums dissolved in nonpolar solvent were retained, whereas the nonpolar matrix eluted close to the void peak. A subsequent switch to an acidic mobile phase resulted in elution of the analytes as one sharp peak. Due to weak binding of the less basic oxidation products, other imprinted polymers were tested, and the solid-phase extraction procedure was o…
A lack of meaning?
2020
This article explores the ‘lack of meaning’ in contemporary society as a consequence of Western dualist thought paradigms and ontologies, via Gilles Deleuze’s concept of ‘reactive nihilism’ following the colloquial murder of God. The article then explores processual and new materialist approaches in the understanding of the lived and carnal self, arguing for immanent and senseful materiality as an ethical platform for religious, environmental, and societal solidarity for tomorrow. For the theoretical justification of the processual approach in understanding the enfleshed self, the article employs John Dupré’s processual approach in the philosophy of biology, as well as Astrida Neimani’s cri…