Search results for "Solid"

Sosiaalisen solidaarisuuden käänne vammaisten lasten tutkimuksessa

2019

Artikkelissa luomme katsauksen vammaisten lasten tutkimuksessa tapahtuneisiin tutkimusparadigman muutoksiin. Pohdimme, millaiset vammaisuuteen liittyvät käsitykset ja määritelmät vaikuttavat siihen, miten tutkimme ”vammaista lasta”.  Tarkastelemme muutoksia vammaisuuden määrittelyssä ja määrittelyjen vaikutuksia käytäntöihin erityisesti koulutuksellisen inkluusion kontekstissa. Määritelmät ja tutkimusorientaatiot ovat muuttuneet vammaisten yhteiskunnallisen aseman muutoksien myötä. 1980-luvulta lähtien haavoittuvuuden sijaan tutkimuksessa on kiinnitetty huomiota lasten oikeuksiin ja heidän toimijuutensa. Samalla yksilön oikeuksia korostavia, uusliberalistisia diskursseja on myös kritisoitu …

Fish Welfare in Aquaponic Systems: Its Relation to Water Quality with an Emphasis on Feed and Faeces—A Review

2017

Aquaponics is the combination of aquaculture (fish) and hydroponic cultivation of plants. This review examines fish welfare in relation to rearing water quality, fish feed and fish waste and faeces to develop a sustainable aquaponic system where the co-cultured organisms, fish, bacteria in biofilters and plants, should be considered holistically in all aquaponics operations. Water quality parameters are the primary environmental consideration for optimizing aquaponic production and for directly impacting fish welfare/health issues and plant needs. In aquaponic systems, the uptake of nutrients should be maximised for the healthy production of the plant biomass but without neglecting the best…

A multicenter phase 1 study of solitomab (MT110, AMG 110), a bispecific EpCAM/CD3 T-cell engager (BiTE®) antibody construct, in patients with refract…

2018

ABSTRACT We assessed the tolerability and antitumor activity of solitomab, a bispecific T-cell engager (BiTE®) antibody construct targeting epithelial cell adhesion molecule (EpCAM). Patients with relapsed/refractory solid tumors not amenable to standard therapy received solitomab as continuous IV infusion in a phase 1 dose-escalation study with six different dosing schedules. The primary endpoint was frequency and severity of adverse events (AEs). Secondary endpoints included pharmacokinetics, pharmacodynamics, immunogenicity, and antitumor activity. Sixty-five patients received solitomab at doses between 1 and 96 µg/day for ≥28 days. Fifteen patients had dose-limiting toxicities (DLTs): e…

Transformative Policies for the Social and Solidarity Economy: The New Generation of Public Policies Fostering the Social Economy in Order to Achieve…

2020

The United Nations Agenda 2030 has recognized that Social Economy (SE) entities play an important role in achieving the Sustainable Development Goals (SDG). In order to maximize the impact of the SE, governments have recently deployed new policies regarding these entities. The objective is to understand the context of policy change that has allowed these policies to emerge, their main characteristics and the critical factors in their construction and implementation. Successful policy cases in Europe and Spain have been studied. Qualitative data have been collected through key policy documents, experts, and focus groups. As a main finding, the study shows that this new model of policies exhi…

L'esprit de famille - Après les réformes du droit des successions et des libéralités

2007

Le droit des successions et des liberalites vient de connaitre, coup sur coup, deux reformes qui renovent profondement la matiere. La famille a cause de mort qui se dessine au travers des regles de l'heritage n'est plus tout a fait la meme. La loi successorale prend en compte le resserrement de la famille autour du couple et des enfants, au detriment de la famille elargie. La solidarite familiale joue toujours son role au travers de la reserve successorale des enfants ou de creances alimentaires dont peuvent eventuellement beneficier les ascendants et les freres et soeurs. Toutefois, le droit nouveau fait une large place a la volonte du de cujus et l'esprit de famille doit necessairement s'…

POTENTIAL APPLICATIONS OF LIQUID BIOPSY IN IMMUNOTHERAPY: ROLE OF EXOSOMES, MICRORNAS AND PLASMA EXPRESSION LEVELS OF IMMUNE CHECKPOINTS IN PATIENTS …

2023

A multiresidue analytical method for trace level determination of antibiotics and antiretroviral drugs in wastewater and surface water using SPE-LC-M…

2016

An analytical method for simultaneous determination of seven commonly used antibiotics and three antiretrovirals in surface water and urban wastewater at the ng L−1 level has been developed. The method involves concentration and clean-up by solid phase extraction (SPE) followed by identification and quantification by liquid chromatography tandem mass spectrometry (LC-ESI-MS/MS). The use of matrix-matched calibration curves constructed by spiking surface water was evaluated for quantification and compared with the internal standard method using isotopically labelled compounds. The method gave absolute recoveries of 41–116% with most of the compounds having recoveries >50%. The LOQs ranged fr…

Localizzazione ipocentrale e clustering degli eventi sismici registrati durante la campagna OBS condotta nel Tirreno meridionale

2011

NGDO brand logos. Sense and evolution

2015

La hipótesis inicial de este artículo es que, desde mediados de los años noventa, la lógica de marca se ha extendido al ámbito de la cooperación y de la ayuda humanitaria. Que en las últimas décadas las grandes ONGD han devenido marcas postmodernas. A manera de ejemplo, hemos estudiado los logos aparecidos en los anuncios de televisión de cinco de estas organizaciones: Intermón Oxfam, Médicos Sin Fronteras, Anesvad, Ayuda en Acción y África Directo. Sin duda, el logo es el primer elemento a considerar para establecer un posicionamiento de marca porque en un logo, además de la identidad visual, se anticipan metonímicamente los relatos y los valores que sustenten la marca, bien sea una marca …

Fiscal consolidation and financial reforms

2015

We use data for a panel of 17 countries over the period 1980-2005 to investigate the impact of fiscal consolidation on the likelihood of financial reforms. We show that fiscal adjustments do not boost the implementation of financial reforms. However, tax-driven fiscal consolidation programs raise the likelihood of banking sector reforms. Moreover, we find that: (i) an increase in the degree of trade openness makes countries less likely to implement financial reforms; (ii) an increase in the interest rate spreads accelerates the path of financial reforms, especially, external capital account reforms; and (iii) an improvement in the quality of political institutions strongly enhances the prob…