Search results for "Solutions"

Topical glaucoma medications – Clinical implications for the ocular surface

2022

Glaucoma is a leading cause of irreversible blindness. The use of topical eye drops to reduce intraocular pressure remains the mainstay treatment. These eye drops frequently contain preservatives designed to ensure sterility of the compound. A growing number of clinical and experimental studies report the detrimental effects of not only these preservatives but also the active pharmaceutical compounds on the ocular surface, with resultant tear film instability and dry eye disease. Herein, we critically appraise the published literature exploring the effects of preservatives and pharmaceutical compounds on the ocular surface. publishedVersion

Helmholtz equation in unbounded domains: some convergence results for a constrained optimization problem

2016

We consider a constrained optimization problem arising from the study of the Helmholtz equation in unbounded domains. The optimization problem provides an approximation of the solution in a bounded computational domain. In this paper we prove some estimates on the rate of convergence to the exact solution.

Carbonic anhydrase inhibitor with topical NSAID therapy to manage cystoid macular edema in a case of gyrate atrophy

2017

Purpose Gyrate atrophy of the choroid and retina (GACR) is a rare chorioretinal dystrophy characterized by a deficiency of the enzyme ornithine aminotransferase, inherited in an autosomal recessive pattern. Case Report We report a case of a 17-year-old girl with GACR, for whom the level of serum ornithine had been reduced by an arginine-restricted diet. The patient was responsive to an association of topical nonsteroidal anti-inflammatory drugs (NSAIDs) and a carbonic anhydrase inhibitor (CAI) to reduce cystoid macular edema (CME). Conclusions The efficacy of topical NSAIDs and systemic CAI association indicates that the imbalance in the distribution of retinal pigment epithelium membrane-b…

Convolution operators with a fundamental solution of finite order

1995

Comparison of the effect of non-polluted and underwater-volcano-polluted seawater on the corrosion resistance of different stainless steels

2015

This work compares the effect of non‐polluted and underwater‐volcano‐polluted seawater on the electrochemical behavior of two different alloys, notably an austenitic stainless steel (SS) and a duplex stainless steel. Polarization measurements, potentiostatic passivation tests, electrochemical impedance spectroscopy and capacitance measurements were performed. Results show that the composition of the polluted seawater negatively affects the passivation kinetics of both AISI 316 SS and Alloy 900, decreasing the corrosion resistance of both alloys. Additionally, when both steels are compared, it can be concluded that passive films formed on Alloy 900 presented better protective properties than…

Chemical and photochemical properties of chloroharmine derivatives in aqueous solutions

2015

Thermal and photochemical stability (ΦR), room temperature UV-vis absorption and fluorescence spectra, fluorescence quantum yields (ΦF) and lifetimes (τF), quantum yields of hydrogen peroxide (ΦH2O2) and singlet oxygen (ΦΔ) production, and triplet lifetimes (τT) have been obtained for the neutral and protonated forms of 6-chloroharmine, 8-chloroharmine and 6,8-dichloroharmine, in aqueous media. When it was possible, the effect of pH and oxygen concentration was evaluated. The nature of electronic transitions of protonated and neutral species of the three investigated chloroharmines was established using Time-Dependent Density Functional Theory (TD-DFT) calculations. The impact of all the fo…

Anisotropic potential of velocity fields in real fluids: Application to the MAST solution of shallow water equations

2013

In the present paper it is first shown that, due to their structure, the general governing equations of uncompressible real fluids can be regarded as an "anisotropic" potential flow problem and closed streamlines cannot occur at any time. For a discretized velocity field, a fast iterative procedure is proposed to order the computational elements at the beginning of each time level, allowing a sequential solution element by element of the advection problem. Some closed circuits could appear due to the discretization error and the elements involved in these circuits could not be ordered. We prove in the paper that the total flux of these not ordered elements goes to zero by refining the compu…

Embedded access points for trusted data and resources access in HPC systems

2010

Biometric authentication systems represent a valid alternative to the conventional username-password based approach for user authentication. However, authentication systems composed of a biometric reader, a smartcard reader, and a networked workstation which perform user authentication via software algorithms have been found to be vulnerable in two areas: firstly in their communication channels between readers and workstation (communication attacks) and secondly through their processing algorithms and/or matching results overriding (replay attacks, confidentiality and integrity threats related to the stored information of the networked workstation). In this paper, a full hardware access poi…

Steady states and nonlinear buckling of cable-suspended beam systems

2018

This paper deals with the equilibria of an elastically-coupled cable-suspended beam system, where the beam is assumed to be extensible and subject to a compressive axial load. When no vertical load is applied, necessary and sufficient conditions in order to have nontrivial solutions are established, and their explicit closed-form expressions are found. In particular, the stationary solutions are shown to exhibit at most two non-vanishing Fourier modes and the critical values of the axial-load parameter which produce their pitchfork bifurcation (buckling) are established. Depending on two dimensionless parameters, the complete set of resonant modes is devised. As expected, breakdown of the p…

Estimation of the effect of the acidosis and alkalosis on the anesthetic potency of local anesthetics by biopartitioning micellar chromatography and …

2004

Local anesthetics are hydrophobic compounds and weak bases with protonation constants ranged between 7.5 and 8.8. These drugs block reversibly nerve conduction near their site of application or injection and thus produce temporary loss of feeling or sensation in a limited area of the body. The efficacy of anesthetic blockade of local anesthetics depends on the charged/uncharged form ratio and the hydrophobicity of the compounds. In addition their toxicological effects have been reported to be highly dependent on the physiological pH. Biopartitioning micellar chromatography (BMC) and micellar electrokinetic chromatography (MEKC), that use micellar solutions as mobile phases, have proven to b…