Search results for "Solutions"
showing 10 items of 757 documents
Retrograde in situ versus antegrade pulmonary preservation in clinical lung transplantation: a single-centre experience.
2014
OBJECTIVE Experimental and clinical studies have indicated a beneficial effect of retrograde lung preservation on post-transplant results. Accordingly, we conducted a non-randomized trial. METHODS A total of 209 consecutive recipients transplanted with low-potassium dextrane (LPD)-preserved lungs were eligible for analysis. Antegrade lung preservation (AP) was performed in 173 patients and retrograde in situ perfusion (RP) in 36 patients using low-potassium dextrane solution in all cases. The prostacycline was added to preservation solution. RESULTS The main donor, graft and recipient characteristics did not differ significantly between groups. There was a beneficial trend toward improved o…
Physicochemical compatibility of mixtures of dornase alfa and tobramycin containing nebulizer solutions
2008
Patients suffering from cystic fibrosis (CF) often need to inhale multiple doses of different nebulizable drugs per day. Patients attempt to shorten the time consuming administration procedure by mixing drug solutions/suspensions for simultaneous inhalation. The objective of this experimental study was to determine whether mixtures of the nebulizer solution dornase alfa (Pulmozyme) with tobramycin nebulizer solutions (TOBI and GERNEBCIN 80 mg) are physico-chemically compatible. Drug combinations were prepared by mixing the content of one respule Pulmozyme with either one respule TOBI or one ampoule GERNEBCIN 80 mg. Test solutions were stored at room temperature and exposed to light. Dornase…
A New Technical Approach For Retrograde Administration of Cardioplegic Solutions
1989
Myocardial protection via the coronary sinus is now currently used by several groups. Although it has generally provided satisfactory results, some of its problems are still not completely resolved. We present a new technique of cardioplegia delivery through the coronary sinus with a Pezzer catheter inserted into it and secured in place by a purse string suture. We believe that this method is safer and more reliable than others.
Physicochemical compatibility and stability of nebulizable drug admixtures containing Dornase alfa and tobramycin.
2012
The objective of this in-vitro study was to determine whether admixtures of the inhalation solutions Pulmozyme(®) (Dornase alfa) and either Bramitob(®) or Tobi(®) (both containing Tobramycin) are physicochemically compatible and to analyze the aerodynamic parameters of these admixtures. After mixing, test solutions were stored at room temperature and under ambient light conditions over a period of 24 h. Tobramycin concentrations were determined by using a fluorescence immunoassay. Stability of dornase alfa was determined by size-exclusion high performance liquid chromatography, ultraviolet spectroscopy, sodium dodecyl sulfate polyacrylamide gel electrophoresis and tentacle strong cation-exc…
Which factors affect the choice of the inhaler in chronic obstructive respiratory diseases?
2015
Inhalation is the preferred route of drug administration in chronic respiratory diseases because it optimises delivery of the active compounds to the targeted site and minimises side effects from systemic distribution. The choice of a device should be made after careful evaluation of the patient's clinical condition (degree of airway obstruction, comorbidities), as well as their ability to coordinate the inhalation manoeuvre and to generate sufficient inspiratory flow. These patient factors must be aligned with the specific advantages and limitations of each inhaler when making this important choice. Finally, adherence to treatment is not the responsibility of the patient alone, but should …
Symmetry for positive critical points of Caffarelli–Kohn–Nirenberg inequalities
2022
Abstract We consider positive critical points of Caffarelli–Kohn–Nirenberg inequalities and prove a Liouville type result which allows us to give a complete classification of the solutions in a certain range of parameters, providing a symmetry result for positive solutions. The governing operator is a weighted p -Laplace operator, which we consider for a general p ∈ ( 1 , d ) . For p = 2 , the symmetry breaking region for extremals of Caffarelli–Kohn–Nirenberg inequalities was completely characterized in Dolbeault et al. (2016). Our results extend this result to a general p and are optimal in some cases.
Multiple Solutions with Sign Information for a Class of Coercive (p, 2)-Equations
2019
We consider a nonlinear Dirichlet equation driven by the sum of a p-Laplacian and of a Laplacian (a (p, 2)-equation). The hypotheses on the reaction f(z, x) are minimal and make the energy (Euler) functional of the problem coercive. We prove two multiplicity theorems producing three and four nontrivial smooth solutions, respectively, all with sign information. We apply our multiplicity results to the particular case of a class of parametric (p, 2)-equations.
Characteristic numbers of non‐autonomous emden‐fowler type equations
2006
We consider the Emden‐Fowler equation x” = ‐q(t)|x|2εx, ε > 0, in the interval [a,b]. The coefficient q(t) is a positive valued continuous function. The Nehari characteristic number An associated with the Emden‐Fowler equation coincides with a minimal value of the functional [] over all solutions of the boundary value problem x” = ‐q(t)|x|2εx, x(a) = x(b) = 0, x(t) has exactly (n ‐ 1) zeros in (a, b). The respective solution is called the Nehari solution. We construct an example which shows that the Nehari extremal problem may have more than one solution. First Published Online: 14 Oct 2010
A DUALITY APPROACH TO THE FRACTIONAL LAPLACIAN WITH MEASURE DATA
2011
We describe a duality method to prove both existence and uniqueness of solutions to nonlocal problems like $$(-\Delta)^s v = \mu \quad \text{in } \mathbb{R}^N,$$ ¶ with vanishing conditions at infinity. Here $\mu$ is a bounded Radon measure whose support is compactly contained in $\mathbb{R}^N$, $N\geq2$, and $-(\Delta)^s$ is the fractional Laplace operator of order $s\in (1/2,1)$.
On the interior regularity of weak solutions to the 2-D incompressible Euler equations
2016
We study whether some of the non-physical properties observed for weak solutions of the incompressible Euler equations can be ruled out by studying the vorticity formulation. Our main contribution is in developing an interior regularity method in the spirit of De Giorgi–Nash–Moser, showing that local weak solutions are exponentially integrable, uniformly in time, under minimal integrability conditions. This is a Serrin-type interior regularity result $$\begin{aligned} u \in L_\mathrm{loc}^{2+\varepsilon }(\Omega _T) \implies \mathrm{local\ regularity} \end{aligned}$$ for weak solutions in the energy space $$L_t^\infty L_x^2$$ , satisfying appropriate vorticity estimates. We also obtain impr…