Search results for "Spinning"

Ocular Drug Delivery Systems per la veicolazione di molecole bioattive al segmento posteriore dell'occhio

Advanced electrospun matrices based on polysaccharide derivatives for applications in regenerative medicine

2021

The complete regeneration of damaged human tissues and organs is still a significant challenge. The integrative use of biomaterials, cells and bioactive factors in all-in-one devices exploits all current knowledge of materials science, nanotechnology and stem cell biology to best mimic the complex hierarchical architecture of native tissues. The artificial microenvironment design must be properly tuned to match the physicochemical features of the target, offering adequate nanoscale patterns and biological domains for cellular interactions. Scaffolds must promote and guide the regeneration route by mimicking host signalling pathways through the controlled release and retention of drugs or gr…

Microfibers obtained by electrospinning of alpha, beta poly(N-2-hydroxyethyl)-DL-aspartamide-g-polylactic acid for potential use in tissue reconstruc…

2009

A hyaluronic acid derivative as a coating film for an electrospun cell releasing system in the treatment of corneal wounds

2017

The transparency of the cornea is maintained by the stem cells of the corneal epithelium in the limbal region; damage to the limbus may cause partial or total limbal stem cell deficiency that, may lead to blindness. The transplantation of cells is crucial to regenerate the damaged areas. The techniques currently employed consist in cadaveric corneal transplantation or in the use of amniotic membrane as a carrier for delivering cultured limbal stem cells to the cornea. Both these approaches show severe drawbacks such as the potential reject of the transplanted cornea and the risk of viral disease transmissions. Here we report the production of an electrospun device that could be exploited as…

Heparin functionalized polyaspartamide/polyester scaffold for potential blood vessel regeneration

2013

Wet electrospinning-aided self-assembly of multifunctional GO-CNT@PCL core-shell nanocomposites with spider leg bioinspired hierarchical architectures

2022

We report a fast route enabling the multiscale design of nanohybrid structures comprising a 3D fibrous network of polycaprolactone (PCL) wrapped by graphene oxide (GO) sheets onto which carbon nanotube (CNT) brushes are anchored. The method relies on electrospinning PCL solutions onto a suspension of GO and CNTs in ethanol. Self-assembly is due to electrostatic wrapping of GO sheets around PCL fibers and 7C-7C stacking between GO and CNTs. Hierarchical architecture and nanopatterned surface allow gathering the starting properties of PCL, GO and CNTs into lightweight (99% porosity) yet robust (1575% stiffness improvement), amphiphilic monoliths that can remove methylene blue and/or methyl or…

An innovative route to prepare in situ graded crosslinked PVA graphene electrospun mats for drug release

2022

We present a fast, one step method to obtain PVA/graphene/chlorhexidine nanofibrous membranes, with a crosslinking gradient along their cross-section. Briefly, polymeric solutions were electrospun onto a heated plate, enabling the in situ crosslinking of PVA macromolecules. Of course, the crosslinking degree of such structures was found to decrease upon the distance from the plate during deposition. The outcomes reveal the crucial role of graphene, capable of promoting heat transfer throughout the entire structure, thus leading to 70-80% crosslinking degrees and preventing delamination issues. Such membranes were compared to untreated and oven thermally treated ones, and a robust relationsh…

Physical and antibacterial properties of PLA electrospun mats loaded with carvacrol and nisin

2022

Functional, biopolymeric electrospun structures for the controlled release of antimicrobial agents are gaining in-creasing interest in food packaging applications. In this study, the physical and antibacterial performances of ternary systems composed of polylactic acid (PLA) electrospun mats loaded with 20 wt% of different relative amounts of carvacrol (CRV) and a commercial nisin formulation (Nis) were assessed. Scanning electron micrographs displayed micro-scaled fibers with different diameter size distributions depending on the relative concentrations of the additives. The PLA/CRV/Nis membranes??? wettability was affected by the relative amount of CRV and Nis loaded, switching from hydro…

Physical and biological properties of electrospun poly(d,l‐lactide)/nanoclay and poly(d,l‐lactide)/nanosilica nanofibrous scaffold for bone tissue en…

2021

Abstract Electrospun scaffolds exhibiting high physical performances with the ability to support cell attachment and proliferation are attracting more and more scientific interest for tissue engineering applications. The inclusion of inorganic nanoparticles such as nanosilica and nanoclay into electrospun biopolymeric matrices can meet these challenging requirements. The silica and clay incorporation into polymeric nanofibers has been reported to enhance and improve the mechanical properties as well as the osteogenic properties of the scaffolds. In this work, for the first time, the physical and biological properties of polylactic acid (PLA) electrospun mats filled with different concentrat…

Biocompatibility and biodegradability of electrospun phea-pla scaffolds: Our preliminary experience in a murine animal model

2012

We obtained a nano-fibrillar scaffold starting from a polymeric solution which, through electrospinning, gave a biodegradable material with optimal mechanical features and the capacity to allow cell adhesion. In this paper we report the in-vivo application on a murine animal model of two electrospun biodegradable materials, specifically designed to create tubular structures. In one case PHEA-PLA was co-spun with silk fibroin (Fibro-PHEAPLA) by a parallel electrospinning process to obtain a scaffold with two different polymeric fibers. In the other case, PHEA-PLA was mixed with polycaprolactone (PCLPHEA-PLA) to obtain a hybrid fibers scaffold. The in-vitro assay showed fibroblast colonizatio…