Search results for "Spray-drying"

showing 4 items of 14 documents

Multicomponent solid dispersion a new generation of solid dispersion produced by spray-drying

2020

Abstract The term “multicomponent solid dispersion” is widely used in recent literature to describe solid formulations consisting of a special excipient's mixture and active molecules finely dispersed. However, this term has not yet been defined. In this review, we aimed to improve the definition of multicomponent solid dispersions as a new generation of solid dispersions capable to improve both formulation issues and the therapeutic effect of the final dosage form. As it is well-known the use of solid dispersions to improve drug dissolution rate and solubility, this review describes the field of solid dispersions as well as the formulation strategies available for their production. In part…

chemistry.chemical_classificationMaterials sciencePharmaceutical ScienceExcipient02 engineering and technologyPolymer021001 nanoscience & nanotechnology030226 pharmacology & pharmacyDosage form03 medical and health sciences0302 clinical medicineChemical engineeringchemistrySpray dryingmedicineDissolution testingSolubility0210 nano-technologyDispersion (chemistry)Multicomponent solid dispersion Spray-drying Dissolution rates Dosage form Polymersmedicine.drugJournal of Drug Delivery Science and Technology
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Spray-Dried Cytisine-Loaded Matrices: Development of Transbuccal Sustained-Release Tablets as a Promising Tool in Smoking Cessation Therapy

2022

Cytisine (CYT) has emerged as a promising molecule to treat nicotine addiction, since it acts as a partial agonist of nicotinic acetylcholine receptors. However, its unfavorable pharmacokinetic properties lead to multiple administrations per day, reducing the patient’s compliance and increasing the side effects. To overcome these drawbacks, CYT buccal administration is here proposed. Firstly, CYT stability in the buccal environment was assessed and its intrinsic ability to permeate/penetrate the tissue was determined by applying CYT solutions at increasing concentrations. Furthermore, a spray-drying method was selected and optimized as it is an eco-friendly, easily scalable and effective te…

cytisine; mucosal permeability; smoking cessation therapy; spray-drying; buccal tabletssmoking cessation therapySettore CHIM/09 - Farmaceutico Tecnologico Applicativocytisinemucosal permeabilityPharmaceutical Sciencespray-dryingbuccal tabletsPharmaceutics
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Encapsulation of Vitamins A and E as Spray-Dried Additives for the Feed Industry

2020

Encapsulated fat-soluble powders containing vitamin A (VA) and E (VE) were prepared as a feasible additive for extruded feed products. The effect of the encapsulating agents (Capsul-CAP&reg

medicine.medical_treatmentPharmaceutical Science02 engineering and technologyAnalytical Chemistrychemistry.chemical_compoundSpectroscopy Fourier Transform InfraredDrug DiscoveryVitamin E03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edadesVitamin ACalorimetry Differential ScanningTemperatureSpray Drying04 agricultural and veterinary sciences021001 nanoscience & nanotechnologyMaltodextrin040401 food science02.- Poner fin al hambre conseguir la seguridad alimentaria y una mejor nutrición y promover la agricultura sostenibleChemistry (miscellaneous)Spray dryingThermogravimetryMAQUINAS Y MOTORES TERMICOSMolecular MedicineEmulsionsExtrusionPowders0210 nano-technologyOxidation-ReductionPorosityMaterials scienceNanoemulsionsDrug CompoundingSodiumChemical structureSpray-dryingchemistry.chemical_elementArticle14.- Conservar y utilizar de forma sostenible los océanos mares y recursos marinos para lograr el desarrollo sosteniblelcsh:QD241-4410404 agricultural biotechnologylcsh:Organic chemistrymedicineThermal stabilityParticle SizePhysical and Theoretical ChemistryPorosityVitamin EOrganic ChemistryHumidityChemical engineeringchemistryDietary SupplementsNanoparticlesEncapsulationMolecules
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Optimization of Spray-Drying Process of

2019

Jerusalem artichoke is an important natural matrix for inulin production. In this experiment, response surface methodology (RSM) was employed to optimize the spray-drying parameters in order to determine the maximal inulin yield. For this study, three independent variables (heating temperature (Tª, 110–120 °C), creep speed (V, 18–22 rpm) and pressure (P, 0.02–0.04 MPa)) were used in the experimental design. Using the Box–Behnken design, the optimal parameters obtained were: drying temperature 114.6 °C, creep speed 20.02 rpm, and pressure: 0.03 MPa. The inulin yield, water content and particle size of inulin obtained by spray-drying and freeze-drying were compared. In this regard, the spray-…

response surface methodologyFreeze DryinginulinPlant ExtractsChemistry PharmaceuticalJerusalem artichokeHelianthusspray-dryingPowdersArticleMolecules (Basel, Switzerland)
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