Search results for "Sst"
showing 10 items of 538 documents
Latvijas Universitātes 95 mirkļi
2014
Latvijas Universitātes 95. gadadienai veltīts izdevums. -- The edition dedicated to the 95th anniversary of the University of Latvia
The Role of Autophagy and Apoptosis During Embryo Development
2015
Programmed cell death (PCD) and cell survival are two sides of the same coin. Autopha‐ gy and apoptosis are crucial processes during embryo development of Invertebrates and Vertebrates organisms, as they are necessary for the formation of a new organism, start‐ ing from a fertilized egg. Fertilization triggers cell remodeling from each gamete to a toti‐ potent zygote. During embryogenesis, the cells undergo various processes, thus allowing the transformation of the embryo into an adult organism. In particular, cells require the appropriate tools to suddenly modify their morphology and protein content in order to respond to intrinsic and external stimuli. Autophagy and apoptosis are involved…
From matrix clause to discourse marker: the grammaticalization of Hauptsache
2021
[EN] This paper has a double purpose. On the one hand, it intends to prove the existence of a discourse marker (DM) Hauptsache. This element preserves the core conceptual meaning of the homonymous noun, but differs from it with regard to its morphosyntactic and semantic features as well as to its discourse-organizing, information structuring, and modal functions. On the other hand, the emergence of Hauptsache as a discourse particle is explained on the grounds of a grammaticalization process similar to the ones described for the prototypical German DMs. Evidence drawn from a corpus of German and Austrian parliamentary protocols will show in which ways the six fundamental processes implied i…
In vitro vēža šūnu modeļsistēmas izstrāde molekulāri mērķētu radionuklīdu testēšanai
2019
Prostatas vēzis ir ceturtais biežāk diagnosticētais vēzis Eiropā, 2018. gadā un tas ir kļuvis par visbiežāk sastopamo vēzi vīriešu vidū. Nozīmīgi klīnisko pētījumu rezultāti prostatas vēža diagnostikā un terapijā ir sasniegti ar radioaktīvi iezīmētu PSMA ligandu 68Ga-PSMA – diagnostikai un 177Lu-PSMA – terapijai. Neiroendokrīnie audzēji ir neviendabīga agresīvu audzēju grupa, kam raksturīgi dažādi un bieži nespecifiski simptomi, kas apgrūtina precīzu audzēja primāro diagnostiku un saslimšanas stadijas precizēšanu. Pašlaik šo audzēju diagnostikā un ārstēšanā izmanto ar SSTR2 ligandiem (somatostatīna analogiem) konjugētus radionuklīdus. Šī darba mērķis bija izveidot uz dažādām šūnu līnijām ba…
Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase
2016
Heparanase is a β-d-glucuronidase which cleaves heparan sulfate chains in the extracellular matrix and on cellular membranes. A dysregulated heparanase activity is intimately associated with cell invasion, tumor metastasis and angiogenesis, making heparanase an attractive target for the development of anticancer therapies. SST0001 (roneparstat; Sigma-Tau Research Switzerland S.A.) is a non-anticoagulant 100% N-acetylated and glycol-split heparin acting as a potent heparanase inhibitor, currently in phase I in advanced multiple myeloma. Herein, the kinetics of heparanase inhibition by roneparstat is reported. The analysis of dose-inhibition curves confirmed the high potency of roneparstat (I…
Photomagnetism of Molecular Systems
2001
This article reviews various classes of transition metal compounds which display in the solid state light sensitive electronic structure modifications accompanied by drastic changes of their magnetic and/or optical properties, i.e., photomagnetism. Selected examples from this rapidly expanding field, include spin crossover, stilbenoid and nitrosyl complexes, as well as Prussian blue analogues.
Long range rapidity correlations and the ridge in A+A collisions
2009
We discuss results for n-gluon correlations that form the basis of the Glasma flux tube picture of early times in heavy ion collisions. Our formalism is valid to all orders in perturbation theory at leading logarithmic accuracy in x and includes both QCD bremsstrahlung and the many body screening and recombination effects that are important at large parton densities. Long range rapidity correlations, as seen in the near-side ridge in heavy ion collisions, are a chronometer of these early time strong color field dynamics. They also contain information on how radial flow develops in heavy ion collisions.
Direct photon production in Pb–Pb collisions atsNN=2.76 TeV
2016
Direct photon production at mid-rapidity in Pb–Pb collisions at √sNN = 2.76 TeV was studied in the transverse momentum range 0.9<pT<14 GeV/c. Photons were detected with the highly segmented electromagnetic calorimeter PHOS and via conversions in the ALICE detector material with the e+e− pair reconstructed in the central tracking system. The results of the two methods were combined and direct photon spectra were measured for the 0–20%, 20–40%, and 40–80% centrality classes. For all three classes, agreement was found with perturbative QCD calculations for pT≳5 GeV/c. Direct photon spectra down to pT≈1 GeV/c could be extracted for the 20–40% and 0–20% centrality classes. The significance of th…
Study of intrinsic energy dependence of α-alanine and dose intercomparison with ESR and ISE techniques
1993
Abstract The intrinsic energy behavior of the radiation chemical yields G(R·) and G(NH3) which determine the dose response for the alanine/ESR and alanine/Ion-Selective Electrode (ISE) system, is an important characteristic for the consistent use in different radiation environments. Therefore, the response of ISS and Gent α-alanine dosimeters in the dose range 0.1 to 700 kGy was examined with 60Co, bremsstrahlung and electron beam radiation. Bremsstrahlung beams with end point energy between 5 and 12 MeV and electron beams with mean energy at the effective point of measurement between 4 and 25 MeV were used. Analysis of the 60Co calibration results shows that there are no significant differ…
Gares exurbanisées et développement urbain : Le cas des gares TGV bourguignonnes
2009
Dès la mise en service de la ligne TGV Sud-Est, au début des années 80, la Bourgogne a bénéficié de la création de deux nouvelles gares TGV, aménagées en périphérie des pôles urbains du Creusot et de Mâcon. Malgré leurs fonctions réduites, ces nouvelles gares périurbaines ont suscité d’ambitieux projets d’aménagement. De nouvelles zones d’activités ont ainsi vu le jour à proximité de ces gares. Ces projets n’ont eu toutefois que des retombées limitées en matière d’implantation d’activités économiques. Since the opening of TGV south-east railway line at the beginning of the 80s Bourgogne has profited by construction of two new stations beyond the edge of Le Creusot and Mâcon. Despite their l…