Search results for "Sst"

BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians

2020

B-Cell Lymphoma-extra-large (BCL-xL) is involved in longevity and successful aging, which indicates a role for BCL-xL in cell survival pathway regulation. Beyond its well described role as an inhibitor of apoptosis by preventing cytochrome c release, BCL-xL has also been related, indirectly, to autophagy and senescence pathways. Although in these latter cases, BCL-xL has dual roles, either activating or inhibiting, depending on the cell type and the specific conditions. Taken together, all these findings suggest a precise mechanism of action for BCL-xL, able to regulate the crosstalk between apoptosis, autophagy, and senescence, thus promoting cell survival or cell death. All three pathways…

The value proposition of food delivery apps from the perspective of theory of consumption value

2021

Purpose The theory of consumption values (TCV) has successfully explained much consumer choice behavior, but few studies have investigated the values that drive food-delivery application (FDA) use. This study aims to bridge this gap by extending the TCV to the FDA context to examine food consumption-related values and interpreting and rechristening generic consumption values to adapt the TCV to the FDA context. Design/methodology/approach An explorative mixed-method research approach was taken to conduct focus group discussions with 20 target users to develop the questionnaire and then administer it for a cross-sectional survey (pen and pencil) to FDA users aged 22–65 years; 423 complete r…

Documento di consenso ANMCO/ELAS/SIBioC: Raccomandazioni sull'impiego dei biomarcatori cardiaci nello scompenso cardiaco

2016

Biomarkers have dramatically impacted the way heart failure (HF) patients are evaluated and managed. A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biological or pathogenic processes, or pharmacological responses to a therapeutic intervention. Natriuretic peptides (B-type natriuretic peptide [BNP] and N-terminal proBNP) are the gold standard biomarkers in determining the diagnosis and prognosis of HF, and a natriuretic peptide-guided HF management looks promising. In the last few years, an array of additional biomarkers has emerged, each reflecting different pathophysiological processes in the development and progression of HF: myocardia…

CFD prediction of flow, heat and mass transfer in woven spacer-filled channels for membrane processes

2021

Abstract Flow and heat or mass transfer in channels provided with woven spacers made up of mutually orthogonal filaments were studied by Computational Fluid Dynamics. The problem addressed was the combined effect of the parameters that characterize the process: pitch to height ratio P/H (2, 3 and 4), flow attack angle θ (0, 7, 15, 20, 30, 40 and 45°) and Reynolds number Re (from ~1 to ~4000). The Prandtl number was 4.33, representative of water at ~40°C, while the Schmidt number was 600, representative of NaCl solutions. Simulations were performed by the finite volume code Ansys CFX™ 18.1 using very fine grids of ~6 to ~14 million volumes. For Re > ~400, the SST turbulence model was used to…

Coexistence between IEEE802.15.4 and IEEE802.11 through cross-technology signaling

2017

When different technologies use the same frequency bands in close proximity, the resulting interference typically results in performance degradation. Coexistence methods exist, but these are often technology specific and requiring technology specific interference detection methods. To remove the root cause of the performance degradation, devices should be able to negotiate medium access even when using different technologies. To this end, this paper proposes an architecture that allows crosstechnology medium access by means of a Time Division Multiple Access (TDMA) scheme. In order to achieve cross-technology synchronization, which is required for the TDMA solution, an energy pattern beacon…

Vittorio Emanuele Orlando. Il giurista, l’avvocato, lo statista

2018

Vittorio Emanuele Orlando is one of the defining figures of the history of Italy. Lawyer, jurist and statesman, he founded the Italian School of Public Law and worked out an original version of the “Rechtsstaat”. He led Italy to victory during the First World War, took then an official stance against the Fascism and played a significant role in the republican constituent process. The article suggests a coherent interpretation of the several aspects of his personality and provides an extensive bibliography

Una crisi annunciata. Aporie e incrinature dello Stato liberale di diritto

2012

Negli stessi anni in cui la giuspubblicistica tedesca metteva a punto in chiave monistica la nozione di Rechtsstaat, la società si andava risistemando secondo moduli organizzativi e statuti complessi, rinnovando il suo carico di contraddizioni, differenziazioni, spinte aggregative e tendenze autonomistiche. La rassicurante immagine di uno Stato-persona in grado di neutralizzare mediante il suo diritto le tendenze centrifughe e di dissolvere nella sua unità politica le particolarità frazionali strideva con l’articolazione complessa e pluralistica della società industriale, con una realtà che non era formata da individui astratti, eguali e indifferenziati, ma da soggetti concreti, diseguali e…

La semplicità immaginaria. Apogeo e crisi dello Stato liberale di diritto.

2011

Teātra sports kā personību attīstoša ārpusstundu aktivitāte skolēniem

2015

Pētījuma mērķis ir noskaidrot, kādas prasmes skolēni iegūst un attīsta teātra sporta nodarbībās, kā arī noskaidrot skolēnu motivāciju. Bakalaura darbā tiek izklāstīta teātra sporta vēsture Latvijā. Tiek izskaidrota teātra sporta būtība, to veidojošie elementi, kā arī tiek izskaidrots, kā šī teatrālā aktivitāte ir saistīta ar sportu. Tiek aplūkotas motivācijas teorijas, kas izskaidro skolēnu vēlmi iesaistīties ārpusstundu aktivitātēs. Ērvinga Gofmaņa dramaturģiskā skaidro komandas darba nozīmīgumu teātra sportā. Pētījumā tika izmantotas divas pētnieciskās metodes – anketēšana un intervēšana. Darba empīrijas daļā tiek plašāk tiek aplūkotas prasmes un spējas, ko šī ārpusstundu aktivitāte attīs…

Programs' Efficacy to Develop Employable Skills for People With Functional Diversity: A Meta-Analysis

2021

Purpose: Promoting the labour integration of people with functional diversity is a key element to achieve their social inclusion. This meta-analysis aims to examine the effectiveness of experimental programs in developing employable skills for people with disabilities. Methods: Literature searches up to June 2019 were conducted in four databases (Web of Science, Scopus, PsycINFO and ERIC). Studies that met the following criteria were selected: (1) The program should develop employable skills; (2) the participants should be people with functional diversity; (3) the study should have a design with an experimental group and a control group as well as pretest and posttest measurements; (4) the …