Search results for "Stability"

Long-Term Reward Patterns Contribute to Personal Goals at Work Among Finnish Managers

2016

The research addresses the impact of long-term reward patterns on contents of personal work goals among young Finnish managers ( N = 747). Reward patterns were formed on the basis of perceived and objective career rewards (i.e., career stability and promotions) across four measurements (years 2006–2012). Goals were measured in 2012 and classified into categories of competence, progression, well-being, job change, job security, organization, and financial goals. The factor mixture analysis identified a three-class solution as the best model of reward patterns: high rewards (77%), increasing rewards (17%), and reducing rewards (7%). Participants with reducing rewards reported more progressio…

Stability and change model of job resources and work engagement: A seven-year three-wave follow-up study

2015

Using the stability and change model, conservation of resources theory and the job demands-resources model, this study aimed to determine: (1) the extent to which work engagement and job resources can be explained by a component reflecting stability and a component reflecting change in these constructs, and (2) the strength and direction of the relationship between work engagement and job resources when their stable components are controlled for. The study was carried out among 1,964 Finnish dentists over a seven-year time period (2003–2010), using a three-wave dataset. Some of the dentists had changed jobs during the follow-up, and therefore the research questions were validated among grou…

Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis

2011

Heat shock proteins (HSPs) are necessary for cancer cell survival. We identified a mutant of HSP110 (HSP110ΔE9) in colorectal cancer showing microsatellite instability (MSI CRC), generated from an aberrantly spliced mRNA and lacking the HSP110 substrate-binding domain. This mutant was expressed at variable levels in almost all MSI CRC cell lines and primary tumors tested. HSP110ΔE9 impaired both the normal cellular localization of HSP110 and its interaction with other HSPs, thus abrogating the chaperone activity and antiapoptotic function of HSP110 in a dominant-negative manner. HSP110ΔE9 overexpression caused the sensitization of cells to anticancer agents such as oxaliplatin and 5-fluorou…

Muscle activation during push-ups performed under stable and unstable conditions

2015

Background/Objective: The purpose of this study was to analyze muscle activation when performing push-ups under different stability conditions. Methods: Physically fit young male university students (N = 30) performed five push-ups under stable conditions (on the floor) and using four unstable devices (wobble board, stability disc, fitness dome, and the TRX Suspension Trainer). The push-up speed was controlled using a metronome, and the testing order was randomized. The average amplitudes of the electromyographic (EMG) root mean square of the anterior deltoid (DELT), serratus anterior (SERRA), lumbar multifidus (LUMB), and rectus femoris (FEM) were recorded. The electromyographic signals we…

Multiperiodic pulsations in the Be stars NW Serpentis and V1446 Aquilae

2007

Aims.We present accurate photometric time series of two Be stars: NW Ser and V1446 Aql . Both stars were observed at the Observatorio de Sierra Nevada (Granada) in July 2003 with an automatic four-channel Strömgren photometer. We also present a preliminary theoretical study showing that the periodic variations exhibited by these stars can be due to pulsation. Methods.An exhaustive Fourier analysis together with a least-square fitting has been carried out on the time series for all four Strömgren bands. Several independent frequencies and non-periodic trends explain most of the variance. A theoretical non-adiabatic code applied to stellar models for these stars shows that g-modes are unstabl…

Nonsense-mediated mRNA decay controls the changes in yeast ribosomal protein pre-mRNAs levels upon osmotic stress.

2013

The expression of ribosomal protein (RP) genes requires a substantial part of cellular transcription, processing and translation resources. Thus, the RP expression must be tightly regulated in response to conditions that compromise cell survival. In Saccharomyces cerevisiae cells, regulation of the RP gene expression at the transcriptional, mature mRNA stability and translational levels during the response to osmotic stress has been reported. Reprogramming global protein synthesis upon osmotic shock includes the movement of ribosomes from RP transcripts to stress-induced mRNAs. Using tiling arrays, we show that osmotic stress yields a drop in the levels of RP pre-mRNAs in S. cerevisiae cell…

2014

This paper is concerned with the problem of general output feedback stabilization for fractional order linear time-invariant (FO-LTI) systems with the fractional commensurate order0<α<2. The objective is to design suitable output feedback controllers that guarantee the stability of the resulting closed-loop systems. Based on the slack variable method and our previous stability criteria, some new results in the form of linear matrix inequality (LMI) are developed to the static and dynamic output feedback controllers synthesis for the FO-LTI system with0<α<1. Furthermore, the results are extended to stabilize the FO-LTI systems with1≤α<2. Finally, robust output feedback control…

A solution study of complex formation between iron(III) and oxalate in dimethylsulphoxide

1991

The complex formation between iron(III) and oxalic acid (ethanedioic acid, H2ox) has been studied by potentiometry in dimethylsulphoxide (dmso) solution. H2ox behaves as a weak diprotic acid in such a solvent, with overall association constants: log βj1=8.551(3) and log βj2=14.242(3) at 25°C and 0.1 Mn-Bu4NClO4. A reliable set of overall stability constants for the iron(III)-oxalato complexes, log β11=13.16(4), log β12=23.66(4) and log β13=30.75(4), have been obtained for the first time under identical conditions. The electrochemical behaviour of such complexes was studied in dmso at a platinum electrode. The coordination ability of oxalate towards iron(III) in dmso and water media is compa…

Ab initio study of phase competition in (La1−c,Src)CoO3 solid solutions

2013

Abstract (La 1 − c ,Sr c )CoO 3 (LSC) solid solutions are promising materials for high temperature electrochemical cells and cathodes of solid oxide fuel cells. The Density Functional Theory (DFT) was applied to calculate the energies of the different superstructures in LSC which are stable with respect to formation of anti-phase domains. The energy parameters determining the relative stability of the cubic superstructures (phases) are extracted from these calculations. Using the Concentration Wave formalism and the energy parameters for different phases from DFT calculations, the temperature dependences of the long-range order parameters were obtained characterizing the order–disorder tran…

C172S Substitution in the Chloroplast-encoded Large Subunit Affects Stability and Stress-induced Turnover of Ribulose-1,5-bisphosphate Carboxylase/Ox…

1999

Previous work has indicated that the turnover of chloroplast ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco; EC 4.1.1. 39) may be controlled by the redox state of certain cysteine residues. To test this hypothesis, directed mutagenesis and chloroplast transformation were employed to create a C172S substitution in the Rubisco large subunit of the green alga Chlamydomonas reinhardtii. The C172S mutant strain was not substantially different from the wild type with respect to growth rate, and the purified mutant enzyme had a normal circular dichroism spectrum. However, the mutant enzyme was inactivated faster than the wild-type enzyme at 40 and 50 degrees C. In contrast, C172S mutant …