Search results for "Static"

Fracture mechanics of snow avalanches.

2001

Dense snow avalanches are analyzed by modeling the snow slab as an elastic and brittle plate, attached by static friction to the underlying ground. The grade of heterogeneity in the local fracture (slip) thresholds, and the ratio of the average substrate slip threshold to the average slab fracture threshold, are the decisive parameters for avalanche dynamics. For a strong pack of snow there appears a stable precursor of local slips when the frictional contacts are weakened (equivalent to rising temperature), which eventually trigger a catastrophic crack growth that suddenly releases the entire slab. In the opposite limit of very high slip thresholds, the slab simply melts when the temperatu…

Zinc-blende AlN and GaN under pressure: structural, electronic, elastic and piezoelectric properties

2004

In this paper we report a theoretical study of the structural, elastic, electronic and piezoelectric properties of zinc-blende AlN and GaN under the pressure effect. The study is focused on the first-principles all electron full-potential augmented plane wave plus local orbitals calculations within the density-functional theory. The results of bulk properties, including lattice constants, bulk modulus and derivatives and band structures are obtained and compared using both the local density approximation (LDA) and the generalized gradient approximation (GGA) for the exchange-correlation functional. We find that the GGA does not give a significant improvement over LDA. We also report calcula…

High-pressure structural study of the scheelite tungstatesCaWO4andSrWO4

2005

Angle-dispersive x-ray-diffraction and x-ray-absorption near-edge structure measurements have been performed on ${\mathrm{CaWO}}_{4}$ and ${\mathrm{SrWO}}_{4}$ up to pressures of approximately 20 GPa. Both materials display similar behavior in the range of pressures investigated in our experiments. As in the previously reported case of ${\mathrm{CaWO}}_{4}$, under hydrostatic conditions ${\mathrm{SrWO}}_{4}$ undergoes a pressure-induced scheelite-to-fergusonite transition around 10 GPa. Our experimental results are compared to those found in the literature and are further supported by ab initio total-energy calculations, from which we also predict the instability at larger pressures of the …

Hsp60 and Hsp10 overexpression in metastatic colon cancer.

2006

Circulating cathepsin K and cystatin C in patients with cancer related bone disease: clinical and therapeutic implications.

2007

Abstract The clinical significance of serum cathepsin K and cystatin C was assessed in patients with breast cancer (BCa) or prostate cancer (PCa) with confined disease (M0) or bone metastasis (BM). Cathepsin K and cystatin C circulating levels were determined by ELISAs in 63 cancer patients, in 35 patients with nonmalignant diseases and in 42 healthy blood donors (control group). In BCa patients, cathepsin K serum levels were significantly lower than in sex matched control group (HS; p  = 0.0008) or in patients with primary osteoporosis (OP; p  = 0.0009). On the contrary, cystatin C levels were significantly higher in BCa patients than in HS ( p  = 0.0001) or OP ( p  = 0.017). In PCa patien…

APPROCCIO FARMACOLOGICO NEL PAZIENTE CON MALATTIA NON SUSCETTIBILE DI TERAPE LOCO-REGIONALI AD INTENTO CURATIVO.

2006

RUOLO DELL'HIFU NELLA TERAPIA DEL CARCINOMA PROSTATICO

2009

Measurement of brain tissue pressure in cold induced cerebral oedema.

1973

Experiments were performed in order to evaluate the concept that brain oedema is associated with an increase in local interstitial fluid pressure. Assuming that the pressure measured by the cotton wick technique represents the hydrostatic interstitial fluid pressure, the tissue pressure was recorded with pressure transducers in the white matter adjacent and remote to a local cold injury, in the opposite hemisphere, and in the cisterna magna. In 9 cats during steady-state conditions mean tissue pressures between 1.20±0.30 mm Hg and 2.33±0.80 mm Hg were found, as compared to a mean CSF pressure of 5.17±0.82 mm Hg. The tissue pressure was found to increase significantly adjacent to the lesion …

Non-pegylated liposomal doxorubicin plus cyclophosphamide as first-line therapy in elderly women with HER2 negative metastatic breast cancer.

2022

Background. The use of anthracyclines in metastatic breast cancer (MBC) is limited by cumulative dose-dependent cardiotoxicity mostly in elderly women with comorbidities. The aim of this observational retrospective study was to evaluate the efficacy of non-pegylated liposomal doxorubicin (Myocet®) and cyclophosphamide in elderly women as HER2 negative first-line MBC treatment. Methods. 84 elderly women >70 years of age (median age 78 years) with MBC HER2 negative were enrolled. Performance Status in 58 patients was ECOG-0 and in 26 patients was ECOG-1. Results. The drug was well tolerated, with overall response rates were >40%, median overall survival was 16.2 months (95%CI:14.6- 18.8…

Reversible Tuning of Ca Nanoparticles Embedded in a Superionic CaF2 Matrix

2019

Controlling the size and shape of metallic colloids is crucial for a number of nanotechnological applications ranging from medical diagnosis to electronics. Yet, achieving tunability of morphological changes at the nanoscale is technically difficult and the structural modifications made on nanoparticles generally are irreversible. Here, we present a simple nonchemical method for controlling the size of metallic colloids in a reversible manner. Our strategy consists of applying hydrostatic pressure on a Ca cationic sublattice embedded in the irradiated matrix of CaF2 containing a large concentration of defects. Application of our method to CaF2 along with in situ optical absorption of the Ca…