Search results for "Static"
showing 10 items of 1528 documents
Approximation of the Feasible Parameter Set in worst-case identification of Hammerstein models
2005
The estimation of the Feasible Parameter Set (FPS) for Hammerstein models in a worst-case setting is considered. A bounding procedure is determined both for polytopic and ellipsoidic uncertainties. It consists in the projection of the FPS of the extended parameter vector onto suitable subspaces and in the solution of convex optimization problems which provide Uncertainties Intervals of the model parameters. The bounds obtained are tighter than in the previous approaches. hes.
A non-hydrostatic pressure distribution solver for the nonlinear shallow water equations over irregular topography
2016
Abstract We extend a recently proposed 2D depth-integrated Finite Volume solver for the nonlinear shallow water equations with non-hydrostatic pressure distribution. The proposed model is aimed at simulating both nonlinear and dispersive shallow water processes. We split the total pressure into its hydrostatic and dynamic components and solve a hydrostatic problem and a non-hydrostatic problem sequentially, in the framework of a fractional time step procedure. The dispersive properties are achieved by incorporating the non-hydrostatic pressure component in the governing equations. The governing equations are the depth-integrated continuity equation and the depth-integrated momentum equation…
Solving dynamic memory allocation problems in embedded systems with parallel variable neighborhood search strategies
2015
International audience; Embedded systems have become an essential part of our lives, thanks to their evolution in the recent years, but the main drawback is their power consumption. This paper is focused on improving the memory allocation of embedded systems to reduce their power consumption. We propose a parallel variable neighborhood search algorithm for the dynamic memory allocation problem, and compare it with the state of the art. Computational results and statistical tests applied show that the proposed algorithm produces significantly better outcomes than the previous algorithm in shorter computing time.
Electrostatic backscattering by insulating obstacles
2012
AbstractWe introduce and analyze backscattering data for a three-dimensional obstacle problem in electrostatics. In particular, we investigate the asymptotic behavior of these data as (i) the measurement point goes to infinity and (ii) the obstacles shrink to individual points. We also provide numerical simulations of these data.
Programmable assembly of peptide amphiphile via noncovalent-to-covalent bond conversion
2017
Controlling the number of monomers in a supramolecular polymer has been a great challenge in programmable self-assembly of organic molecules. One approach has been to make use of frustrated growth of the supramolecular assembly by tuning the balance of attractive and repulsive intermolecular forces. We report here on the use of covalent bond formation among monomers, compensating for intermolecular electrostatic repulsion, as a mechanism to control the length of a supramolecular nanofiber formed by self-assembly of peptide amphiphiles. Circular dichroism spectroscopy in combination with dynamic light scattering, size-exclusion chromatography, and transmittance electron microscope analyses r…
The oral KIF11 inhibitor 4SC‐205 exhibits antitumor activity and potentiates standard and targeted therapies in primary and metastatic neuroblastoma …
2021
Inhibidor de KIF11; Terapias dirigidas; Metástasis Inhibidor de KIF11; Teràpies dirigides; Metàstasi KIF11 inhibitor; Targeted therapies; Metastasis In summary, our study provides a rationale for the future therapeutic integration in clinical trials of 4SC-205, an structurally distinct oral KIF11 inhibitor that shows potent antitumor activity in multiple preclinical neuroblastoma models and sensitizes neuroblastoma cells to standard chemotherapy and specific neuroblastoma-targeted therapies. The financial support for this research was provided by Instituto de Salud Calos III (PI20/00530 to Miguel F. Segura; PI20/01107 to Rosa Noguera; PI17/02248 and CPII18/00027 to Anna Santamaria; PI19/013…
Unusual case of dorsal vertebral metastases from a male breast cancer
2017
Introduction: Breast cancer is a malignant neoplasm arising from mammary glands and is a rare entity in the male patient. Spine is a common site for skeletal metastases. Case presentation: A 53-years-old male was admitted to our Neurosurgical unit because of an untreatable dorsal pain. He had been treated 3 years before for breast cancer. A dorsal Magnetic Resonance Imaging (MRI) evidenced pathological masses at T8 level. A total body Computed Tomography (CT) scan revealed lungs and liver metastases. After a multidisciplinary consult, a posterior T8 decompression, a radiofrequency thermoablation in T8 vertebral body followed by screws and rods fixation (T7-T9) was performed. Post-operative …
Influence of the Mediterranean Sea on the West African monsoon: Intraseasonal variability in numerical simulations
2010
[1] The influence of May to September sea surface temperature (SST) anomalies in the Mediterranean Sea on the West African monsoon is investigated, analyzing the outputs of numerical sensitivity experiments performed using three atmospheric general circulation models (Action de Recherche Petite Echelle Grande Echelle, European/Hamburg, and University of California, Los Angeles) in the framework of the African Monsoon Multidisciplinary Analysis project. The precipitation and atmospheric dynamics response to the SST forcing is explored, in terms of intraseasonal variability, evaluating the results from the individual models and from the multimodel mean. A positive precipitation response to wa…
MBCL-07. NON-METASTATIC MEDULLOBLASTOMA OF EARLY CHILDHOOD: RESULTS FROM THE PROSPECTIVE CLINICAL TRIAL HIT-2000 AND AN EXTENDED VALIDATION COHORT
2020
Abstract OBJECTIVE To avoid craniospinal irradiation (CSI) in children younger than four years with non-metastatic medulloblastoma by chemotherapy, intraventricular methotrexate and risk-adapted local radiotherapy. PATIENTS AND METHODS Eighty-seven patients received systemic chemotherapy and intraventricular methotrexate. Until 2006, CSI was reserved for non-response or progression. After 2006, local radiotherapy was introduced for non-responders or classic (CMB), anaplastic or large-cell medulloblastoma (LCA). Infantile SHH-activated medulloblastomas (SHH_INF) were subdivided by DNA-methylation profiling. Survival in SHH_INF subtypes were also assessed in a validation cohort (n=71). RESULT…
Characterization of Human γδ T Lymphocytes Infiltrating Primary Malignant Melanomas
2012
T lymphocytes are often induced naturally in melanoma patients and infiltrate tumors. Given that gamma delta T cells mediate antigen-specific killing of tumor cells, we studied the representation and the in vitro cytokine production and cytotoxic activity of tumor infiltrating gamma delta T cells from 74 patients with primary melanoma. We found that gamma delta T cells represent the major lymphocyte population infiltrating melanoma, and both V delta 1(+) and V delta 2(+) cells are involved. The majority of melanoma-infiltrating gamma delta cells showed effector memory and terminally-differentiated phenotypes and, accordingly, polyclonal gamma delta T cell lines obtained from tumor-infiltrat…