Search results for "Statistical Data"
showing 10 items of 15 documents
Identifying Prognostic SNPs in Clinical Cohorts: Complementing Univariate Analyses by Resampling and Multivariable Modeling
2016
Clinical cohorts with time-to-event endpoints are increasingly characterized by measurements of a number of single nucleotide polymorphisms that is by a magnitude larger than the number of measurements typically considered at the gene level. At the same time, the size of clinical cohorts often is still limited, calling for novel analysis strategies for identifying potentially prognostic SNPs that can help to better characterize disease processes. We propose such a strategy, drawing on univariate testing ideas from epidemiological case-controls studies on the one hand, and multivariable regression techniques as developed for gene expression data on the other hand. In particular, we focus on …
Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy
2017
Fasting reduces glucose levels and protects mice against chemotoxicity, yet drugs that promote hyperglycemia are widely used in cancer treatment. Here, we show that dexamethasone (Dexa) and rapamycin (Rapa), commonly administered to cancer patients, elevate glucose and sensitize cardiomyocytes and mice to the cancer drug doxorubicin (DXR). Such toxicity can be reversed by reducing circulating glucose levels by fasting or insulin. Furthermore, glucose injections alone reversed the fasting-dependent protection against DXR in mice, indicating that elevated glucose mediates, at least in part, the sensitizing effects of rapamycin and dexamethasone. In yeast, glucose activates protein kinase A (P…
The anisotropy of personal space.
2019
Violations of personal space are associated with discomfort. However, the exact function linking the magnitude of discomfort to interpersonal distance has not yet been specified. In this study, we explore whether interpersonal distance and discomfort are isotropic with respect to uncomfortably far or close distances. We also extend previous findings with regard to intrusions into personal space as well as maintenance of distances outside of personal space. We presented subjects with 15 interpersonal distances ranging from 40 to 250 cm and obtained verbal and joystick-based ratings of discomfort. Whereas discomfort rose immediately when personal space was entered, the gradient was less steep…
The Construct of Sexual Openness for Females in Steady Intimate Relationships
2017
The analysis of open-minded attitudes towards sexuality in general requires a construct based on attitudinal dimensions. Although several existing studies involve sexual attitudes, they differ substantially and standardized conceptual work is missing. Thus, the authors introduce the latent variable sexual openness to develop a construct based on self-oriented attitudes towards different sexual topics. Available survey data of female German students in a steady relationship allowed providing a first empirical test for the applicability of this construct. Five subdimensions are acknowledged central for sexual openness: sexual practices, masturbation, bisexuality, permissiveness, and pornograp…
Testing for goodness rather than lack of fit of continuous probability distributions.
2021
The vast majority of testing procedures presented in the literature as goodness-of-fit tests fail to accomplish what the term is promising. Actually, a significant result of such a test indicates that the true distribution underlying the data differs substantially from the assumed model, whereas the true objective is usually to establish that the model fits the data sufficiently well. Meeting that objective requires to carry out a testing procedure for a problem in which the statement that the deviations between model and true distribution are small, plays the role of the alternative hypothesis. Testing procedures of this kind, for which the term tests for equivalence has been coined in sta…
Descriptive Statistics
2009
A set of medical data is based on a collection of the data of individual cases or objects, also called observation units or statistical units. Every case, for example every study participant, patient, every experimental animal, every tooth or every cell shows comparable parameters (such as body weight, gender, erosion, pH). Each of these parameters, also called variables, has a specific parameter value (gender = male, age = 30 years, weight = 70 kg) for each observation unit (for example the patient). The aim of descriptive statistics is to summarize the data, so that they can be clearly illustrated (1–3). The property of a parameter is specified by its so-called scale of measure. Generally…
Polarization and suburbanisation in Warsaw
2001
The economic transition in Poland leads to a restructuration of economic activities which affects spatial patterns of cities, especially in Warsaw. Analyzing the location and re-location of population and employment in Poland’s capital allows to enlarge the debate on the suburbanization forms to the Central and Oriental European Countries. The results support the fact that the city center is still largely the most important district in terms of population andemployment, so that in 1999 the city keeps a strong monocentric character. However, from 1994 to 1999, population and employment move towards the Warsaw’s suburbs. Two significant observations, namely the suburbanization of retailing an…
Quantitative Characteristics of Information Society and ICT Industry in Latvia
2015
Abstract The article is devoted to statistical analysis of information and communication technology (ICT) industry in Latvia and the development of Information Society in the country. On the basis of statistical data comparison of Latvia with other European countries is made. This comparison shows that Latvia belongs to countries with very well developed Internet. On the other hand the statistical data points on the fact that it is necessary to increase the awareness of population regarding possibilities offered by using of ICT and e-Government.
Aspects of Statistics on Innovation in Latvia and Some Guidelines for Its Effective Use
2016
AbstractStatistical data on innovation in Latvia, at a current stage, were applied only to the particular areas of developing and planning of Latvian innovation support strategies. The aim of the paper is to show Latvian innovative performance and to provide proposals on making statistical data on innovations more useful for the analysis of innovativeness of Latvia. Research methods: bibliography review and methods of statistical analysis, such as processing and comparative analysis.
Epidemiology and Reporting Characteristics of Systematic Reviews of Biomedical Research: A Cross-Sectional Study.
2016
Background Systematic reviews (SRs) can help decision makers interpret the deluge of published biomedical literature. However, a SR may be of limited use if the methods used to conduct the SR are flawed, and reporting of the SR is incomplete. To our knowledge, since 2004 there has been no cross-sectional study of the prevalence, focus, and completeness of reporting of SRs across different specialties. Therefore, the aim of our study was to investigate the epidemiological and reporting characteristics of a more recent cross-section of SRs. Methods and Findings We searched MEDLINE to identify potentially eligible SRs indexed during the month of February 2014. Citations were screened using pre…