Search results for "Statistical"
showing 10 items of 4960 documents
Internal limiting membrane peeling versus no peeling during primary vitrectomy for rhegmatogenous retinal detachment: A systematic review and meta-an…
2018
Background Internal limiting membrane (ILM) peeling during primary vitrectomy for rhegmatogenous retinal detachment (RRD) prevents the formation of postoperative macular epiretinal membrane (ERM). However, studies that compared vitrectomy with and without ILM peeling for RRD, have reported controversial outcomes. Objective To assess the efficacy of ILM peeling versus non-ILM peeling during vitrectomy for RRD by a systematic review and meta-analysis of published studies. Methods PubMed, Medline, Web of Science, Embase databases, and the Cochrane Library were searched up to April 2018 to identify studies that compared primary vitrectomy with and without ILM peeling for RRD with at least six m…
Structural analyses of a hypothetical minimal metabolism
2007
By integrating data from comparative genomics and large-scale deletion studies, we previously proposed a minimal gene set comprising 206 protein-coding genes. To evaluate the consistency of the metabolism encoded by such a minimal genome, we have carried out a series of computational analyses. Firstly, the topology of the minimal metabolism was compared with that of the reconstructed networks from natural bacterial genomes. Secondly, the robustness of the metabolic network was evaluated by simulated mutagenesis and, finally, the stoichiometric consistency was assessed by automatically deriving the steady-state solutions from the reaction set. The results indicated that the proposed minimal …
Clonal Interference and the Evolution of RNA Viruses
1999
In asexual populations, beneficial mutations that occur in different lineages compete with one another. This phenomenon, known as clonal interference, ensures that those beneficial mutations that do achieve fixation are of large effect. Clonal interference also increases the time between fixations, thereby slowing the adaptation of asexual populations. The effects of clonal interference were measured in the asexual RNA virus vesicular stomatitis virus; rates and average effects of beneficial mutations were quantified.
Biostatistical basis of individualization and segregation analysis using the multilocus DNA probe MZ 1.3: results of a collaborative study.
1992
A collaborative study using the multilocus minisatellite DNA probe MZ 1.3 was carried out to investigate segregation information, mutation rate, DNA fragment frequencies as well as band sharing characteristics. The fingerprint patterns of 393 children as well as 694 unrelated individuals were analysed after digestion of DNA with the restriction enzyme HinfI. A mutation rate of 1% per meiosis or 0.04% per band was found with a mean number of 26 bands/individual. It was shown that maternal and paternal fragments are inherited in equal proportions. Population frequencies of restriction fragments demonstrated a distribution with increasing frequencies in the small fragment size range below 10 k…
Cis-epistasis at the LPA locus and risk of cardiovascular diseases.
2022
AIMS Coronary artery disease (CAD) has a strong genetic predisposition. However, despite substantial discoveries made by genome-wide association studies (GWAS), a large proportion of heritability awaits identification. Non-additive genetic-effects might be responsible for part of the unaccounted genetic variance. Here we attempted a proof-of-concept study to identify non-additive genetic effects, namely epistatic interactions, associated with CAD. METHODS AND RESULTS We tested for epistatic interactions in ten CAD case-control studies and UK Biobank with focus on 8,068 SNPs at 56 loci with known associations with CAD risk. We identified a SNP pair located in cis at the LPA locus, rs1800769 …
Inverted Repeats in Viral Genomes
2004
We investigate 738 complete genomes of viruses to detect the presence of short inverted repeats. The number of inverted repeats found is compared with the prediction obtained for a Bernoullian and for a Markovian control model. We find as a statistical regularity that the number of observed inverted repeats is often greater than the one expected in terms of a Bernoullian or Markovian model in several of the viruses and in almost all those with a genome longer than 30,000 bp.
Statistical properties of thermodynamically predicted RNA secondary structures in viral genomes
2008
By performing a comprehensive study on 1832 segments of 1212 complete genomes of viruses, we show that in viral genomes the hairpin structures of thermodynamically predicted RNA secondary structures are more abundant than expected under a simple random null hypothesis. The detected hairpin structures of RNA secondary structures are present both in coding and in noncoding regions for the four groups of viruses categorized as dsDNA, dsRNA, ssDNA and ssRNA. For all groups hairpin structures of RNA secondary structures are detected more frequently than expected for a random null hypothesis in noncoding rather than in coding regions. However, potential RNA secondary structures are also present i…
Recovery of time-dependent coefficients from boundary data for hyperbolic equations
2019
We study uniqueness of the recovery of a time-dependent magnetic vector-valued potential and an electric scalar-valued potential on a Riemannian manifold from the knowledge of the Dirichlet to Neumann map of a hyperbolic equation. The Cauchy data is observed on time-like parts of the space-time boundary and uniqueness is proved up to the natural gauge for the problem. The proof is based on Gaussian beams and inversion of the light ray transform on Lorentzian manifolds under the assumptions that the Lorentzian manifold is a product of a Riemannian manifold with a time interval and that the geodesic ray transform is invertible on the Riemannian manifold.
Intraseasonal rainfall variability over Madagascar
2016
International audience; Using daily rain-gauge records for Madagascar and nearby islands, this paper investigates rainfall intraseasonal variability at local and regional scales during the austral summer season (November–February), as well as the respective influences of recurrent convective regimes over the South-West Indian Ocean (SWIO) and the Madden-Julian Oscillation (MJO). Our results show a general consistency between local-scale rainfall variability in Madagascar and regional-scale features of climate variability. The influence of Tropical-Temperate Troughs in their mature phase and/or their easternmost locations is first underlined. The development of such systems over Southern Afr…
A methodological comparison of head-cut based gully erosion susceptibility models
2020
Abstract A GIS-based hybrid approach for gully erosion susceptibility mapping (GESM) in the Biarjamand watershed in Iran is presented. A database comprised of 15 geo-environmental factors (GEFs) was compiled and used to predict the spatial distribution of 358 gully locations; 70% (251) of which were extracted for training and 30% (107) for validation. A Dempster-Shafer (DS) statistical model was employed to map susceptibility. Next, the results of four kernels (binary logistic, reg logistic, binary logitraw, and reg linear) of a boosted regression tree (BRT) model were combined to increase the efficiency and accuracy of the mapping. Area under receiver operating characteristics (AUROC), tru…