6533b857fe1ef96bd12b5044

RESEARCH PRODUCT

Clonal Interference and the Evolution of RNA Viruses

Rosario MirallesSantiago F. ElenaAndrés MoyaPhilip J. Gerrish

subject

GeneticsLikelihood FunctionsModels StatisticalMultidisciplinaryGenes ViralbiologyClonal interferenceRNARNA virusVirus Replicationbiology.organism_classificationAdaptation PhysiologicalBiological EvolutionModels BiologicalVesicular stomatitis Indiana virusCell LineGene FrequencyVesicular stomatitis virusCricetinaeMutationConfidence IntervalsAnimals

description

In asexual populations, beneficial mutations that occur in different lineages compete with one another. This phenomenon, known as clonal interference, ensures that those beneficial mutations that do achieve fixation are of large effect. Clonal interference also increases the time between fixations, thereby slowing the adaptation of asexual populations. The effects of clonal interference were measured in the asexual RNA virus vesicular stomatitis virus; rates and average effects of beneficial mutations were quantified.

yearjournalcountryeditionlanguage
1999-09-10Science
https://doi.org/10.1126/science.285.5434.1745