Search results for "Statistical"
showing 10 items of 4960 documents
Adaptive linear rank tests for eQTL studies
2012
Expression quantitative trait loci (eQTL) studies are performed to identify single-nucleotide polymorphisms that modify average expression values of genes, proteins, or metabolites, depending on the genotype. As expression values are often not normally distributed, statistical methods for eQTL studies should be valid and powerful in these situations. Adaptive tests are promising alternatives to standard approaches, such as the analysis of variance or the Kruskal-Wallis test. In a two-stage procedure, skewness and tail length of the distributions are estimated and used to select one of several linear rank tests. In this study, we compare two adaptive tests that were proposed in the literatur…
A weighted combined effect measure for the analysis of a composite time-to-first-event endpoint with components of different clinical relevance
2018
Composite endpoints combine several events within a single variable, which increases the number of expected events and is thereby meant to increase the power. However, the interpretation of results can be difficult as the observed effect for the composite does not necessarily reflect the effects for the components, which may be of different magnitude or even point in adverse directions. Moreover, in clinical applications, the event types are often of different clinical relevance, which also complicates the interpretation of the composite effect. The common effect measure for composite endpoints is the all-cause hazard ratio, which gives equal weight to all events irrespective of their type …
Generating survival times to simulate Cox proportional hazards models
2005
Simulation studies present an important statistical tool to investigate the performance, properties and adequacy of statistical models in pre-specified situations. One of the most important statistical models in medical research is the proportional hazards model of Cox. In this paper, techniques to generate survival times for simulation studies regarding Cox proportional hazards models are presented. A general formula describing the relation between the hazard and the corresponding survival time of the Cox model is derived, which is useful in simulation studies. It is shown how the exponential, the Weibull and the Gompertz distribution can be applied to generate appropriate survival times f…
Using Statistical and Computer Models to Quantify Volcanic Hazards
2009
Risk assessment of rare natural hazards, such as large volcanic block and ash or pyroclastic flows, is addressed. Assessment is approached through a combination of computer modeling, statistical modeling, and extreme-event probability computation. A computer model of the natural hazard is used to provide the needed extrapolation to unseen parts of the hazard space. Statistical modeling of the available data is needed to determine the initializing distribution for exercising the computer model. In dealing with rare events, direct simulations involving the computer model are prohibitively expensive. The solution instead requires a combination of adaptive design of computer model approximation…
Statistically validated hierarchical clustering: Nested partitions in hierarchical trees
2022
We develop an algorithm that is fast and scalable in the detection of a nested partition extracted from a dendrogram that is obtained from hierarchical clustering of a multivariate series. Our algorithm provides a -value for each clade observed in the hierarchical tree. The -value is obtained by computing many bootstrap replicas of the dissimilarity matrix and by performing a statistical test on each difference between the dissimilarity associated with a given clade and the dissimilarity of the clade of its parent node. We prove the efficacy of our algorithm with a set of benchmarks generated by a hierarchically nested factor model. We compare results obtained by our algorithm with those of…
A form factor approach to the asymptotic behavior of correlation functions in critical models
2011
We propose a form factor approach for the computation of the large distance asymptotic behavior of correlation functions in quantum critical (integrable) models. In the large distance regime we reduce the summation over all excited states to one over the particle/hole excitations lying on the Fermi surface in the thermodynamic limit. We compute these sums, over the so-called critical form factors, exactly. Thus we obtain the leading large distance behavior of each oscillating harmonic of the correlation function asymptotic expansion, including the corresponding amplitudes. Our method is applicable to a wide variety of integrable models and yields precisely the results stemming from the Lutt…
Form factor approach to dynamical correlation functions in critical models
2012
We develop a form factor approach to the study of dynamical correlation functions of quantum integrable models in the critical regime. As an example, we consider the quantum non-linear Schr\"odinger model. We derive long-distance/long-time asymptotic behavior of various two-point functions of this model. We also compute edge exponents and amplitudes characterizing the power-law behavior of dynamical response functions on the particle/hole excitation thresholds. These last results confirm predictions based on the non-linear Luttinger liquid method. Our results rely on a first principles derivation, based on the microscopic analysis of the model, without invoking, at any stage, some correspon…
Thermal form factors of the XXZ chain and the large-distance asymptotics of its temperature dependent correlation functions
2013
We derive expressions for the form factors of the quantum transfer matrix of the spin-1/2 XXZ chain which are suitable for taking the infinite Trotter number limit. These form factors determine the finitely many amplitudes in the leading asymptotics of the finite-temperature correlation functions of the model. We consider form-factor expansions of the longitudinal and transversal two-point functions. Remarkably, the formulae for the amplitudes are in both cases of the same form. We also explain how to adapt our formulae to the description of ground state correlation functions of the finite chain. The usefulness of our novel formulae is demonstrated by working out explicit results in the hig…
Thermodynamic limit of particle-hole form factors in the massless XXZ Heisenberg chain
2010
We study the thermodynamic limit of the particle-hole form factors of the XXZ Heisenberg chain in the massless regime. We show that, in this limit, such form factors decrease as an explicitly computed power-law in the system-size. Moreover, the corresponding amplitudes can be obtained as a product of a "smooth" and a "discrete" part: the former depends continuously on the rapidities of the particles and holes, whereas the latter has an additional explicit dependence on the set of integer numbers that label each excited state in the associated logarithmic Bethe equations. We also show that special form factors corresponding to zero-energy excitations lying on the Fermi surface decrease as a …
Asymptotics of correlation functions of the Heisenberg-Ising chain in the easy-axis regime
2016
We analyze the long-time large-distance asymptotics of the longitudinal correlation functions of the Heisenberg-Ising chain in the easy-axis regime. We show that in this regime the leading asymptotics of the dynamical two-point functions is entirely determined by the two-spinon contribution to their form factor expansion. Its explicit form is obtained from a saddle-point analysis of the corresponding double integral. It describes the propagation of a wave front with velocity $v_{c_1}$ which is found to be the maximal possible group velocity. Like in wave propagation in dispersive media the wave front is preceded by a precursor running ahead with velocity $v_{c_2}$. As a special case we obta…