Search results for "Stein"
showing 10 items of 1448 documents
Landau‐Zener transition for association of an atomic Bose‐Einstein condensate with interparticle elastic interactions included.
2008
Identification of Plakortide E from the Caribbean Sponge Plakortis halichondroides as a Trypanocidal Protease Inhibitor using Bioactivity-Guided Frac…
2014
In this paper, we report new protease inhibitory activity of plakortide E towards cathepsins and cathepsin-like parasitic proteases. We further report on its anti-parasitic activity against Trypanosoma brucei with an IC50 value of 5 mu M and without cytotoxic effects against J774.1 macrophages at 100 mu M concentration. Plakortide E was isolated from the sponge Plakortis halichondroides using enzyme assay-guided fractionation and identified by NMR spectroscopy and mass spectrometry. Furthermore, enzyme kinetic studies confirmed plakortide E as a non-competitive, slowly-binding, reversible inhibitor of rhodesain.
Dietary exposure in utero and during lactation to a mixture of genistein and an anti-androgen fungicide in a rat mammary carcinogenesis model
2015
Endocrine disruptors may play substantial roles in the high incidence of breast cancer. We previously described how early exposure to the mixture of phytoestrogen genistein (G) and the anti-androgen vinclozolin (V) affects peripubertal mammary development. This study evaluates the carcinogenic potential of exposure to V alone or associated with G from conception until weaning in Wistar rats. Dams were exposed to V, G or GV during pregnancy/lactation. At PND50 offspring were treated with DMBA[7,12-dimethylbenz(a)anthracene]. V or GV maternal exposure decreased number of DMBA-induced mammary tumors in the offspring, without significant modifications in tumor incidence, multiplicity and latenc…
La logica e il mito del linguaggio perfetto
2014
L'articolo sostiene che il sogno di una "linguaggio perfett", inteso come un mezzo di espressione universale e semanticamente trasparente sia strettamente connesso al mito della razionalità istantanea. Il linguaggio logicamente perfetto sarebbe infatti un linguaggio nel quale tutte le relazioni logiche divengono immediatamente visibili, e la questa linguaggio, possa pensare per noi (frege, 1884). nella prima parte dell'articolo si ricostruisce la storia di questo tipo di linguaggio perfetto da Leibniz e Wittgenstein. nella seconda parte si mostra come tale linguaggio non possa esistere sulla base di recenti risultati in logica e computer science. We argue that the dream of a ‘perfect langua…
Excitonic Transitions in Homoepitaxial GaN
2001
The photoluminescence spectrum of a high quality homoepitaxial GaN film has been measured as a function of temperature. As temperature increases the recombination of free excitons dominates the spectra. Their energy shift has successfully fitted in that temperature range by means of the Bose-Einstein expression instead of Varshni's relationship. Values for the parameters of both semi-empirical relations describing the energy shift are reported and compared with the literature.
Bézier Solutions of the Wave Equation
2004
We study polynomial solutions in the Bezier form of the wave equation in dimensions one and two. We explicitly determine which control points of the Bezier solution at two different times fix the solution.
Bose-Einstein Condensation in an electro-pneumatically transformed quadrupole-Ioffe magnetic trap
2014
We report a novel approach for preparing a Bose-Einstein condensate (BEC) of $^{87}$Rb atoms using electro-pneumatically driven transfer of atoms into a Quadrupole-Ioffe magnetic trap (QUIC Trap). More than 5$\times$$10^{8}$ atoms from a Magneto-optical trap are loaded into a spherical quadrupole trap and then these atoms are transferred into an Ioffe trap by moving the Ioffe coil towards the center of the quadrupole coil, thereby, changing the distance between quadrupole trap center and the Ioffe coil. The transfer efficiency is more than 80 \%. This approach is different from a conventional approach of loading the atoms into a QUIC trap wherein the spherical quadrupole trap is transformed…
Born-Infeld gravity and its functional extensions
2014
We investigate the dynamics of a family of functional extensions of the (Eddington-inspired) Born-Infeld gravity theory, constructed with the inverse of the metric and the Ricci tensor. We provide a generic formal solution for the connection and an Einstein-like representation for the metric field equations of this family of theories. For particular cases we consider applications to the early-time cosmology and find that non-singular universes with a cosmic bounce are very generic and robust solutions.
Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma
2018
Recurrent mutations in chromatin modifiers are specifically prevalent in adolescent or adult patients with Sonic hedgehog-associated medulloblastoma (SHH MB). Here, we report that mutations in the acetyltransferase CREBBP have opposing effects during the development of the cerebellum, the primary site of origin of SHH MB. Our data reveal that loss of Crebbp in cerebellar granule neuron progenitors (GNPs) during embryonic development of mice compromises GNP development, in part by downregulation of brain-derived neurotrophic factor (Bdnf). Interestingly, concomitant cerebellar hypoplasia was also observed in patients with Rubinstein-Taybi syndrome, a congenital disorder caused by germline mu…
Spanish Relativity Meeting (ERE 2014): almost 100 years after Einstein's revolution
2015
This volume presents the proceedings of the international scientific conference ''Spanish Relativity Meeting (ERE 2014): almost 100 years after Einstein's revolution''. The conference was devoted to discussing the current state-of-the-art of a wide variety of topics of research in the fields of Gravitation and General Relativity in the ''pre-centennial'' year of General Relativity. The name of the conference was chosen to highlight the importance of the upcoming one hundredth anniversary of Einstein's theory of General Relativity, officially established by the Internal Society on General Relativity and Gravitation in November 25th, 2015. In particular, the conference was organized along thr…