Search results for "Steroid"
showing 10 items of 1005 documents
The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis.
2012
In previous studies, we identified the fungal macrocyclic lactone (S)-curvularin (SC) as an anti-inflammatory agent using a screening system detecting inhibitors of the Janus kinase/signal transducer and activator of transcription pathway. The objective of the present study was to investigate whether SC is able to decrease proinflammatory gene expression in an in vivo model of a chronic inflammatory disease. Therefore, the effects of SC and dexamethasone were compared in the model of collagen-induced arthritis (CIA) in mice. Total genomic microarray analyses were performed to identify SC target genes. In addition, in human C28/I2 chondrocytes and MonoMac6 monocytes, the effect of SC on proi…
Correction to: Echinodermata: The complex immune system in echinoderms (Advances in Comparative Immunology, 10.1007/978-3-319-76768-0_13)
2018
This chapter was inadvertently published with an incorrect spelling of the author's name as V. Arriza whereas it should be V. Arizza. In addition to this the affiliation of one of the chapter authors Elisse Sutton was published incorrectly and it has now been corrected to read as Department of Biological Sciences, Macquarie University, Sydney, NSW, Australia.
Late Cretaceous echinoderm ‘odds and ends’ from the Low Countries
2018
From various levels within the Gulpen and Maastricht formations (upper lower to upper upper Maastrichtian, c. 69.5–66 Ma) in the extended type area of the Maastrichtian Stage (southeast Netherlands, northeast Belgium and the Aachen area in Germany), a few recent additions to echinoderm faunas are illustrated and briefly discussed. Added are some erratic, flint-preserved, pre-Maastrichtian echinoid taxa from Pleistocene fluvial gravel deposits; these are of palaeogeographical interest. Crinoids include the comatulid Semiometra saskiae with traces of sublethal predation and several bourgueticrinines. Amongst the latter, the species Dunnicrinus aequalis is found preserved in biocalcarenites as…
New records of Asteraceae for the non-native flora of Tunisia and north Africa with some nomenclatural remarks
2022
International audience; Sixteen new Asteraceae are added to the non-indigenous flora of Tunisia. Six of them (Dimorphotheca ecklonis, Gaillardia pulchella, Gazania linearis var. linearis, Guizotia abyssinica, Rudbeckia triloba and Tithonia diversifolia) are also new for the flora of North Africa. Chrysanthemum morifolium is here first reported for the Mediterranean Basin. Seven genera (Argyranthemum, Bidens, Dimorphotheca, Gaillardia, Guizotia, Rudbeckia and Tithonia) are recorded for the first time for the vascular flora of Tunisia. Most of these species escaped from gardens and pots and became casual along roadsides and/or disturbed areas after cypsela dispersion (except for Chrysanthemum…
Ruolo ecologico degli Asteroidei in due comunità dell'infralitorale superiore dell'Isola di Ustica
2009
Gli asteroidi sono predatori che si ritrovano comunemente negli ecosistemi marini di fondo duro e mobile. Nell’Area Marina Protetta “Isola di Ustica” il divieto di raccolta del riccio edule Paracentrotus lividus nell’infralitorale superiore, ha determinato la sostituzione della comunità ad alghe fotofile erette con una comunità dominata da alghe incrostanti e ricci (barren) in gran parte dell’isola. Tre specie di asteroidi, Marthasterias glacialis, Ophidiaster ophidianus e Coscinasterias tenuispina, si ritrovano comunemente sia nell’habitat dominato dal barren che in quello dove rimangono elevate coperture ad alghe fotofile erette. Sono state studiate la distribuzione e le abitudini aliment…
Philae's first days on the comet
2015
On 12 November 2014, Philae landed on the surface of comet 67P/Churyumov-Gerasimenko (67P), making an almost 30-year dream a reality. The pioneering flybys of 1P/Halley in 1986 revealed that despite being made primarily of ice, it was covered in highly absorbing carbonrich molecules. What is their composition? When did they form, and through which chemical routes? Might they have constituted prebiotic molecules necessary for life? At a larger scale, what can one learn from comets that has relevance to the evolution of the solar system and planets? ![Figure][1] 12 NOVEMBER 2014: PHILAE LANDED ON THE NUCLEUS OF COMET 67P CREDIT: ESA/ROSETTA/MPS FOR OSIRIS TEAM MPS/UPD/LAM/IAA/SSO/INTA/UPM/DAS…
Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothal…
2015
Endocannabinoids participate in the control of neurogenesis, neural cell death and gliosis. The pharmacological effect of the fatty acid amide hydrolase (FAAH) inhibitor URB597, which limits the endocannabinoid degradation, was investigated in the present study. Cell proliferation (phospho-H3(+) or BrdU(+) cells) of the main adult neurogenic zones as well as apoptosis (cleaved caspase-3(+)), astroglia (GFAP(+)), and microglia (Iba1(+) cells) were analyzed in the hippocampus, hypothalamus and striatum of rats intraperitoneally treated with URB597 (0.3 mg/kg/day) at one dose/4-days resting or 5 doses (1 dose/day). Repeated URB597 treatment increased the plasma levels of the N-acylethanolamine…
Sexual dimorphism in immune function: The role of sex steroid hormones
2018
There is evidence of the relation of sex steroid hormones and sexual dimorphism in immune system response to infectious diseases. The aim of this review was to identify the role of sex hormones in immune function and sexual dimorphism of immune reactions. Gonadal hormones together with the immune system play an important role in process of immune responses to the disease [1]. Estrogens, progesterone and testosterone have different impacts on immune cells and different gonadal hormones are of high importance for responses of innate and adaptive immunity [1, 2]. Estrogens mainly enhance immune function while testosterone has a suppressive role. Higher progesterone during pregnancy leads to au…
Efficacy of the antioxidant ebselen in experimental uveitis.
1999
Inflammation results in the production of free radicals. In a model of experimental uveitis upon subcutaneous injection of endotoxin to Lewis rats, i.e., endotoxin-induced experimental uveitis (EIU), we have evaluated the status of the antioxidant capacity of ocular tissues. EIU results in a decrease of glutathione (GSH) content and glutathione peroxidase (GPx) activity in whole eye homogenates 24-h after endotoxin administration. Furthermore, an increase in malondialdehyde (MDA) content was observed in these same samples, thus confirming the involvement of oxidative stress in the pathophysiology of the process. In view of the ability of the antioxidant ebselen as GPx enzyme mimic, we teste…
Effects in cigarette smoke stimulated bronchial epithelial cells of a corticosteroid entrapped into nanostructured lipid carriers
2014
Background Nanomedicine studies have showed a great potential for drug delivery into the lung. In this manuscript nanostructured lipid carriers (NLC) containing Fluticasone propionate (FP) were prepared and their biocompatibility and effects in a human bronchial epithelial cell line (16-HBE) stimulated with cigarette smoke extracts (CSE) were tested. Results Biocompatibility studies showed that the NLC did not induce cell necrosis or apoptosis. Moreover, it was confirmed that CSE increased intracellular ROS production and TLR4 expression in bronchial epithelial cells and that FP-loaded NLC were more effective than free drug in modulating these processes. Finally, the nanoparticles increased…