Search results for "Stimuli"
showing 10 items of 123 documents
Behavioral and physiological bases of relaxing and stimulating effects of odors and music
2021
This doctoral thesis examines the psychological and physiological mechanisms as well as the factors involved in the relaxing and stimulating effect (emotional activation) of pleasant odors, building on research work from the music domain. In Studies 1a and 1b, we observed that the modulation of the activation induced by odors influenced temporal information processing by speeding-up or slowing-down the rate of the internal clock pacemaker, similarly to what was previously reported using musicalstimuli. Moreover, prior verbalsuggestion attributing incongruent activation properties to the odors eliminated these effects, highlighting the importance of a priori expectancies on olfactory-induced…
Microfluidic Synthesis of Actuating Microparticles from a Thiol-Ene Based Main-Chain Liquid Crystalline Elastomer.
2016
In this article the microfluidic synthesis of strongly actuating particles on the basis of a liquid crystalline main-chain elastomer is presented. The synthesis is carried out in a capillary-based co-flow microreactor by photo-initiated thiol-ene click chemistry of a liquid crystalline monomer mixture. These microparticles exhibit a deformation from a spherical to a rod-like shape during the thermal-initiated phase transition of the liquid crystalline elastomer (LCE) at which the particles’ aspect ratio is almost doubled. Repeated contraction cycles confirm the complete reversibility of the particles’ actuation properties. The transition temperature of the LCE, the temperature range of the …
Subliminal fear priming potentiates negative facial reactions to food pictures in women with anorexia nervosa.
2010
BackgroundTo investigate hedonic reactivity and the influence of unconscious emotional processes on the low sensitivity to positive reinforcement of food in anorexia nervosa (AN).MethodAN and healthy women were exposed to palatable food pictures just after a subliminal exposure to facial expressions (happy, disgust, fear and neutral faces), either while fasting or after a standardized meal (hungerversussatiety). Both implicit [facial electromyographic (EMG) activity from zygomatic and corrugator muscles, skin conductance, heart rate, and videotaped facial behavior] and explicit (self-reported pleasure and desire) measures of affective processes were recorded.ResultsIn contrast to healthy wo…
Prospective Cancer Therapies Using Stimuli‐Responsive DNA Nanostructures
2021
Financial support by the Emil Aaltonen Foundation, the Sigrid Jusélius Foundation, the Magnus Ehrnrooth Foundation, Academy of Finland (grants no. 317042 and 331151), the Jane and Aatos Erkko Foundation and the Vilho, Yrjö and Kalle Väisälä Foundation of the Finnish Academy of Science and Letters is gratefully acknowledged Nanostructures based on DNA self-assembly present an innovative way to address the increasing need for target-specific delivery of therapeutic molecules. Currently, most of the chemotherapeutics being used in clinical practice have undesired and exceedingly high off-target toxicity. This is a challenge in particular for small molecules, and hence, developing robust and ef…
Synthesis and characterization of redox-sensitive polyurethanes based on L-glutathione oxidized and poly(ether ester) triblock copolymers
2021
Abstract Segmented polyurethanes, based on PCL-PEG-PCL copolymers, 1,4-diisocyanatobutane and l -glutathione oxidized, used as chain extender, were synthetized. Three different reactions conditions were investigated using three different copolymers having ɛ-CL/polyethylene glycol molar ratios equal to 12, 24 and 36 and three different reaction conditions. As investigated by size exclusion chromatography analyses and quantification of l -glutathione, the polymerization and the extension phase's efficiency depended on the ɛ-CL/PEG ratio and the extension phase's operating temperature. Three selected polyurethanes were characterized by spectroscopic, differential scanning calorimetry (DSC) and…
Nordic Comparison of 75-Year-Olds - Sensory and Psychomotor Functions
1993
Sensory and psychomotor functions were studied among 75-year-old men and women in three Nordic localities (Glostrup in Denmark, Gothenburg in Sweden, and Jyvaskyla in Finland) as part of a comparative study on functional capacity and health. Random samples were drawn from the population registers in Glostrup (n=550) and Gothenburg (n=450), whereas in Jyvaskyla all 75-year-old residents (n=388) were invited to participate in the study. Participation rates varied from 66.8% in Gothenburg to 79.1% in Jyvaskyla. Sensory functions studied included hearing (pure-tone thresholds at 125-8000 Hz), vision (visual acuity, refraction, intraocular pressure), balance (postural sway), and tactual sensitiv…
Attitudes toward everyday odors for children with visual impairments: A pilot study
2010
The question of how the processing of stimuli from the external world is organized or reorganized when a sensory modality is altered or missing has been the subject of numerous studies, although the studies have mostly been on tactile and auditory abilities (Hatwell, 2003). In contrast, olfaction has been poorly investigated in people who are visually impaired, despite the increasing evidence that humans have a keen sense of smell (Schaal & Porter, 1991). Odors influence mood; well-being (Ehrlichman & Bastone, 1992); and social interactions, such as the choice of partners (Herz & Inzlicht, 2002). Emotional and social implications of odors go back to the earliest periods of development (Scha…
Subcomponent Self-Assembly A Quick Way to New Metallogels
2013
Subcomponent self-assembly, introduced by the Nitschke group,[1] is a process which allow complex structures to be generated from simple building blocks (generally aldehydes and amines). In this bottom-up approach, the building blocks spontaneously self-assemble around templates (usually metal ions) leading to a simultaneous covalent (C=N) and dative (N– metal) bonds formation. The method has been successfully used to construct well-defined metal-organic macrocycles, helicates, catenanes, rotaxanes, grids,[2] and cages.[3] Our field of interest lies not in building-up of defined structures but in designing gelator molecules for a formation of supramolecular gels as functional nanomaterials.…
Development of stimulus-sensitive electrospun membranes based on novel biodegradable segmented polyurethane as triggered delivery system for doxorubi…
2022
In this work, redox-sensitive polyurethane urea (PUU) based electrospun membranes have been exploited to chemically tether a pH-sensitive doxorubicin derivative achieved by linking a lipoyl hydrazide to the drug via a hydrazone linkage. First, the lipoyl-hydrazone-doxorubicin derivative labelled as LA-Hy-Doxo has been syn- thesized and characterized. Then, the molecule has been tethered, via a thiol-disulfide exchange reaction, to the redox-sensitive PUU (PolyCEGS) electrospun membrane. The redox-sensitive PolyCEGS PUU has been produced by using PCL-PEG-PCL polyol and glutathione-tetramethyl ester (GSSG-OMe)4 as a chain extender. The LA-Hy- Doxo tethered electrospun membrane has showed a du…