Search results for "Stone"
showing 10 items of 1137 documents
Anti-senescence and Anti-inflammatory Effects of the C-terminal Moiety of PTHrP Peptides in OA Osteoblasts.
2016
Osteoarthritis (OA) is characterized by degenerative changes in the whole joint leading to physical disability in the elderly population. This condition is associated with altered bone metabolism in subchondral areas suggesting that therapeutic strategies aimed at modifying bone cell metabolism may be of interest. We have investigated the effects of several parathyroid hormone-related protein (PTHrP)-derived peptides (1-37): (N-terminal), (107-111) and (107-139) (C-terminal) on senescence features induced by inflammatory stress in human OA osteoblasts. Incubation of these primary cells with interleukin(IL)-1β led to an increased expression of senescence markers senescence-associated-β-galac…
Treatment with a CO-releasing molecule (CORM-3) reduces joint inflammation and erosion in murine collagen-induced arthritis.
2008
Contains fulltext : 70589.pdf (Publisher’s version ) (Closed access) OBJECTIVE: CO-releasing molecules (CO-RMs) are a novel class of anti-inflammatory agents. We have examined the possible therapeutic effects of CORM-3 in collagen-induced arthritis (CIA). METHODS: Arthritis was induced in DBA-1/J mice by type II collagen. Animals were treated with CORM-3 (5 and 10 mg/kg/day, intraperitoneally) or the inactive compound iCORM-3 (10 mg/kg/day, intraperitoneally) unable to release CO, from days 22 to 31. Production of anti-type II collagen antibodies, cytokines and cartilage olimeric matrix protein (COMP) was evaluated by enzyme-linked immunosorbent assay, and prostaglandin E(2) (PGE(2)) by rad…
Experimental Procedures of Accelerated Aging and Evaluation of Effectiveness of Nanostructured Products for the Protection of Volterra (Italy) Panchi…
2022
The aims of the research were to evaluate the effectiveness of the application of nanostructured products on Volterra calcarenite stone and to define the experimental conditions and procedures of accelerated aging tests, able to simulate different degradation on the studied lithotype. The work focused on methods of performing accelerated aging tests in order to simulate different effects of environmental decay involving stone used on a historical site. The rock samples were examined before and after three treatment types: cyclic salt spray chamber, cycles of freezing–thawing and cycles of thermal shock. After each artificial aging cycle, changes in appearance were noted and chemical and phy…
La pierre et les hommes en Bourgogne. Archéologie et histoire d'une ressource en œuvre du Moyen Âge à l'Époque Moderne
2014
In order to go further limits inherent to subject disjunction, or those imposed by sources, periods or sites, this thesis emphasises a multidisciplinary and diachronic approach of stone supply on medieval and modern building sites. Thanks to the confrontation of buildings with different origins and functions, this work tries to dissect process of choices and stone supply network. It finally considers connection between people and a natural ressource.
Le Clos de Vougeot (Côte-d’Or) : nouvelles observations sur les matériaux de construction et la chronologie du bâti médiéval
2009
Mithilfe sehr unterschiedlicherMethoden hat es sich diese Arbeit vor allem zur Aufgabe gemacht, bestimmte Phasen der Baugeschichte des Clos de Vougeot zu verstehen, um die Organisation und die Entwicklungen eines Zisterzienserhofsin Hinsicht auf diesozialen und historischen Wandlungen besser zu verstehen. Diese Studie bot ebenfalls Gelegenheit, die geologischen Eigenschaften der im Clos de Vougeot eingebrachten Baumaterialien genauestens zu untersuchen und neue Erkenntnisse zum Bau dieser Gebäude zu gewinnen und zu präzisieren.
Decay assessment of stone-built cultural heritage: The case study of the cosenza cathedral façade (south calabria, italy)
2021
This study aims to assess the different decay phenomena affecting the Cosenza Cathedral façade (Calabria, South Italy) through the evaluation of the relative damage indices. For this goal, a multidisciplinary approach was applied exploiting both nondestructive and microdestructive techniques. Such a combination enabled proposing an intervention priority scale that can be helpful to institutions when planning a prompt restoration intervention. The results suggest the efficiency of this approach to obtain a multidisciplinary diagnostic and conservation system for the management and valorization of the Cultural Heritage also in terms of monitoring, maintenance, and selection of the most suitab…
Comparison between NMR and MIP in characterizing porosity of limestone used in Cultural Heritage,
2015
Limestone with different porosity are used extensively as a sculptural and architectural stone in artistic-architectural field. As it is known, this kind of material is subjected to physico-chemical decay that involves the loss of surface and in-depth cohesion [1]. Consolidation interventions are performed in order to preserve building and decorative surfaces of architectural monuments, to reduce their degradation rate and to improve cohesion and adhesion in the stone [2]. Porosity of stone and pore size distribution are important factors to evaluate the effectiveness of a consolidation treatment and they are normally performed using a single technique such as mercury intrusion porosimetry,…
Biodiverse green roofs in Mediterranean climate. Input and lessons learned from Germany and Switzerland
In the realm of the doctoral program in technologies for sustainability and land restoration, this thesis deepens sustainable and ecological solutions for Mediterranean environment after the German tradition and the Swiss school of green roofs for biodiversity. Specific aims were to: (1) assess the effectiveness of the existing green roofs norms in supporting biodiversity; (2) review methodologies and approaches for the implementation of biodiverse green roofs but also their application for ecological design; (3) identify habitat templates in the Mediterranean ecoregion replicable on green roofs; and (4) investigate the long term vegetation development of unmanaged green roofs in order to g…
Comprehensive analysis of interacting proteins and genome-wide location studies of the Sas3-dependent NuA3 histone acetyltransferase complex
2014
Highlights • We characterise Sas3p and Gcn5p active HAT complexes in WT and deleted TAP-strains. • We confirm that Pdp3p interacts with NuA3, histones and chromatin regulators. • Pdp3p MS-analysis reveals its phosphorylation, ubiquitination and methylation. • Sas3p can substitute Gcn5p in acetylation of histone H3K14 but not of H3K9. • Genome-wide profiling of Sas3p supports its involvement in transcriptional elongation.
Letter to the editor:Triclosan in patients with inflammatory bowel disease
2022
Letter to the editor