Search results for "Subtype"

showing 10 items of 117 documents

Changes in quality of life in individuals with narcolepsy type 1 after the H1N1-influenza epidemic and vaccination campaign in Norway: a two-year pro…

2018

Abstract Objective Cross-sectional studies show a lower health-related quality of life (HRQoL) in individuals with narcolepsy. We aimed to describe changes in HRQoL after two years of multidisciplinary follow-up in a cohort of mainly post-H1N1 vaccination narcolepsy type-1 (NT1) patients in Norway. Methods Prospective-cohort study. Narcolepsy diagnosis was based on the International Classification of Sleep Disorders (third edition). Psychiatric comorbidity was assessed using the Achenbach System of Empirically Based Assessment (ASEBA). HRQoL was evaluated with the Pediatric Quality of Life Inventory (PedsQL™ Generic Core Scales 4.0) at baseline and follow-up. Mean follow-up time was 20.7 (2…

MalePediatricsmedicine.medical_specialtyAdolescentComorbiditySeverity of Illness IndexYoung Adult03 medical and health sciencesInfluenza A Virus H1N1 Subtype0302 clinical medicineQuality of lifeInfluenza HumanmedicineHumansInternational Classification of Sleep DisordersProspective Studies030212 general & internal medicineChildProspective cohort studyNarcolepsyImmunization ProgramsNorwaybusiness.industryVaccinationGeneral Medicinemedicine.diseasehumanitiesPeer reviewVaccinationCross-Sectional StudiesTest scoreCohortQuality of LifeFemaleSodium Oxybatebusiness030217 neurology & neurosurgeryAdjuvants AnesthesiaNarcolepsySleep Medicine
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Endothelial function and arterial stiffness indexes in subjects with acute ischemic stroke: Relationship with TOAST subtype.

2017

Abstract Background and aims Only one study has examined endothelial function in subjects with acute ischemic stroke and no study has yet assessed arterial stiffness and reactive hyperemia peripheral arterial tonometry (RH-PAT) in ischemic stroke and its clinical subtypes. Our study aimed to evaluate arterial stiffness and endothelial dysfunction indexes in patients with acute ischemic stroke and the relationship between endothelial dysfunction indexes and arterial stiffness markers and stroke subtypes according to Trial of Org 10172 in Acute Stroke Treatment (TOAST) Classification. Methods We enrolled 98 patients with a diagnosis of acute ischemic stroke and 105 hospitalized patients witho…

MaleSettore MED/09 - Medicina InternaSubtype030204 cardiovascular system & hematologyBrain Ischemia0302 clinical medicineRisk FactorsIschemicOdds RatioMedicineEndothelial dysfunctionEndothelial dysfunctionAcute ischemic strokePulse wave velocityStrokeEndothelial dysfunction; Ischemic; Stiffness; Stroke; Subtypes; TOASTAged 80 and overMiddle AgedTOASTPeripheralStrokeCardiologyFemaleCardiology and Cardiovascular Medicinemedicine.medical_specialtyManometryHyperemiaPulse Wave Analysis03 medical and health sciencesVascular StiffnessPredictive Value of Testsmedicine.arteryInternal medicineHumanscardiovascular diseasesRadial arteryReactive hyperemiaAgedChi-Square Distributionbusiness.industrymedicine.diseaseSurgerybody regionsLogistic ModelsCase-Control StudiesMultivariate AnalysisArterial stiffnessStiffneEndothelium Vascularbusiness030217 neurology & neurosurgery
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Mediterranean Diet in patients with acute ischemic stroke: Relationships between Mediterranean Diet score, diagnostic subtype, and stroke severity in…

2015

Abstract Background Adherence to a Mediterranean Diet appears to reduce the risk of cardiovascular disease, cancer, Alzheimer's disease, and Parkinson's disease, as well as the risk of death due to cardiovascular disease. No study has addressed the association between diagnostic subtype of stroke and its severity and adherence to a Mediterranean Diet in subjects with acute ischemic stroke. Aim To evaluate the association between Mediterranean Diet adherence, TOAST subtype, and stroke severity by means of a retrospective study. Methods The type of acute ischemic stroke was classified according to the TOAST criteria. All patients admitted to our ward with acute ischemic stroke completed a 137…

MaleTOAST subtypemedicine.medical_specialtySettore MED/09 - Medicina InternaMediterranean dietPopulationDiseaseDiet MediterraneanSeverity of Illness IndexBrain IschemiaBrain ischemiaMediterranean Diet scoreRisk FactorsSurveys and QuestionnairesInternal medicineSeverity of illnessmedicineHumanscardiovascular diseaseseducationStrokeAgedRetrospective Studieseducation.field_of_studyMediterranean Dietbusiness.industryRetrospective cohort studyMiddle Agedmedicine.diseaseStrokeSSS*Cardiovascular DiseasesPhysical therapyPatient ComplianceRegression AnalysisFemaleCardiology and Cardiovascular MedicinebusinessAtherosclerosis
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2011–12 Seasonal Influenza Vaccines Effectiveness against Confirmed A(H3N2) Influenza Hospitalisation: Pooled Analysis from a European Network of Hos…

2013

BackgroundInfluenza vaccination strategies aim at protecting high-risk population from severe outcomes. Estimating the effectiveness of seasonal vaccines against influenza related hospitalisation is important to guide these strategies. Large sample size is needed to have precise estimate of influenza vaccine effectiveness (IVE) against severe outcomes. We assessed the feasibility of measuring seasonal IVE against hospitalisation with laboratory confirmed influenza through a network of 21 hospitals in the European Union.MethodsWe conducted a multicentre study in France (seven hospitals), Italy (one hospital), and Navarra (four hospitals) and Valencia (nine hospitals) regions in Spain. All ≥1…

MaleViral DiseasesEpidemiologyPilot ProjectsLogistic regressionmedicine.disease_cause0302 clinical medicineInfluenza A virusClinical Epidemiology030212 general & internal medicineEpidemiological Methodsmedia_commonAged 80 and overeducation.field_of_studyVaccinesMultidisciplinaryQVaccinationREpidemiology of AgingMiddle Aged3. Good healthVaccinationHospitalizationInfectious DiseasesInfluenza VaccinesMedicineFemaleSeasonsResearch ArticleAdultmedicine.medical_specialtyAdolescentInfluenza vaccineClinical Research DesignScience030231 tropical medicinePopulationMicrobiologyHistory 21st CenturyInfectious Disease Epidemiology03 medical and health sciencesYoung AdultInternal medicineVirologyVaccine DevelopmentInfluenza Humanmedicinemedia_common.cataloged_instanceHumansEuropean UnionEuropean unioneducationBiologyAgedbusiness.industryInfluenza A Virus H3N2 SubtypeCase-control studyImmunityViral VaccinesInfluenzaSample size determinationCase-Control StudiesImmunologyClinical ImmunologybusinessPLoS ONE
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Sociodemographic Factors and Clinical Conditions Associated to Hospitalization in Influenza A (H1N1) 2009 Virus Infected Patients in Spain, 2009–2010

2012

The emergence and pandemic spread of a new strain of influenza A (H1N1) virus in 2009 resulted in a serious alarm in clinical and public health services all over the world. One distinguishing feature of this new influenza pandemic was the different profile of hospitalized patients compared to those from traditional seasonal influenza infections. Our goal was to analyze sociodemographic and clinical factors associated to hospitalization following infection by influenza A(H1N1) virus. We report the results of a Spanish nationwide study with laboratory confirmed infection by the new pandemic virus in a case-control design based on hospitalized patients. The main risk factors for hospitalizatio…

MaleViral DiseasesPediatricsNon-Clinical MedicinePulmonologyEpidemiology:Named Groups::Persons::Age Groups::Adult::Aged::Aged 80 and over [Medical Subject Headings]Grip A (H1N1):Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]DiseaseSocial and Behavioral Sciencesmedicine.disease_cause:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings]Hospital patients:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Influenza A Virus H1N1 SubtypeGripe humanaSociologyRisk FactorsPandemicInfluenza A virusChildAged 80 and over:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]:Organisms::Viruses::Vertebrate Viruses::RNA Viruses::Orthomyxoviridae::Influenzavirus A::Influenza A virus::Influenza A Virus H1N1 Subtype [Medical Subject Headings]COPDeducation.field_of_studyMultidisciplinary:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings]:Named Groups::Persons::Age Groups::Child::Child Preschool [Medical Subject Headings]QRMiddle AgedHospitalizationInfectious Diseases:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization [Medical Subject Headings]Child Preschool:Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings]MedicineFemalePublic Health:Named Groups::Persons::Age Groups::Infant [Medical Subject Headings]Assistència hospitalàriaResearch ArticleAdultmedicine.medical_specialtyAdolescent:Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings]SciencePopulationHospitals -- Pacients:Check Tags::Male [Medical Subject Headings]:Named Groups::Persons::Age Groups::Infant::Infant Newborn [Medical Subject Headings]InfluenzavirusVirusYoung AdultInfluenza HumanSubtipo H1N1 del Virus de la Influenza A:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]medicineInfluenza virusesHumansEpidemiologia -- Investigació -- EspanyaEspanyaEpidemiologiaeducationPandemicsBiology:Named Groups::Persons::Age Groups::Child [Medical Subject Headings]AgedHospital carePopulation Biologybusiness.industryPublic healthInfant NewbornCase-control studyInfant:Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemics [Medical Subject Headings]medicine.disease:Check Tags::Female [Medical Subject Headings]SpainCase-Control StudiesH1N1 influenza:Diseases::Virus Diseases::RNA Virus Infections::Orthomyxoviridae Infections::Influenza Human [Medical Subject Headings]businessPLoS ONE
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The Factors Affecting Expansion of Reactive Tumor Infiltrating Lymphocytes (TIL) From Bladder Cancer and Potential Therapeutic Applications

2021

Tumor infiltrating lymphocytes (TIL) therapy was shown to provide durable objective response in patients with metastatic melanoma. As a fundamental first step to bring TIL therapy to clinical use, identification of patients whose tumors yield optimal numbers of reactive TIL is indispensable. We have previously shown that expansion of tumor reactive TIL from primary bladder tumors and lymph node metastases is feasible. Here, we performed TIL harvesting from additional surgical specimens (additional 31 primary tumors and 10 lymph nodes) to generate a heterogenous cohort of 53 patients with bladder cancer (BC) to evaluate the tumor characteristics that lead to tumor-reactive TIL expansion. Amo…

Malelcsh:Immunologic diseases. AllergyCD3Immunologychemical and pharmacologic phenomenaBacillus Calmette–GuerinLymphocyte ActivationCancer VaccinesImmunotherapy AdoptiveCohort StudiesBasal (phylogenetics)Tumor Necrosis Factor Receptor Superfamily Member 9Lymphocytes Tumor-InfiltratingmedicineImmunology and AllergyHumansadoptive cellular immunotherapyLymph nodeCells CulturedAgedCell ProliferationOriginal Researchmolecular subtypesBladder cancerbiologyTumor-infiltrating lymphocytesbusiness.industryhemic and immune systemsMiddle Agedmedicine.diseaseMycobacterium bovismedicine.anatomical_structureUrinary Bladder NeoplasmsLymphatic Metastasistumor-infiltrating lymphocytesCancer researchbiology.proteinInterleukin-2bladder cancerFemaleLymphAntibodyUrotheliumbusinesslcsh:RC581-607CD8Frontiers in Immunology
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Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors

2012

The H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis.A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used.The mean age was 38.5 years (SD 22.…

Malemedicine.disease_causeInfluenza A Virus H1N1 SubtypepreventionPregnancyInfluenza A virusPharmacology (medical)Young adultChildOriginal ResearchAged 80 and overNeuraminidase inhibitorbiologyMiddle AgedPrognosisHospitalizationInfectious DiseasesChild PreschoolFemaleMicrobiology (medical)Adultmedicine.medical_specialtyAdolescentCritical Caremedicine.drug_classNeuraminidaseadverse outcomesAntiviral AgentsYoung Adultlength of stayInternal medicineDiabetes mellitusIntensive careInfluenza HumanmedicineHumansSurvival analysisAgedPharmacologyPregnancyflubusiness.industrypandemicInfant NewbornInfantLength of Staymedicine.diseaseSurvival AnalysisSpainImmunologybiology.proteinbusinessNeuraminidase
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Muscarinic inhibition of endogenous noradrenaline release from rabbit isolated trachea: receptor subtype and receptor reserve.

1994

The aim of the present study was to characterize putative muscarine receptors on sympathetic nerve terminals in the rabbit trachea. Release of endogenous noradrenaline from in vitro incubated rabbit trachea was evoked by electrical field stimulation (3 Hz, 540 pulses) and quantified by high performance liquid chromatography with electrochemical detection. The muscarine receptor agonist oxotremorine inhibited the evoked release of noradrenaline completely at 1 mumol/l (EC50: 64 nmol/l). The concentration response curve was very steep (Hill coefficient of 2.3). Scopolamine shifted the concentration response curve of oxotremorine to the right (-log KB 8.48) demonstrating specific, inhibitory m…

Malemedicine.medical_specialtyIndomethacinCholinergic AgentsEndogenyMuscarinic AntagonistsIn Vitro TechniquesMuscarinic AgonistsHigh-performance liquid chromatographyReceptor subtypechemistry.chemical_compoundNorepinephrineAdrenergic AgentsInternal medicineMuscarinic acetylcholine receptormedicineAnimalsReceptorPharmacologyMuscarineBinding SitesPhenoxybenzamineChemistryRabbit (nuclear engineering)General Medicinerespiratory systemReceptors MuscarinicIn vitroElectric StimulationTracheaEndocrinologyFemaleRabbitsNaunyn-Schmiedeberg's archives of pharmacology
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Incidence of hematologic malignancies in Europe by morphologic subtype: Results of the HAEMACARE project

2010

AbstractChanging definitions and classifications of hematologic malignancies (HMs) complicate incidence comparisons. HAEMACARE classified HMs into groupings consistent with the latest World Health Organization classification and useful for epidemiologic and public health purposes. We present crude, age-specific and age-standardized incidence rates for European HMs according to these groupings, estimated from 66 371 lymphoid malignancies (LMs) and 21 796 myeloid malignancies (MMs) registered in 2000-2002 by 44 European cancer registries, grouped into 5 regions. Age-standardized incidence rates were 24.5 (per 100 000) for LMs and 7.55 for MMs. The commonest LMs were plasma cell neoplasms (4.6…

Malemedicine.medical_specialtyPathologyChildhood leukemiaHematologic malignant; Europe; morphologic subtype; international comparison; population-based cancer registry.ImmunologyPopulationUNITED-STATESALCOHOLBiochemistryNOMyelodysplastic–myeloproliferative diseasesInternal medicineEpidemiologymorphologymedicineLYMPHOMAHumansEPIDEMIOLOGYRegistriesEXPOSUREeducationRISKeducation.field_of_studyTOBACCOhaematologic malignanciesbusiness.industryIncidence (epidemiology)IncidenceleukemiaMyeloid leukemiaCell BiologyHematologyHematologic malignancies; morphology; Europe.Plasma cell neoplasmmedicine.diseaseMyelodysplastic-Myeloproliferative DiseasesLymphomaEuropeCANCER INCIDENCEHematologic Neoplasmscancer incidence tobacco alcohol epidemiology leukemia risk exposureCHILDHOOD LEUKEMIAHematologic malignanciesFemalebusiness
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Plasma levels of inflammatory and thrombotic/fibrinolytic markers in acute ischemic strokes: Relationship with TOAST subtype, outcome and infarct site

2009

BACKGROUND: The aim of our study was to evaluate in patients with acute ischemic stroke the relationship between immuno-inflammatory variables, clinical outcome and infarct site. MATERIALS AND METHODS: We evaluated plasma levels of IL-1beta, TNF-alpha, IL-6 and IL-10, E-selectin, P-selectin, sICAM-1 ,sVCAM-1 vWF, TPA and PAI-1. RESULTS: Patients with cardioembolic subtype showed significantly higher median plasma levels of TNF-alpha, IL-6, IL-1beta whereas the lacunar subtype showed significantly lower median plasma levels of TNF-alpha, IL-6 and IL-1beta. CONCLUSIONS: A significant association was noted between the severity of neurological deficit at admission, the diagnostic subtype and so…

Malemedicine.medical_specialtystroke TOAST subtypeImmunologyInflammationGastroenterologyBrain IschemiaInternal medicinemedicineHumansImmunology and AllergyIn patientAcute ischemic strokeStrokeAgedNeurological deficitAged 80 and overbusiness.industryFibrinolysisIschemic strokesCerebral InfarctionPlasma levelsMiddle Agedmedicine.diseaseStrokeNeurologyPhysical therapyFemaleNeurology (clinical)Inflammation MediatorsIntracranial Thrombosismedicine.symptombusinessBiomarkersJournal of Neuroimmunology
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