6533b7d0fe1ef96bd125b044

RESEARCH PRODUCT

Plasma levels of inflammatory and thrombotic/fibrinolytic markers in acute ischemic strokes: Relationship with TOAST subtype, outcome and infarct site

Giuseppe LicataAntonia SerioAntonino TuttolomondoRiccardo Di SciaccaDomenico Di RaimondoGisella D'aguannoSerena MonacoEraldo NatalèSergio La PlacaValentina ArnaoLuciana MarinoRosaria PecoraroAntonio Pinto

subject

Malemedicine.medical_specialtystroke TOAST subtypeImmunologyInflammationGastroenterologyBrain IschemiaInternal medicinemedicineHumansImmunology and AllergyIn patientAcute ischemic strokeStrokeAgedNeurological deficitAged 80 and overbusiness.industryFibrinolysisIschemic strokesCerebral InfarctionPlasma levelsMiddle Agedmedicine.diseaseStrokeNeurologyPhysical therapyFemaleNeurology (clinical)Inflammation MediatorsIntracranial Thrombosismedicine.symptombusinessBiomarkers

description

BACKGROUND: The aim of our study was to evaluate in patients with acute ischemic stroke the relationship between immuno-inflammatory variables, clinical outcome and infarct site. MATERIALS AND METHODS: We evaluated plasma levels of IL-1beta, TNF-alpha, IL-6 and IL-10, E-selectin, P-selectin, sICAM-1 ,sVCAM-1 vWF, TPA and PAI-1. RESULTS: Patients with cardioembolic subtype showed significantly higher median plasma levels of TNF-alpha, IL-6, IL-1beta whereas the lacunar subtype showed significantly lower median plasma levels of TNF-alpha, IL-6 and IL-1beta. CONCLUSIONS: A significant association was noted between the severity of neurological deficit at admission, the diagnostic subtype and some inflammatory variables.

yearjournalcountryeditionlanguage
2009-01-28Journal of Neuroimmunology
https://doi.org/10.1016/j.jneuroim.2009.06.019